Difference in Peak/Trough On Twice Weekly?

[johann77]

Maybe this helps to answer the peak trough question

Injection Frequency - Pharmacokinetics Perspective

A frequent topic is the frequency of T injection. Below you find a simulation of how T builds up in the system and how high the variability is between injections with different injection frequencies. In subq steady-state levels are reached after about 45 days. Variability (peak vs trough) of 100 mg T Cyp (total per week): weekly injection ~300 ng/dL 3x weekly injection ~80 ng/dL daily injection ~20 ng/dL Natural variability throughout the day (diurnal variability) is typically around 100 …