Intramuscular vs SubQutaneous Injections for Testosterone

The misinformation on here regarding IM vs SQ injections and resulting serum TT levels is staggering but understandable.

The area under the curve (AUC) will be invariant to injection method (IM vs SQ) for equivalent testosterone ester dose. There can be a measurable difference in pharmacokinetic parameters between the two injection methods as I shared with @Andrewgen_Receptors previously. See this post and posts below. Typical elimination half life for TC is 4.5-7 days for IM and ~8-10 days or so with SQ.

You need to define your blood draw timing with respect to injection timing and understand how your injection frequency affects your testosterone profile vs time as @mnben87 mentioned.

See Fig 1 in linked paper below and my prior posts on pharmacokinetics of injectable testosterone.

Question 1: No.

Question 2: Yes and depends on the elimination half life of the preparation. Rough rule of thumb is 5 half lives to reach stable temporal profile.

Conclusion: most do not calculate and compare AUC between IM and SQ and hence dont understand their mean TT level will be the same on either injection protocol. What they do see is presumably a trough TT value difference and hence incorrectly conclude that SQ is superior or end up with nutty claim that 80 mg of SQ is equivalent to 100 mg IM. They miss that their peak TT was higher on IM and think they got shortchanged compared to SQ based on single time point (presumably the usual trough measurement).

I can make some plots to demonstrate your point @mnben87. But I gather most don’t want or need another chart :rofl:. Easier to just watch a Youtube video by an expert and keep repeating the same lies over and over and over again.

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