[quote]rds63799 wrote:
[quote]Mr. Walkway wrote:
that’s like saying “don’t the sterons totally shrink your dick tho brah?”
[/quote]
fair enough, care to elaborate? DNP is not something I know a lot about (add it to the list, lol)[/quote]
follow that link
I thought DNP was dangerous because it didn’t have a feedback loop in your body. It’ll just keep heating you up more and more and more.
[quote]Mr. Walkway wrote:
[quote]rds63799 wrote:
[quote]Mr. Walkway wrote:
that’s like saying “don’t the sterons totally shrink your dick tho brah?”
[/quote]
fair enough, care to elaborate? DNP is not something I know a lot about (add it to the list, lol)[/quote]
follow that link[/quote]
oh very good
[quote]rds63799 wrote:
doesn’t it totally fuck up your mitochondria? You are the first person I’ve ever heard say it was safer than clen, although I know clen is baaaad[/quote]
First, I totally agree that bushy is an extremely bright dude and I didn’t mean to suggest otherwise or in any way insinuate that he doesn’t know what the deal is with most performance enhancers. That was just my initial impression based on your summary.
For this ^, DNP functions as a protonophore which uncouples oxidative phosphorylation by inhibiting the formation of the proton gradient between the inter-membrane space and mitochondrial matrix; this inhibition attenuates the proton-motive force that is used to power ATP synthase and results in a recurring dissipation of oxidation energy as heat.
In English, and while not 100% medically accurate but serviceable: DNP takes oxidative phosphorylation and snaps that phrase in half. In other words, it prevents the energy derived from oxidation from being used to phosphorylate (add phosphates) to ADP (adenosine di-phosphate) to generate ATP (tri-phosphate). What happens is, during energy production, an imbalance in protons (hydrogen cations; H+) is produced across the membranes in mitochondrial. To catalyze ADP → ATP, these protons are allowed to pour back in through an enzyme known as ATP synthase, with this transition powering the enzyme to do its thang. DNP prevents this buildup of H+ from occurring by making the mitochondrial membranes “leaky” and thus allowing the protons to dissipate as heat rather than being used to drive ATP synthase. As a consequence, metabolism becomes much less efficient and the body needs to burn more calories to generate enough ATP to maintain the status quo.
(Youtube-ing the Khan Academy presentation on cellular respiration will clarify the process of oxidative phosphorylation better than I can, I think)
The inefficiency of this process is dose-dependent, with 200mg DNP raising metabolism ~20% and 500mg DNP having been shown to elevate metbaolism ~60%.
This sounds funky, but it is actually a naturally occurring phenomenon (Google: uncoupling proteins). Uncoupling Protein 1 (UCP1, formerly thermogenin) is found in brown adipose tissue in infants and hibernating mammals and causes what is called “non-shivering thermogenesis” - or, the generation of heat without shivering.
There are a handful of uncoupling proteins known, but that one is the most famous. DNP is, to my knowledge, the most potent uncoupler known at this point by a fairly substantial degree.
Also, while I’m not an expert on long-term effects of clen, increased heart rate/contractility and trophic signals from B-adrenergic stimulation are known inducers of cardiac hypertrophy.
While the above is most often the result of impaired cardiac function or chronically-increased workload (and the first step in a series of degenerative adaptations leading to heart failure), I wouldn’t be surprised if drugs have been seen to cause similar deleterious effects.
OP
See how fat you can get your wife. It will take some effort, and you’ll need to purchase a home deep fryer and possibly some stock in the old ladies fast food establishment of choice. Divorce her through death as surely her heart will explode, or maybe her rib cage will collapse under her own weight while sleeping one night, who knows but apparently that sounds more morally acceptable than actually trying to make her skinny and attractive. (that might be a run on sentence)
PS. How a normal non-amazonian woman can weight 300lbs takes some serious doing on her part. I mean i would love to drink Guinness and whiskey every night but i dont like headaches in the morning, so i dont do it. Is it hard, NO, because i have to work in the mornings and it’s unhealthy as fuck to drink every night. So how anyone can say “Im addicted to food” is beyond ridiculous and really just means “I’m a weak minded fat body pussy of a human” Get addicted to drinking bleach and fuck off.
Wowza!!!
Page 14 already? Dayummmmm!
Won’t bother to read them all but I hope, OP, that you’d had shit load of good/crap advice from fellow Tnationers.
Dear God I didn’t make a joke on page one (which was only yesterday!) out of fear of looking like a jerk…
so here goes:
If a woman is 300 lbs then you’re already having sex with two women anyway.
[quote]csulli wrote:
I thought DNP was dangerous because it didn’t have a feedback loop in your body. It’ll just keep heating you up more and more and more.[/quote]
Yes, the two biggest risks in using DNP are 1) finding a supplier who doesn’t know how to dose products correctly and 2) being impatient and starting too high/ramping too quickly before assessing tolerance.
The original studies on DNP indicate that once body temp reaches 99.3F (or thereabouts, it’s been a while), one is at the threshold of safe physiological tolerance and shouldn’t proceed any higher (ideally decreasing the dosage) due to a significantly increased risk of adverse effects.
[quote]csulli wrote:
[quote]audiogarden1 wrote:
[quote]csulli wrote:
[quote]Mr. Walkway wrote:
way to prove your point with an ad hominem… lmao… you are comedy
[/quote]
lmao, way to resort to ad hominem to prove your point you dumb bastard[/quote]
Man, i cant believe how worked up you are over this. Its either that, or you’re covering up your lack of any real insight with blatant and offensive name-calling.
I’d hate to see how you’d react if somebody slapped the gameboy out of your hands…[/quote]
[quote]yolo84 wrote:
sorry but is there a cliff notes as to the dispute between you two?
csulli you always seem so even tempered[/quote]
Lol sorry I didnt mean to troll you two. Whenever I resort to actual insults is a tell when you know I’m not taking whatever it is very seriously and just trying to bait whoever the nemesis is. I do love a good internet fight every once in a while. In all seriousness though it does concern me the way he addresses certain very respectful and beneficial posters on here with extreme rudeness. I do hate seeing that.[/quote]
Ive never seen Walkway post anything that i didnt think was either warranted, useful, or funny.
Good to see you took your time out, counted back from ten and cooled down.
Oh, and in case it hasn’t been mentioned yet: the quickest way to get your wife looking fuckable again is to put her back on the market.
It’s a huge cliche, I know, but it’s the troof.
[quote]anonym wrote:
[quote]rds63799 wrote:
doesn’t it totally fuck up your mitochondria? You are the first person I’ve ever heard say it was safer than clen, although I know clen is baaaad[/quote]
First, I totally agree that bushy is an extremely bright dude and I didn’t mean to suggest otherwise or in any way insinuate that he doesn’t know what the deal is with most performance enhancers. That was just my initial impression based on your summary.
For this ^, DNP functions as a protonophore which uncouples oxidative phosphorylation by inhibiting the formation of the proton gradient between the inter-membrane space and mitochondrial matrix; this inhibition attenuates the proton-motive force that is used to power ATP synthase and results in a recurring dissipation of oxidation energy as heat.
In English, and while not 100% medically accurate but serviceable: DNP takes oxidative phosphorylation and snaps that phrase in half. In other words, it prevents the energy derived from oxidation from being used to phosphorylate (add phosphates) to ADP (adenosine di-phosphate) to generate ATP (tri-phosphate). What happens is, during energy production, an imbalance in protons (hydrogen cations; H+) is produced across the membranes in mitochondrial. To catalyze ADP → ATP, these protons are allowed to pour back in through an enzyme known as ATP synthase, with this transition powering the enzyme to do its thang. DNP prevents this buildup of H+ from occurring by making the mitochondrial membranes “leaky” and thus allowing the protons to dissipate as heat rather than being used to drive ATP synthase. As a consequence, metabolism becomes much less efficient and the body needs to burn more calories to generate enough ATP to maintain the status quo.
(Youtube-ing the Khan Academy presentation on cellular respiration will clarify the process of oxidative phosphorylation better than I can, I think)
The inefficiency of this process is dose-dependent, with 200mg DNP raising metabolism ~20% and 500mg DNP having been shown to elevate metbaolism ~60%.
This sounds funky, but it is actually a naturally occurring phenomenon (Google: uncoupling proteins). Uncoupling Protein 1 (UCP1, formerly thermogenin) is found in brown adipose tissue in infants and hibernating mammals and causes what is called “non-shivering thermogenesis” - or, the generation of heat without shivering.
There are a handful of uncoupling proteins known, but that one is the most famous. DNP is, to my knowledge, the most potent uncoupler known at this point by a fairly substantial degree.[/quote]
my totally-not-gay-man-crush on you grows more powerful every day.
So do the dangers just come from the body overheating? Or does the whole process have some sort of inherent danger? I’ve heard the mitochondria get badly damaged, and that it can even damage your DNA but I don’t know whether there’s any truth to that.
has anyone considered maybe the op’s wife just prefers the full house look for herself?
[quote]Dr. Pangloss wrote:
has anyone considered maybe the op’s wife just prefers the full house look for herself?[/quote]
I think she has a crush on Eliteballa3. I hear he likes a full figured woman.
[quote]Aggv wrote:
OP
See how fat you can get your wife. It will take some effort, and you’ll need to purchase a home deep fryer and possibly some stock in the old ladies fast food establishment of choice. Divorce her through death as surely her heart will explode, or maybe her rib cage will collapse under her own weight while sleeping one night, who knows but apparently that sounds more morally acceptable than actually trying to make her skinny and attractive. (that might be a run on sentence)
[/quote]
Ahahahahha, n1.
[quote]rds63799 wrote:
my totally-not-gay-man-crush on you grows more powerful every day.[/quote]
Oh, you tease…
[quote]rds63799 wrote:
So do the dangers just come from the body overheating? Or does the whole process have some sort of inherent danger? I’ve heard the mitochondria get badly damaged, and that it can even damage your DNA but I don’t know whether there’s any truth to that.[/quote]
Overheating and dehydration, from the looks of it. A body temp of 99.3F (or so) indicates that the uncoupling is outpacing the body’s ability to dissipate the heat. While this is the most “famous” danger of DNP, dehydration is a very real concern, as well, due to the 24/7 sweating (also consider the electrolyte imbalances that can result from this).
I’d imagine most cases of DNP going wrong are the result of a) people ramping their dosage too quickly (DNP’s ~36hr half-life makes most suggest that one wait AT LEAST 3 - 4 days before considering an increase) or b) not drinking enough water, either in general or in addition to hitting a hard gym session to facilitate caloric expenditure.
As far as DNA damage goes: uncoupling proteins have been demonstrated to reduce the production of reactive oxygen species (ROS), the generation of which is, in part, tightly linked to mitochondrial membrane potential. Use of uncoupling proteins has been associated with reduced ROS production, oxidative stress to tissues, damage to DNA and effects mimicking caloric restriction. Cardio- and neuro-protective effects have been demonstrated in cases of ischemia, as well, where insufficient oxygen is available to accept upaired electrons at complex I of the ETC, which would otherwise result in an increased production of superoxide radicals.
[quote]DarkNinjaa wrote:
Wowza!!!
Page 14 already? Dayummmmm!
Won’t bother to read them all but I hope, OP, that you’d had shit load of good/crap advice from fellow Tnationers.[/quote]
Go back and read it all.
Do it.
[quote]bpick86 wrote:
Off topic ( not that it has mattered to this point) but anyone think this is legit, read post 44
Apparently people missed this post, but this was absolute gold.
[quote]super saiyan wrote:
[quote]DarkNinjaa wrote:
Wowza!!!
Page 14 already? Dayummmmm!
Won’t bother to read them all but I hope, OP, that you’d had shit load of good/crap advice from fellow Tnationers.[/quote]
Go back and read it all.
Do it.[/quote]
I’m glad I did just now. My favorite matchup was yolo vs usmccds. I wish I had someone to argue with right now.
nm I do
[quote]DarkNinjaa wrote:
Wowza!!!
Page 14 already? Dayummmmm!
Won’t bother to read them all but I hope, OP, that you’d had shit load of good/crap advice from fellow Tnationers.[/quote]
Solid avatar. I think it’s awesome that you post pics of other women and try to pass it off as your own