While at the doctor’s office I read in the latest copy of Life Extension (Feb. '07) that a recent study showed that fish oil may actually destroy fat cells. I felt guilty stealing the magazine, so I don’t have a cite to the study. Is anyone familiar with this?
(If that’s the case, it would support Poliquin’s recommendation that you consume 15-20 gms. of fish oil daily while on a fat loss diet.)
there was some other study a year or two ago showcasing a new method of either cell microscopy or fluorescence (cant remember) that showed the EPA/DHA compounds (sp?) greatly enhanced cells ability to uptake saturated fatty acids which usually were very reluctant to be uptaken
[quote]CaliforniaLaw wrote:
While at the doctor’s office I read in the latest copy of Life Extension (Feb. '07) that a recent study showed that fish oil may actually destroy fat cells. I felt guilty stealing the magazine, so I don’t have a cite to the study. Is anyone familiar with this?
(If that’s the case, it would support Poliquin’s recommendation that you consume 15-20 gms. of fish oil daily while on a fat loss diet.)[/quote]
Go back to the Dr. and rip that section out. I do it all the time. They don’t care the mags are donated anyways!
[quote]CaliforniaLaw wrote:
While at the doctor’s office I read in the latest copy of Life Extension (Feb. '07) that a recent study showed that fish oil may actually destroy fat cells. I felt guilty stealing the magazine, so I don’t have a cite to the study. Is anyone familiar with this?
(If that’s the case, it would support Poliquin’s recommendation that you consume 15-20 gms. of fish oil daily while on a fat loss diet.)[/quote]
DHA apparently inhibits the ability of pre-adipocytes to differentiate into fat cells, and induces the pre-adipocytes to carry out apoptosis.
[quote]booger wrote:
DHA apparently inhibits the ability of pre-adipocytes to differentiate into fat cells, and induces the pre-adipocytes to carry out apoptosis.[/quote]
Too bad it’s talking about “pre” adipocytes instead of directly affecting adipocytes. The world would go nuts for a fat cell destroying agent!
I believe Poliquin reccomends even more than that…45g/day
[quote]scotty144 wrote:
I believe Poliquin reccomends even more than that…45g/day[/quote]
I read on another message board(won’t name names but it begins with a B and ends with a G .com) That high doses of DHA are cytotoxic. One poster said that DHA(as well as AA, another fatty acid) are highly susceptible to “free radical-catalyzed lipid peroxidation” and that the oxidative damage can lead to “docosanoid-induced neurodegeneration” and possibly neurodegenerative diseases such as alzheimer’s. In lower dosages, however, DHA is a neuroprotectant. He cited these studies:
http://ajp.amjpathol.org/cgi/content...166/5/1283#B64
http://www.jbc.org/cgi/content/abstr...e2=tf_ipsecsha
http://ajp.amjpathol.org/cgi/content/full/166/5/1283"
With this information, I’m considering ceasing my high dosages of fish oil(30+ grams daily) which I began after reading
Poliquin’s article. A healthy mind is far more important than being lean.
[quote]abcd1234 wrote:
scotty144 wrote:
I believe Poliquin reccomends even more than that…45g/day
I read on another message board(won’t name names but it begins with a B and ends with a G .com) That high doses of DHA are cytotoxic. One poster said that DHA(as well as AA, another fatty acid) are highly susceptible to “free radical-catalyzed lipid peroxidation” and that the oxidative damage can lead to “docosanoid-induced neurodegeneration” and possibly neurodegenerative diseases such as alzheimer’s. In lower dosages, however, DHA is a neuroprotectant. He cited these studies:
http://ajp.amjpathol.org/cgi/content...166/5/1283#B64
http://www.jbc.org/cgi/content/abstr...e2=tf_ipsecsha
http://ajp.amjpathol.org/cgi/content/full/166/5/1283"
With this information, I’m considering ceasing my high dosages of fish oil(30+ grams daily) which I began after reading
Poliquin’s article. A healthy mind is far more important than being lean. [/quote]
Considering that the brain is simply made up of a lot of fatty tissue, I wonder if those studies are merely showing how such things can degrade over time as opposed to any type of specific risk factor?
People do a lot of theorizing over these types of things. I suspect that being healthy and getting antioxidants in your diet is what lets you minimize the degredation path. Think about it, living is “degredation path” leading eventually to our deaths.
Heh, isn’t that a pleasant thought!
However, at the same time, as with anything else, there is always the possibility for unknown reactions when amounts consumed are far beyond what a natural person would have been able to consume on a normal diet throughout history.
However, fish have been a staple of human diet for a long long time now.
And in other recent news, Squats get you big.
[quote]abcd1234 wrote:
scotty144 wrote:
I believe Poliquin reccomends even more than that…45g/day
I read on another message board(won’t name names but it begins with a B and ends with a G .com) That high doses of DHA are cytotoxic. One poster said that DHA(as well as AA, another fatty acid) are highly susceptible to “free radical-catalyzed lipid peroxidation” and that the oxidative damage can lead to “docosanoid-induced neurodegeneration” and possibly neurodegenerative diseases such as alzheimer’s. In lower dosages, however, DHA is a neuroprotectant. He cited these studies:
http://ajp.amjpathol.org/cgi/content...166/5/1283#B64
http://www.jbc.org/cgi/content/abstr...e2=tf_ipsecsha
http://ajp.amjpathol.org/cgi/content/full/166/5/1283"
With this information, I’m considering ceasing my high dosages of fish oil(30+ grams daily) which I began after reading
Poliquin’s article. A healthy mind is far more important than being lean. [/quote]
Thats funny because I’ve been taking very high doses of fish oil for the past six years and haven’t noticed any negative side effects- other than the positive ones, like preventing inflammation and my cholesterol levels going down, etc. I really wouldn’t pay much attention to those studies. There are many tribes that practically live off of fish. I don’t see them dying of any diseases due to their high consumption of DHA. By the way, did any of those studies use a clean source of fish oil? Some fish oil-based supplements contain mercury or other toxins, which can be harmful in concentrated forms, which could be another thing the study isn’t telling us.
[quote]Cthulhu wrote:
There are many tribes that practically live off of fish.[/quote]
There’s a word for that. Peoples that subsist on fish are ichthyophagous.
[quote]nephorm wrote:
Cthulhu wrote:
There are many tribes that practically live off of fish.
There’s a word for that. Peoples that subsist on fish are ichthyophagous.[/quote]
Wow Nephorm, that really is you in your avatar! 
Kim HK, Della-Fera M, Lin J, Baile CA.
Department of Animal and Dairy Science, and 3Department of Foods and Nutrition, University of Georgia, Athens, GA 30602.
Docosahexaenoic acid (DHA, C22:6), a (n-3) fatty acid in fish oil, has been shown to decrease body fat and fat accumulation in rodents. We investigated the direct effect of DHA on cell growth, differentiation, apoptosis, and lipolysis using 3T3-L1 adipocytes. Cells were treated with 25-200 mumol/L DHA containing 0.2 mmol/L alpha-tocopherol or bovine serum albumin vehicle as a control. Proliferation of preconfluent preadipocytes was not affected by the DHA treatment. When added to postconfluent preadipocytes, all concentrations of DHA inhibited differentiation-associated mitotic clonal expansion (P < 0.01). Postconfluent preadipocytes demonstrated apoptosis after 48 h with 100 mumol/L DHA and after 24 and 48 h with 200 mumol/L DHA (P < 0.01). Differentiation was examined by Oil Red O staining and glycerol-3-phosphate dehydrogenase (GPDH) activity after DHA treatment for 6 d. DHA decreased mean droplet size and percent lipid area in a dose-dependent manner (P < 0.01). GPDH activity was also decreased by DHA treatment (P < 0.01). In fully differentiated adipocytes, DHA increased basal lipolysis compared with the control (P < 0.01). These results demonstrate that DHA may exert its antiobesity effect by inhibiting differentiation to adipocytes, inducing apoptosis in postconfluent preadipocytes and promoting lipolysis.
PMID: 17116704 [PubMed - indexed for MEDLINE]
This is the actual study cited in the LifeExtension promotional/propaganda rag.
[quote]nephorm wrote:
Cthulhu wrote:
There are many tribes that practically live off of fish.
There’s a word for that. Peoples that subsist on fish are ichthyophagous.[/quote]
Dang, so my Palyentology professor was right that wasn’t the right spelling.
[quote]Keyser Soze wrote:
Keyser, How did you get my wife, as a teenager, on your avitar?