Case of The Myth

I think everyone should just calm down. The Myth came in with a slight faux pas that has been escalated by upset members. I say leave it be and let everyone own their mistakes.

Everyone is entitled to refusing medical treatment or advice at any time. A no thank you might have been better but I think his frustration with this forum is shared among many. He’s just one of the few to have to the balls and nothing to lose to say it.

We don’t have to agree with everything that is suggested here but without the voice of the contributors here there wouldn’t be much to piece together all the questions that come with TRT. I certainly don’t listen to most of it but there are several things that either answered questions I had or directed me to find out the truth and I find that invaluable. The main contributor in this forum has worked his ass off to bring you what he feels is the best information you can receive. This should be valued for that effort even if not heeded.

If you have any further questions I’m happy to help but please let’s get this fire under control.

Funny stuff gents, I’ll get right on that AI so I don’t get too bitchy.

To clarify, I never interpreted KSMan’s thyroid comment to be a request for actual test results. I was probably too quick to dismiss it out of hand but I don’t have the test results, just the assurance (admittedly dubious) from my GP that my thyroid function has been fine for the last so many years. I didn’t want the question of hypothyroidism to become an issue and to sidetrack the discussion, and, of course, that’s exactly what happened. It was never my intent to ignore advice given freely and generously. Live and learn right?

I get tested again in ten weeks and will certainly ask for thyroid results then. In the meantime, feel free to comment, to make suggestions, or to otherwise generally malign me at will, or specifically if the spirit moves.

The Myth

Pro HCG and AI club here. As stated above, seems like many important hormones are produced or supported by the testicles. Just the thought of completely shutting down organs long term spooks me.

Call the doctor and request copies of all of your labs. You will wish that you had some pre trt baseline numbers to refer to as your journey progresses. I always get copies, they go in a nifty binder in chronological order for future reference. I learned my lesson when my last doctor retired and absconded with over ten years of my medical records. Didn’t even get a phone call.

My current doctor had me convinced that my 6.7 (.5-4.5) TSH was “slightly out of range for a 35 year old man”. Thank god I did some research and convinced her otherwise. Changed my life.

sweet-t:

Had not considered the possibility of getting copies of previous lab tests, will definitely look into that - good info, thanks! With respect to the HCG issue, that’s one of my concerns. I have kids, not interested in anymore, the aesthetic aspect isn’t that big of a deal to me, but I have heard, and read, that ignoring it has negative consequences. Not sure if I should be on HCG as a preventative or if there are numbers I need to look at. Not being sarcastic at all when I say that I need to refer to the stickies to edumacate myself some there.

With respect to the AI, my Estradiol seemed low still, in spite of the fact some members feel I was acting like a bitch, so should I start an AI prior to high Estradiol or just let it ride and see if Estradiol gets high - currently 17.2 on 130 mg of Test C once a week. My thought is to let it ride since I have no side effects currently, other than the aforementioned perception of bitchiness.

I was on 110 of Test C weekly for six weeks prior to current labs. My test was up to 515, which I think is still low, but it was taken at 3:00 PM, so, who knows really. If I can get to 750-800 without an AI, I would like that, but not sure if that is realistic or beneficial.

Thanks!

You inject once a week. Your numbers are difficult to gauge. When was the draw relative to the last injection?

E2 of 17.5 isn’t too bad if you know which assey was used. Consider this: my E2 SENSITIVE = 9, E2 SERUM = 25.5. Both drawn the SAME MINUTE. Both LabCorp tests. I now use Quest only, much more reliable IMO.

When on TRT the time of the day when blood is drawn is irrelevant. You have a poor understanding of the TRT mechanics. Not a jab, just an honest observation.

You did not gain 6 pounds of muscle. Not at that time frame, not at that T dose. Even if severely low prior to TRT. Most likely you are holding more water which on your scale registers as lean weight, but not muscle. E2 makes you hold water, take a closer look at that as explained above.

lgs:

Yeah, right as rain on several points. Answers first.

They took blood seven days after my sixth injection of 110 of Test Cyp. My understanding, rudimentary at best, is that Cyp has a seven day ester/half life, so after six weeks, I would be at max test levels based on the half life degradation of the Test Cyp.

I understand the differences between labs. Mine was Quest. I am not sure what assay was used, wasn’t aware there is more than one. But, the E2 seemed to be cool. Is that your interpretation?

With respect to my poor understanding of TRT mechanics, I think that may be accurate. My understanding is that test levels are highest in the morning. When I was originally tested, it was a 7 am test and my level was 302 and my GP declined to treat me. Three weeks later, I tested at 170 with a test taken at 5 PM by my current clinic. I was lead to believe that time of test was relevant. If it isn’t, please educate me, I am listening.

As mentioned, and I think worth mentioning again, my body fat calculations are based on a notoriously inaccurate BIA scale made by Tanita. I agree that most of the weight gain is water retention, but, and this is a big but, I am having gains in strength and size.

And, to clarify further, I have gained seven pounds. I chart my weight daily in a spread sheet with BF % and then average it for the week. Compared to the week before test, I have gained six pounds of muscle and one half pound of fat. I know this is inaccurate, but it is the best I have. I also measure with calipers, both single site and three site, and my BF is essentially the same with a seven pound weight gain.

Honestly, my goal has been to get right, to lose the fog and depression, and, for the most part, going from 170 TT to 515 TT has helped. But, I feel like I can still be better, and I want to find out how much better I can be. If that means getting to 900 TT with an AI and HCG, I will do it. The physical aspect is secondary. Trust me, I like looking better, and I am, but it pales in comparison to being alive. Before TRT, I wasn’t living, it was a train wreck.

So, I think the draw is relevant - higher in the morning, lower in the afternoon. If I am wrong, please edumacate - I am listening!

The Myth

I believe you read the stickies but not fully absorbed them.

Half life and your weekly peaks and valleys are two separate things. Cypionate praks 24-48 hours after injection. Your 515 T is the trough. Your E2 would also be lowest at the 7th day. Your weekly average T and E2 are higher. Hence it is hard to gauge your numbers with one weekly injection. Split and inject your dose 2x/week. Protocol for Injections sticky explains this. Re read.

Daily time of the draw only matters for natural guys who produce bulk of their T at night and early morning. Once on TRT this daily pulsing is gone. In your case the pulse is that giant 130mg shot of T on weekly basis. Too far from smooth natural daily production. This is why I inject EOD. Smooth ride. No highs or lows. And my labs are easy to interpret.

Quest ultra sensitive assey usually reads lower than normal assey. But if those are indicitive of your average E2 levels then you should be OK. But then again you inject once a week so we don’t know. ALSO AND AGAIN, WE NEED YOU TO POST YOUR LABS.

You don’t need to explain the vanity aspect of it to me or anyone here. I too want to look better naked. It’s normal.

I suggest more reading/research/learning here and outside this forum.

No one in this forum has ever been banned for posts in this forum that I am aware of.

Most docs do not understand the things in the stickies. If I have so many thousands of words in the stickies, why should I be repeating myself and spoon feeding fractions of that in each guys thread? I don’t get paid to do any of this and I am not part of T-Nation, I am just another guy here. If things are unpolished, that is what you get.

Normal is a statistical term that that captures most of a sample group in three standard deviations. Docs mostly think that normal means an OK state of health [very wrong]. [A few lab ranges were adjusted to be health ranges such as glucose and cholesterol.] TSH ranges from 0.5 to 5.5 in most labs. So a range of 11:1 is all healthy[wrong]. Thyroid expert doctors have tried to fixed the lab ranges but nothing gets done and docs keep their heads in the sands of lab ranges. T3 and T4 labs are hormones bound to thyroid binding globulin, T3+TBG and T4+TBG. But it is the free thyroid hormones that are active, fT3 and fT4. It is fT3 that needs to get into the cells to regulate mitochondria which produce ATP, the universal currency of energy in cells. Thyroid activity thus regulates overall metabolic rate and body temperature as the normal set point [goal]. So you can have thyroid labs that are normal in vast lab ranges where you don’t feel well and body temperatures are low, so a thermometer cuts through all of the crap and provides a measure of your metabolic rate; and how much fT3 is getting inside your cells. fT3 lab levels can be great, but rT3 can block fT3 at the T3 receptors in you cell walls then you have functional hypothyroidism with symptoms. If T, FT and E2 levels are good, one can still have weight problems, lower libido, brain fog and many of the symptoms of hypogonadism, because these two conditions share many symptoms. And to make matters worse, we see many guys here with both issues. Some guys have really bad thyroid issues and their doctors see the lab results in range and then pronounce that there thyroid if fine. Perhaps many can manage to function with such thyroid problems if their testosterone and estrogen levels are good. But we do seem to see such a strong association of testosterone and thyroid problems that one can easily be thinking that one might be causing the other. But when we see that someone has not been using iodized salt for a long time, it is easy to conclude that low T levels did not lead to their avoidance of iodized salt, so the reverse has merit. And we have seen some younger guys with pronounced thyroid problems go on Rx thyroid meds and their LH/FSH and T levels normalized. So there is a thyroid link to secondary hypogonadism. So we have these societal problems with education about iodine, lab ranges that mislead doctors and doctors who are mostly lack deductive reasoning skills and critical thinking. But another layer of problems exist when doctors take action on thyroid lab numbers; I have not seen a single report here from a guy who has had his doctor ask about iodine. The result is that doctors can put people on a life time of Rx thyroid medication when there is a simple iodine deficiency.

In your case, your thyroid levels might be optimal. But you need to look to know.

Most are faced with doctors who are ignorant of many things and don’t really care. The advice here, that many accept, is that they need to stop been passive and start managing some aspects of their own health care. Many come here with horror stories about their heath care. If your experiences are perfect, why are you needing anything? Most guys who find this forum are here because they were not getting proper medical care. Many who are here who start to understand the broader issues cannot get their doctors to do the right thing or cannot find a doctor who is not an idiot. We see that endo’s and uro’s can be really idiotic and when we see involvement with those specialists of incompetence, we suggest that guys read the finding a TRT doc sticky. And when guys are caught up in a state run health system, things are often an order of magnitude worse.

I used to go through all of the basics and explanations with every new guys thread, and took on many cases with intense PM traffic or emails. As you can guess, after a few years that was a burn out. So I started writing stickies so I could point guys written material. When I find someone who is new here, they need to be directed to the stickies. Some individuals seem to have attention issues and need to be reminded to respond to requests to read the materials and to respond to specific questions that are part of what gets done here that is diagnostics [problem solving].

In your case, your symptoms and decent T and E2 labs could be explained by low thyroid function. From that, one needs waking and mid-afternoon body temperatures, history of long time consumption/non-consumption of iodized salt or vitamins listing iodine and labs. Optimal thyroid levels are near TSH=1.0 and fT3 and fT4 that are mid range or a bit higher. Sometimes we have guys that have these optimal levels or higher fT3 with low body temperatures; enough fT3 in the blood but not the cells. In those cases we look to rT3 that blocks fT3 at the T3 receptors and ask about the factors that lead to elevated rT3; stress, illnesses, inflammation, over training, extreme diets/starvation etc.

What goes on here is way more comprehensive than all but a small segment of doctors. When I and many others see a guy reporting that his doctor state that something is normal, our bullshit alarms go off.

I can go on an on, the above is thyroid centric but the theme repeats with many other issues. You also should be aware that the high TSH levels from iodine deficiency can lead to enlarges thyroid glands then lumps that product thyroid hormones outside of the TSH control loop and these can lead to cancer. So iodine deficiency leads to hypothyroidism that can progress to hyperthyroidism [high TSH] and some of those cases lead to cancer.

Related: We know from histories of guys here that low thyroid function is strongly associated with low absorption of transdermal T [creams/gels]. So poor absorption of transdermal T is a symptom of hypothyroidism and we act on that. So there may be a progression of iodine deficiency to low T to inability to respond to transdermal T and again, totally off the radar of the broad medical community.

[I have not stated anything here that is not in the stickies.]

I have read a stack of books on male hormone centric books, sexuality, thyroid books and adrenal fatigue as well as other medical/heath/nutrient reading. I have studies drug interactions and done a huge amount of research driven by health conditions, lab results, and symptoms presented in individual case threads. [I also understand female hormone issues, but few threads here on that.]

If I speak with authority, it is from understanding and conviction. I also get directive because I can’t take the time to spoon feed and micromanage every case that I get involved with.

1 Like

Lgs,

Do you remember the lab ranges for that sensitive lab Corp test? We’re they like 7-42 or similar?

LabCorp serum 7-42

LabCorp sensitive 3-70

The once weekly injection is going to be biggest hurdle to nailing down your TRT. If you have to stick to that schedule, you probably need to get testing done at your peak, not just your trough. You may find that the numbers for both look ok, in which case weekly injections might work just fine for you. Or you may find that there are big swing in T and E2. Most threads I’ve read on multiple boards, people do better with 2x or 3x weekly injections. Much more stable levels.

If it were me, I would inject at least 2x weekly and aim for the 20s (labcorp) for both Free T and E2. If you’re not using labcorp, aim close to the top of the range for Free T. If you can hit that, any additional health improvements are likely to come from somewhere else. Working with just total T doesn’t tell the whole story.

Then you look at adrenals, thyroid, DHEA-s, etc. In a perfect world these would come first, but T replacement is the easiest way to get to feeling somewhat normal. It gives you the bandwidth to look at things more complex and difficult to sort than T and E2…if you can get to the point you know T and E are not the issue, which is what the previous paragraph aims to do.

I appreciate all of the feedback, and of course, beginning to realize this is a lot more complex than I originally thought. I see my TRT doc on Monday and will get a copy of my original labs then, not sure if she tested for thyroid function or not, but will get the results and post them. For what it’s worth, I did buy a thermometer today and will be taking my temps starting tomorrow morning. Will post those when appropriate after re-reading the thyroid sticky.

I’m uploading the two pages of my labs taken before my seventh shot of Test Cyp. My first six were 110 MG weekly and we bumped to 130 MG weekly. She also has me taking Grape Seed extract to help with aromatization issues, I think to delay having to take an AI if possible. I have no side effects to date with the exception of water retention. I have gained weight, but also some size, and have had good strength gains in the gym, so I’m not sure how much of it is water and how much is muscle. I use a Tanita scale for checking bodyfat but realize its limitations.

I haven’t had major issues with crashing before my next shot so I’m not sure if I need to go to E3D but realize I need to keep an eye on this. Also, I don’t think the 130 MG weekly is going to get me where I want to be and know that I will have to revisit the protocol if we bump again after the next round of tests. They don’ allow self injection, at least not yet for me, and I realize I may have to shop doctors if and or when this issue comes up.

Again, any feedback or advice is appreciated. I will be revisiting the stickies to try to digest the information a little better.

It appears I will have to upload the images in two replies so look above, or below, for the second image.

Regards.

Second image, I hope.


It appears the images did not post. I have changed them to gif’s and will retry. If they don’t post, any suggestions would be appreciated.

I am editing now, glad to see they posted. Please note that I misspoke, these are from Enzo, not Quest.


It seems the GIF format works, this is page 2.

Regards.

Those numbers are not bad considering that’s your trough. Peak is probably double that or so. You should test at peak also. You might be ok with one a week shot but I am sure you would do better with 2x.

Why can’t you home inject? NY state fucking you? God I hate that awful state that regulates every fucking thing. I am glad I moved from there years ago.

Nice cholesterol numbers btw.

You are probably already aware of this but you are currently at risk of becoming diabetic. Even though the numbers don’t yet qualify as pre-diabetes they’re right there. Making some small dietary improvements and incorporating a simple exercise routine will make a world of difference.

While your hemoglobin and hematocrit numbers are normal they could use improving and TRT should help change this.

As far as TSH numbers go this is what I’ve learned about it:
< 2 ok

2-4 Monitor every 6 months. Worth checking for anti-thyroid antibodies and assessing if there is an iodine or selenium deficiency. Personally I wouldn’t bother with iodine supplementing other than maybe a multivit unless you can identify that it is indeed a huge lack. It will screw up gut flora for months and drive TSH numbers up which I think indicates some form of thyroid toxicity. In reality there’s really little to be concerned about unless there are high levels of APO in which case may suggest thyroid replacement.
4.5 this is where treatment becomes highly suggested but it’s at least advisable to see this level repeated before replacement. Doctors may actually feel there is a need to do something here but likely won’t help unless pressed if you’re lower than 10
10 clearly Subclinical hypothyroid and should be treated.

As far as body temps go I haven’t seen any real evidence that it’s a reliable indicator. This seems to be a naturopathic indicator of which I have no faith in.

Yep, pretty okay with the numbers, would like to run at 800 but realize, or am beginning to realize, the difficulties with peak and trough.

I think I am moving to twice a week, just need to move my provider that way.

My brother in law is also on TRT through a plastic surgeon, and he is pimping me for info. They just jack him up and when he gets rage and itchy nipples, he lays off it for a while. I’m more interested in getting it dialed in and being in the sweet spot.

I think I can self inject, I just need to find a doc that will allow it. I want to get it dialed in with labs before I do that.

The cholesterol is a function of the gym, appreciate your appreciation of the numbers.

With respect to diabetes, yeah, that’s a huge concern. My father is type 2, but he is morbidly obese. I know my sugar numbers are pre-diabetic, I have been at 110 and 106 before. I’m better when I am in the gym, and with TRT I tend to get to the gym more often. I also think with TRT I have better insulin uptake, not really sure about this, but my A1C went down.

Still trying to figure it all out. I suspect you saw the A1C number and not the sugar number of 94. Both are coming down on TRT.

Regards

TRT should give you better glucose numbers. Pre TRT I was at 90, now I regularly test between 78-85.