[quote]usmccds423 wrote:
Maybe this will help: Improvement in insulin sensitivity following a 1-year lifestyle intervention program in viscerally obese men: contribution of abdominal adiposity - PubMed
Clinical Science: Improvement in insulin sensitivity following a 1-year lifestyle intervention program in viscerally obese men: contribution of abdominal adiposity.Authors:Anne-Laure Borela
Julie-Anne Nazarea
Jessica Smitha
Natalie Almérasa
Angelo Tremblaya, b
Jean Bergeronc
Paul Poiriera
Jean-Pierre Desprésa, b, ⁎.
Affiliation:a Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec, QC, Canada
b Division of Kinesiology, Department of Social and Preventive Medicine, Université Laval, Québec, QC, Canada
c Lipid Research Center, CHUL Research Center, Québec, QC, Canada.
Note:Authors contribution: Anne-Laure Borel: data analysis, data interpretation and manuscript writing. Julie-Anne Nazare: data interpretation and critical revision. Jessica Smith: data interpretation and critical revision. Natalie Alméras: design conception, conduct of the study, and critical revision. Angelo Tremblay: design conception and critical revision. Jean Bergeron: design conception and critical revision. Paul Poirier: design conception and critical revision. Jean-Pierre Després: design conception, conduct of the study, data interpretation, critical revision…
Source:In Metabolism 61(2):262-272.
Publisher:Elsevier Inc…
Abstract:The objectives of the study were to quantify the effect of a 1-year healthy eating?physical activity/exercise lifestyle modification program on insulin sensitivity in viscerally obese men classified according to their glucose tolerance status and to evaluate the respective contributions of changes in body fat distribution vs changes in cardiorespiratory fitness (CRF) to the improvements in indices of plasma glucose/insulin homeostasis. Abdominally obese, dyslipidemic men (waist circumference ≥90 cm, triglycerides ≥1.69 mmol/L, and/or high-density lipoprotein cholesterol <1.03 mmol/L) were recruited. The 1-year intervention/evaluation was completed by 104 men.
Body weight, composition, and fat distribution were assessed by dual-energy x-ray absorptiometry/computed tomography. Cardiorespiratory fitness and cardiometabolic risk profile were measured. After 1 year, insulin sensitivity improved in association with decreases in both visceral (VAT) and subcutaneous adiposity (SAT) as well as with the improvement in CRF, regardless of baseline glucose tolerance. Further analyses were performed according to changes in glucose tolerance status: improvement (group I, n = 39), no change (group N, n = 50), or worsening (group W, n = 15) after 1 year. Groups I and N improved their insulin sensitivity and their CRF, whereas group W did not, while losing less VAT than groups I and N. Multiple regressions showed that reduction in VAT was associated with an improvement in homeostasis model assessment of insulin resistance, whereas reduction in SAT was rather associated with improvement of the insulin sensitivity index of Matsuda.
Changes in CRF were not independently associated with changes in indices of plasma glucose/insulin homeostasis. A 1-year lifestyle intervention improved plasma glucose/insulin homeostasis in viscerally obese men, including those with normal glucose tolerance status at baseline. Changes in SAT and VAT but not in CRF appeared to mediate these improvements…
Document Type:Article.
ISSN:0026-0495.
DOI:10.1016/j.metabol.2011.06.024.
Accession Number:S0026049511002149.
Copyright:Copyright © 2012 Elsevier Inc. All rights reserved…
Database: ScienceDirect.[/quote]
This means nothing since it was done on obese men and it has NOTHING to do with the population we are talking about. It will be wholly rejected as meaningless.