Can Someone Clarify Why Ultrasensitive E2 Test Shouldn't Be Used?

I’m speculating. But I am thinking those numbers would correlate with slowly gaining weight over time and liver aging, slowing estrogen disposal. I don’t know though.

Why would age alone increase it? Maybe the natural decline of muscle plus then inherent fat gain that comes with low T aging.

Shouldn’t be a problem I don’t think. I’ll let you know in 30 years.

Ok guys. Here are my latest results. This is on 100mg test weekly, (50mg e3d) and was done a few hours before my next shot:

Testosterone,Total,LC/MS/MS 860 ng/dL 250-1100
Testosterone,Free 178.9 pg/mL 35.0-155.0
Estradiol 33 pg/mL < or = 39 pg/mL
Sex Hormone Binding Globulin 23 nmol/L 10-50
Estradiol,Ultrasensitive 27 pg/mL < Or = 29

So numbers look fairly good in my opinion, but I see my SHBG went down from 27 (however, I was on once weekly shot of 100mg test with that reading)

I’m not feeling a great sex drive. I’d like to either try to add some DHEA and raise e2 OR try low dose arimidex to lower e2 just a tad.

I’m not sure whether or not my e2 is low or high due to differing theories of where e2 should be (ratio vs. e2 =22)

My only true issues are super sore shoulders, almost like the tendons are stretched out (indicative of low e2) and I have zero libido. Good nighttime and morning erections. With my girlfriend, I need to take sildenafil and really don’t feel sex drive.

If I were to try the arimidex route and try to lower e2, what dose? The standard 1mg per 100mg test may be too much I’m guessing as I’d only need to lower e2 a few points.

OR, as another member posted, I could lower test dosage and see if e2 falls some more.

Help! Ideas? It’s been 20 years since feeling libido!

KSMAN?

your free testosterone (the one that matters) is a little high. You have some room to lower your dose, if that’s what you want to do.

I had similar numbers on 100mg a week. My e2 on non sensitive was 32. Had some nipple itchiness.

Dropped to 80 a week and my e2 went to 29… Now im at 90 a week my e2 is 30. No negative symptoms.

You need to realize libido doesn’t happen overnight for everyone, you must keep all your levels in their ranges for several months, it can take up to 1 year for the full effects of libido to occur. I would reduce the test dosage before ever adding an AI, AI can ruin your TRT experience if you take it and don’t really need it.

You want to lower your E2, lower the dosage. If you took even .5mg AI you would regret it for the next 6 weeks and so would your girlfriend.

I recommend 45mg twice weekly.

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Appreciate the responses and tend to agree.

I’ve been on trt for over a year with different protocols.

I do notice a clearer head on the 50mg e3d protocol. Like I can think better and talk better if that makes sense. Also a little better sleep and actually have (or at least remember) dreams.

The only reason I mention adding dhea to up e2 is due to Nelson Virgils ratio theory. By that theory, my test looks good but e2 should be much higher. I’d think increasing it with dhea would be less forgiving than crashing e2 with ai.

Thinking of dropping test to 40 or 45mg e3d. How long would it take until I see some positive reaction? I’d guess on that protocol my e2 would be close to that 22 range.

It doesn’t matter if you have good testosterone levels, if your sleep is poor forget about libido. Once you start sleeping better and hitting REM sleep, months later you’ll notice you have libido and it will gradually increase up until a year.

Don’t short change yourself, -10mg could bring E2 in a range that’s good for you.

You could even drop to 40, just to see if the lowered dose DOES lower your e2 into the sweet spot.

If you have good results from a lower dose, you know your e2 is too high. The lower dose allowed your e2 to lower into a good level.

So I think I’ll try just lowering the dose awhile.

How long until I should feel some difference, if any, before making another change?

I would give it a few weeks before you make another change.

Alternatively, if I think my e2 is too high, ill drop the dose, and I can tell the difference in just that injection over the next few days.

Lowering to 40mg e3d.

I’ll check back with this thread in a few weeks or sooner
If I have a breakthrough in symptoms in a positive way.

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So I tried 40mg e3d and almost immediately felt sluggish. I could feel that it was too low a dose. Just felt weak, apathetic almost. SO, I think I need to be at 50mg e3d, where I feel a bit more strong and clear headed and introduce arimidex, as libido is still not around.

I am now two doses in on Arimidex. .25mg e3d. I haven’t felt much, but actually have felt a tinge of sexual aggression around my gf. I don’t want to speak too quickly.

Now, granted my e2 on the 50mg e3d protocol is 27pg/ml on the sensitive test, I don’t think I need to go much lower. I’d like to get to 20-22. Just trying to pinpoint if it’s e2 that’s causing low libido or something else. Trying to rule out possible causes.

Is it possible to have really no symptoms of high e2 except low sex drive? I have good wood, etc, except during sex as libido isn’t there too much.

Anyone with any advice or thoughts on how long to run the .25pg/ml arimidex dose until I should see any possible improvement? Was thinking about running it a couple weeks, and if I don’t see any increase in libido, possibly upping it to .50pg/ml e3d.

Scared to crash it though

Your E2 on 50mg twice a week was 27.

You lowered your dose to 40, AND your taking an AI?

Or did you take the AI after being on 50mg twice a week?

Either way, you need to tread lightly. arimidex and other ai’s absolutely DESTROYED my first year or so on TRT. I still have side effects from it being low for so long.

I didn’t feel libido turn on strongly until I started injecting EOD, twice weekly it was nonexistent even with solid consistent numbers.

Running 50mg e3d along with .25pg/ml arimidex e3d.

Yes. I have e2 at 27 at this testosterone protocol, but lowering dosage affected my energy way too much. So my thought it’s I need to keep the test higher (my present protocol) but rely on arimidex to lower e2.

Dying to feel a sex drive guys. It’s been like 20 years. I feel like I’m acting sometimes around my gf.

Do you get AM or PM wood?

Both. Great morning and night wood.

I can get it too with gf, but will evaporate if I attempt sex. I know that part is in my mind. Probably stage fright from worrying about losing it. Best way to describe it is that there is just a little blood flow. Not the full amount that should be occuring. So I rely on Sildenafil.

But I just don’t seem to get horny. Even during sex etc. The attraction is there but that drive/lust feeling is absent.

I’ve often wonder if it’s a norephedrine issue. I have tried cabergoline and selegiline and didn’t feel anything. I’ve had an mri but nothing showing.

physio and I were talking to a gentlemen on Pharma, that was having “deca dick”

He reported having good AM and PM wood, which SHOULD mean that your hormones are fairly balanced.

If you have strong AM and Pm woods, stop fucking with hormones. Its likely NOT hormone related.

Also remember TRT takes a little time to restore everything.

Do you take any dopamine depleting medication?

Only med I take is small dose wellbutrin. Both prior to and along w trt. I’ve been on trt well
Over a year.

Can you quit taking it?

Absolutely. But I like the energy it gives me. It’s such a small dose 100 mg I’ve taken a TRT without it prior to.