HCG - 12 Week Case Study

Ok, so we all know that HCG’s main purpose in the world of TRT is to sustain fertility, and help prevent testicular atrophy in those who are either so in love with their balls that they actually think their girl will notice if they shrink by a 1/16 of an inch, OR those rare few who experience real pain with atrophy. No judgement here, and it’s not up to me to decide how important either one of those reasons are to you or anyone else.

The thing that has been not been given much attention, and is really only theoretical and not proven in any study that I know of, is the idea that elevated LH can be beneficial for optimal adrenal function. This is what I’m interested in.

It’s also been very well documented that there are some men who feel like crap on HCG, and some who swear by how much better they feel while taking HCG. To whit, I would like to find if there is a reason for the somewhat evenly divided split. My very ill-educated hypothesis on the subject is this…

I theorize (key word being theorize) that there is one of two main reasons that could be responsible for those guys who do not tolerate HCG well.

  1. They don’t stay on it long enough to allow levels to equalize.
  2. These guys are secondary hypogonadism

Number one is self explanatory and the length of this experiment should negate that possibility. I’ll try to explain my basis for number two. I think that for the secondary guys, whose testicles function quite well but their pituitary cannot produce enough LH and FSH to take advantage of that function, boosting their levels of LH with HCG may give their natural testosterone production enough of a kick as to add a significant amount to the exogenous testosterone being injected, and throw the hormone levels into somewhat of a frenzy. I think it would be worth polling the different camps on HCG and compare their testosterone deficiency prognosis. This would be a very hard poll to take as most do not really go the extra mile to determine the cause before they start injecting and shut down LH and FSH production.

I also think that, in the theoretical case mentioned above, that some or even most of these guys may be overweight and therefore, not only do they kickstart the production of testosterone, but also cause the well functioning testicles to produce endogenous estradiol. Having a higher than normal aromatase rate due to being overweight could add significantly to those estradiol levels, especially since the testorone levels are now higher as well, making more available for aromatase. I think these two factors could be a viable possibility as to why some guys feel badly when the natural feedback loop of hormone production is started back up.

Now, that all being said, I myself know that I am primary hypogonadism, so I don’t expect much in the way of significant natural production adding to my TRT protocol. If I can successfully implement HCG into my protocol I know that it will not PROVE anything, but it will be a step in a good direction I think. I’m at the very least giving some experience based credence to my theory. Maybe not.

Ok so here is the experiment…

I got the HCG in today (12000IU total) and will inject 500IU on Monday’s and Thursday’s for a total of 1000IU per week for the next 12 weeks. I have been on Test Cyp only (no AI) for around 8 months and am fairly stable and feel pretty good. My current protocol is 50mg Test MWF (150mg per week Total).

I will post my last labs (taken about 2 months ago) a little later on. My next labs are due at about the same time this 12 week run with HCG will come to an end. I will compare those to see what differences are noted. I will also use this thread to journal any differences I notice in how I feel during the next 12 weeks, or any other changes I notice physical or otherwise. I would also like this to be a civil open discussion on my thoughts and theories, and you guys thoughts and theories on the subject.

Feel free to make predictions to test what you may or may not know, or whatever. Maybe this will help someone else. Maybe it will even pique enough interest that the discrepancies could be studied further by those with the means and education to properly conduct such studies, and eventually we could all have science driven fact on the matter. Until then, this is best that I can offer with my limitations.

Thanks for reading and feel free to chime in!!

@dbossa @increasemyt
I would love for you guys to get in on this discussion.

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I doubt that you’ll feel any difference at all, but your E2 will come back little higher than without it, and your T even more mildly elevated.

That’s something we should be able to definitively prove or disprove. Do you think I would still not feel a difference if T and E2 levels rise a bit?

I doubt it. I doubt that they will change enough to be felt. I think a guy has to be really sensitive to those changes or on the razor’s edge without it. I think some guys have bodies that know it’s not LH, and so it doesn’t sit well with them. Or it could be some other random thing. I can’t take curcumin or eat ginger, but galangal (Thai ginger) is okay. What’s the difference? Heck if I know, but my body thinks that they are unrelated to each other.

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I’ll be interested to see the results as well. I’m just beginning my TRT journey and starting without HCG since I am indifferent about fertility/testicular atrophy, but considering adding in later as a test to see if it makes me feel better.

Been doing basically the same experiment on myself. Got back on TRT in Feb after 3 month break (was on T + HCG prior for 2.5 yrs). Just started HCG back up beginning of June and not noticing any difference except gaining some size back from atrophied testicles.

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Have you had labs run again since you’ve been on HCG? If so, have you noted any differences?

Got blood taken for labs the day I went in to get the HCG, so I have those results as a baseline. Will get my next labs in 3 months which will allow ample time for everything to stabilize.

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Why did you take a break? I’ve been on TRT for three weeks and do about 180 mg of test cyp a week, and 500iu of HCG. When I started they prescribed me an AI, but after I told them I didn’t want to take it they suggested I lower the HCG dose to the lowest minimum effective dose, from 1000iu a week to 500iu. Stating that it will raise estrogen conversation a bit.

This will be interesting. I recently dropped HCG after being on for years. Wanted to really see if I felt a difference and what my bloods looked like. For me I feel better without it and my blood pressure dropped quite a bit. Here are some bloods from early March while on HCG and from last week being off since last bloods. This is on 80mg week.

March
Total T 999 Range 270-1-70
Free T 182.7.5 Range 48.2-169
BioT 437.6 Range 113.1-397.7
SHBG 50.2 Range 14.6-94.6
Albumin 4.4 Range 3.5-5.0

June
Total T 801
Free T 201.5
Bio T 461.7
Shbg 28.6
Albumin 4.2

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Your range of total t went to 999 on just 80 mg of test a week?

I knew HCG made a difference in hormone levels but didn’t realize it would be that much. Does HCG affect SHBG? You dropped almost in half after dropping the HCG.

999 was 80 mg week with 500 iu hcg week. 801 with just 80mg of T. I’ve always been very responsive to any medication I take. I just had an appt with a new doc and he was pretty surprised at my dose and total t as well.
I honestly have no idea about the SHBG.

I’m on my third week of TRT and I am on 180 mg of test cyp a week and 500 iu of HCG, really wondering where my levels are right now with that in mind. Also your free T is over range with just the 80mg? Thats pretty crazy too.

I have heard that it does. Which im not looking forward to if and whenever I use HCG to have a child. I have higher SHBG to begin with.

Thats interesting. Makes me wonder if it would help some with those that have low SHBG. @bkb333 have you tried without HCG at all? Wonder if dropping it would drop your SHBG.

HCG does indeed affect SHBG; I would not be using it if I didn’t care about fertility, but that’s a huge area of concern for me + my wife. I would probably never forgive myself if I lost my fertility because of T.

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You can also look into having a cryo bank preserve sperm if that is a concern.

I thought about that – from what I recall, it was pretty expensive? Not just the upfront cost but the cost over time. HCG, by comparison, is super, super cheap. I also had my sperm tested in the fall (pre-T) and my count was OK (fertile) but not all that strong. So I don’t even know if I was really starting from a strong place :slightly_frowning_face: I’ve read some about HMG being used, so I may consider that down the road. We aren’t in a rush to have kids right now – likely a couple years from now.

I don’t really know the costs but my sister runs a cryo bank in California. I don’t understand why they would charge so much for that. I thought it was something that was fairly cheap and readily available for anyone having fertility issues. Never heard of HMG before. I hear that people can be on TRT for a few years and then later introduce HCG or other things to help fertility without issue, but I can understand your concern of why the possibility you can become impotent, even with that is such a worry.