Hey Bill what do you think ? This looks like an interesting alternative to clomid…
Life Sci 1997;61(18):1783-8
" Deprenyl stimulates the release of luteinizing hormone from the pituitary in vitro.
MohanKumar PS, MohanKumar SM, Quadri SK
Department of Anatomy and Physiology, Kansas State University, Manhattan 66506, USA.
The direct effects of deprenyl on the pituitary were investigated by measuring the release of luteinizing hormone (LH) from the pituitary
glands of male Sprague-Dawley rats in vitro. Basal release of LH was determined by incubating the pituitaries in Krebs-Ringer Henseleit (KRH)
solution with 0, 0.1, 1, or 10 mM of deprenyl for 1 h. In the control group, LH release was not different in pre- and posttreatment periods.
In contrast, in the 10 mM group, LH release increased by 436% (p<0.01). Incubation of pituitaries with 0.1 or 1 mM deprenyl did not alter LH
release. It is concluded that deprenyl a monoamine oxidase inhibitor, can also act directly on the pituitary."
Nice find. 2 concerns: First, since it was only effective at the highest dose, that might translate to a whole lotta deprenyl to take orally. Second, deprenyl is non-specific. The doses needed for LH increase may wreak havoc on the rest of the system. I’ll look into it more, though.
Coyote: It may be that deprenyl increases LH, but if you
read through all the research on deprenyl, it is not at all
clear that it is safe - especially at higher dosages. Same
thing with L-dopa: bodybuilders take L-dopa to increase
GH production but L-dopa kills dopamine producing brain
cells, so this is really stupid. They are going to end up
inducing parkinsons disease in themselves. You can increase
LH production with tribulus terrestris (at least the high
quality kind like Tribex).
Another thing to look at is that there is a world of
difference between an acute (immediate, short term)
increase in LH resulting from a drug or hormone, and
the long term effect. In fact, they are often opposite…
e.g., progesterone gives an acute response increasing
LH production, but a chronic (long term) response
decreasing it drastically.
There are a LOT of things affecting LH release… but very
few of them are favorably manipulated chronically to
achieve a chronic increase.
I don’t think it’s been noted that people using selegiline
(Deprenyl) have unusually high T levels which suggests
that there is no chronic benefit with regard to LH.