So I’ve been on TRT for almost 6 months now. My clinic started me off at 80mg test cyp a week, split into 2x 40mg subq injections and 2x 500ui HCG a week. I did my 8 week bloodwork and had my 3 month followup in February, they bumped me down to 60mg as my levels were pretty high for them at 1065 pmol/L. I recently did another round of bloodwork and my free test is sitting at 1266.5pmol/L. Had anyone ever had this happen before? It seems weird to me that my levels would increase after lowering my dosage.
This kind of thing happens all the time. TRT is not a set and forget therapy, your levels will still fluctuate and do some adjustments are needed every now and then.
Yeah I expected that, just surprised me to see my current levels above my higher dosage.
You have given no context. Injection frequency the same. Same trough measurement?
FT test type and ref range? Share the lab work TT, SHBG, fT with ref ranges and protocol and test timing before and after if you want more than a hand waving answer.
Are you still injecting SubQ? It’s a known issue that subq injections have an inconsistent release curve
I am, funny enough I hate needles lol subq makes it easier for me to inject.
Please elaborate.
Source?
Well I’ll be damned. I read it somewhere but now I can’t find it… After reading through a couple dozen articles/PubMed docs I couldn’t find anything so I’m going to say my original stance was wrong.
Why in the world would anyone choose IM injections?
Check out the PK data with Xyosted. While it’s an expensive product the clinical trial data is useful. Given the state of obesity today, one dude’s IM is another dude’s SC with 27g 0.5in pin :-).
I appreciate your honesty.
Definitely measurable elimination half life difference with Xyosted vs TC IM data but we really have to be careful with presence of BA, site of injection.
AUC for 100 mg Test Ester injected will be same but absorption/elimination constants can vary. These cause all kinds of confusion when guys try to reconcile their labs (E7D vs E3.5D) etc etc etc etc.
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https://academic.oup.com/jes/article/1/8/1095/3988127?login=true
Interesting multi-peak behavior on some patients.
How would that cause issues for someone trying to assess their trough? Discuss.
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