[quote]m00se wrote:
I’m looking at taking Rhodiola, and I’m curious as to any interaction between that and the piperine in curcumin.
I found this: http://findarticles.com/p/articles/mi_hb3363/is_1-2_15/ai_n29416473/
(page 6 seemed to be what I was looking for)
" When combination of Rhodiola and piperine containing extract (RPE) was tested an abnormal dose dependant effect was observed–the activity of the preparation is decreasing when the dose is increasing in the range of doses 10-50 mg/kg RPE, Table 1, Fig. 3.
Combination of piperine with Rhodiola distorts pharmacological effect of Rhodiola most probably due to changes of pharmacokinetic profile of rhodioloside and rosavine (Table 2).
After the administration of RPE the absorption of Rosavin into the blood is much higher than it is after administration of RR. The maximal concentration of Rosavin is increasing in 1.8 times at the 1.4 times dose increase. The pharmacokinetic of rhodioloside is completely differently changed, in particular a longer elimination time. It is also absorbed faster, but longer eliminated from the blood. However in both cases apparent volume of distribution is decreased, because of decreased bioavailability (F). It is known that piperine impairs cytochrome P4501A1 activity by direct interaction with the enzyme (Reen et al., 1996). It has a biphasic effect upon cytochrome P450 monooxygenase activity with an initial suppression followed by induction. Treatment of D. melanogaster with P. nigrum extract led to a greater than 2-fold upregulation of transcription of the cytochrome P450 phase I metabolism genes Cyp 6a8, Cyp 9b2, and Cyp 12dl (Jensen et al., 2006). It can increase (Lala et al., 2004; Atal et al., 1985) or decrease (Hiwale et al., 2002) bioavailability of co-administrated drugs, thereby adversely affecting their therapeutic efficacy. Two other bisalkaloids, dipiper-amides D and E, were recently isolated as potent inhibitors of a drug metabolizing enzyme cytochrome P450 (CYP) 3A4 from Piper nigrum (Tsukamoto et al., 2002). Thus, we conclude that combination of Rhodiola with piperine (RPE) cannot provide predictable therapeutic effect due to herb-herb interaction in the dose level of piperine higher of 0.08 mg/kg (in rat, that is theoretically equivalent to dose of 0.01 mg/kg in human). Moreover, concomitant treatment of this preparation (RPE) with other drugs should also be taken into consideration."
But honestly, I’m just having a hard time figuring out what that all MEANS?
Can anyone help decipher this?
Thx![/quote]
mOOse,
It appears that piperine increases the uptake of rosavin into the tissues but does the opposite with rhodioloside. Rosavin is the main active ingredient in RR anyway, so I dont think there is any reason to be concerned about a negative interaction (at least until more research is conducted in humans). But just to be sure, you could stagger your doses of each supplement so there is minimal overlap in the blood.
Here is an excerpt of a piece I wrote last year on RR (Rhodiola rosea):
Initially salidroside (rhodioloside) was thought to be the compound responsible for the Rhodiola roseaâ??s unique pharmacological properties, however more recent research has determined that three water-soluble cinnamyl glycosides (rosavin, rosin, and rosarin), collectively referred to as the â??rosavinsâ??, are largely responsible for the herbâ??s myriad effects on human physiology (2). Indeed, salidroside is common throughout the 200 different species of Rhodiola (2,3), but only Rhodiola rosea is known to contain the rosavins. In addition, recent evidence suggests that tyrosol (a phenylethanol derivative also found in olive oil) has powerful pharmacologic effects as well (4). Other important chemical compounds found in Rhodiola rosea include several flavonoids (rodiolin, rodionin, rodiosin, acetylrodalgin, tricin), monoterpernes (rosiridol, rosaridin), triterpenes (daucosterol, beta-sitosterol) and phenolic acids (chlorogenic, hydroxycinnamic, gallic).
Refs:
2. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern. Med. Rev. 6(3):293-302, 2001.
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Abidov M, Crendal F, Grachev S, Seifulla RD, and TN Ziegenfuss. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles Bull. Exp. Biol. Med. 136(6):585-7, 2003.
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Di Benedetto R, Varì R, Scazzocchio B, Filesi C, Santangelo C, Giovannini C, Matarrese P, D’Archivio M, Masella R. Tyrosol, the major extra virgin olive oil compound, restored intracellular antioxidant defences in spite of its weak antioxidative effectiveness. Nutr Metab Cardiovasc Dis. 2007 Sep;17(7):535-45. Epub 2006 Aug 22.
TZ
I have gotten into the habit of nightly Motrin use and knew that was not a good thing.