How is appetite?
It would be interesting to see the results following a psmf diet.
Slightly down. I just took my second 0.125 mg dose. I think my stomach looks a bit leaner.
My struggle is getting up at night super hungry and then eating. I can eat very little during the day, but as soon as I lay down for bed I become ravenous. The part that sucks is that it keeps me from falling asleep, but if I eat, I usually fall asleep quickly. So I have the choice of eating or sleeping (or at least falling asleep faster).
Yesterday, I ate around 1900 calories. Wasn’t hungry at all during the day. Did about a 500 calorie workout (cardio was 350 calories, lifting I figure about 150 cals). So a pretty big deficit. About 20 minutes in bed, and the hunger came. I tried to ignore it. About an hour and a half later I finally got up and ate around 700 calories.
I’ve gotten a lot better about not getting up to eat though. It used to be almost every day. This week, I only got up last night to eat. I’ve been working on this for awhile now though. I was down to probably 2 nights a week before the semaglutide.
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You’ve probably tried this but any success just putting your largest meal here and eating less during the day? I’ve thought of doing that, since I want to eat around bedtime as well. So allot 700-800 cal for that meal and eat less during the daytime?
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That is what I do. I think it’s more psychological than anything. The bed is a hunger trigger. I need to break that trigger, which I’ve been trying to do.
I also, just need to have damage control foods for it. High protein, and or low calorie dense items.
I’d prefer to just be able to fall asleep though.
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True that lol
When do you dose? Do you feel anything the hours following? Any reason to take it at night?
I’ve been doing twice a week (0.125 mg per time). Not much TBH with that dose. I do get more burps I think. Other than that, not much so far. Maybe, a bit less hunger. I seem to be able to hear my stomach a bit more.
I think what you hear about nausea or other negative sides is basically people that have negative sides reporting more than people that don’t have sides. It makes it seem like the drug is far more likely to have these negative side effects.
We will see what pops up as I ramp up the dose.
How is the progress for those using it?
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Tonight will be the 4th pin of semaglutide. I am doing 0.125 mg twice a week (so about two weeks). The only negative side effect I’ve had is burps so far.
I’ve lost about 3 lbs so far on it. I don’t think I was holding much water as I was cutting before I started it.
On the dose I am on, the hunger reduction for me is low, but noticeable, so far (after today’s pin, it will be about 80% of peak build up in my system).
A small reduction in appetite at my dose isn’t necessarily a bad thing. I am not interested in not being hungry or interested in food at all, as I’d probably be not eating enough protein, and losing too fast (which involves strength loss, and perhaps muscle).
I do think I’ll probably go up to 0.375 mg per week after 4 weeks to speed things up a little more. I don’t see myself going more than 0.5 mg/wk.
I think for me personally, the difference between successful cuts, or my many un-succesful ones has only been a few hundred calories a day. Hopefully this will work well to make it a successful cut.
Aside from the appetite suppression and slower gut motility are there, other mechanisms by which you lose fat?
Is there something the rise in Insulin does directly? I have read that insulin inhibits lipolysis but, I believe Semaglutide does not do it enough (could be wrong).
Also, that when you’re in calorie deficit you release glucagon burning fat storage but, semaglutide suppresses glucagon so how does the body get hormonal signals to burn fat.
Would being leaner have a more direct effect on fatloss?
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I believe this to be correct. I think the appetite suppression is enough to over power the contradictory effects from enhanced insulin secretion. I’d guess the amount of enhancement is related to the dose.
My personal hypothesis on using semaglutide is to use the minimum effective dose (for someone like me). Someone like me isn’t the typical user. I am already in good shape. If I can keep losing the lbs/wk I want, why go up? Going up would cause more loss, but likely more muscle. For someone 100 lbs overweight, this strategy might not be as good.
Not sure on this. I am guessing this happens also with very low calorie weight loss diets.
I’ve read in one of the studies, that the better shape the person was in the better results they got. Now these are all people that are very out of shape, so IDK if that translates to someone looking to go from in shape to jacked?
My understanding was the drug only stimulates an insulin release in the presence of blood sugar. I noticed with Liraglutide that if I took it too soon after eating I would go hypo almost right away. I have had a couple bought of hypo BS on Sema after very large meals, but otherwise no issues
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I tried liraglutide, starting with .10 mg a few days of the week. Saw no difference. I tried doubling the dose at .20. Still no difference. I bough this from the same source as @swoops39 and was hoping for the same appetite shutdown as mentioned. Does liraglutide have a compounding effect as far as taking some time of dosing consistently before being effective? I’m curious if this is the thing, as I have not been consistent with it (due to travel), but was under the impression it it an immediate effect with a short half life. Perhaps increase the dosage another +.10 mg?
Any shared experience and advice appreciated.
Not much if dosing once a day. The half life is about 13 hours. Let’s just keep it simple and say 12 hours, because that goes into 1 day twice.
Day 1: inject 0.2
Day 2: inject 0.2 + (0.2/4) = 0.25 (I am dividing by 4 because it is two half lives)
Day 3: inject 0.2 + (.25/4) = .2625
Day 4: inject 0.2 + (.2625/4) = .26563
Day 5: inject 0.2 + (.266/4) = .26641
As you can see you are near steady state at day 5, and your effective dose is only like 33% more than the day 1. I’ll let you be the judge on if that is significant or not.
I should make an update on my post about the dosing. I bought two new packs from PS and they def don’t feel like the first ones I did. the old pack, .1mg nightly was all I needed to feel the effects. Now I’m taking 1mg daily don’t feel anything side-effect wise, just less hunger. Also insanely tired; like all I want is sleep. Monster helps for about 2 hours, then it’s back to yawning. Sucks. I force myself through work and barely get workouts in. It’s been 2 weeks, down about 8 lbs, and I’m going to try to lower to .5mg now that I’ve built it up for a bit (I’m not sure if that will work or what the issue is).
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For me, I think my eating is more habitual than hunger driven. I get hungry while laying in bed. All day long I am not very hungry. Then I lay down and boom hunger. It seems tough to sleep with how hungry I am. I am close to ordering a lock for the fridge, and one for the pantry (that my wife would lock and open again in the morning). If food isn’t an easy option I don’t get hungry laying in bed (vacations I don’t have this issue).
I know from what you posted before that it seems your eating is also night time eating, or habitual eating. I find semaglutide helps with normal hunger based eating, but not as much the habitual eating.
Yeah it’s for sure habitual/emotional. I rarely eat because I’m hungry, it’s usually because I’m craving something or thinking about food. The GLP’s take that constant thought about food away, more so than removing the hunger, although they have helped with that too. Now I get actual hunger cues.
I’m a little nervous about this, meaning if I want to eat normally and think about food normally I’ll need to take this forever, kinda like my TRT. Not sure I’m cool with that
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I’ll throw my update in there as well. I purchased Liraglutide from PS and honestly felt nothing from it. The vials might as well have been all water.
In comparison, I did respond to Semaglutide. It does not surpress my appetite much, but I would say it curbs it a bit, and it seems I can get away with more calories than I do without it. So while it doesn’t shut down appetite like I would like it to, it helps there a bit, and seems to increase calorie expenditure a bit as well. This has been my personal experience, at least.
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I wonder if they changed something? Or started diluting it because of demand? IDK