Brain Function Boosters

Nutrition
572

[quote]j2048b wrote:
gnosticjon,
Thanks for the input, about how long would it take for something to be completly out of the system? I mean as far as nootropics go, do certain ones actually stay in your system even after you’ve stopped taking them?

[/quote]

I don’t mean to be repetitious, but of course the answer is: it depends. If you look up each supplement you should be able to find its half-life. The half-life is the time it takes for the chemical to be reduced to one half its original quantity. So if you start with 100mg of whatever and its half-life is 4 hrs, then after 4 hrs you would be left with only 50 mg; after 8 hrs 25 mg and so on. The process for many substances is far more complicated than this simple summary implies but this should be enough for our purposes.

Nicergoline is rapidly metabolized in the body, while hydergine has a half-life of about 3.5/4 hours; modafinil is much larger at somewhere between 8 and 12 hours (though there may be some difference between brands, etc).

With some research and a little bit of math you should be able to craft a custom nootropic blend granting mental powers just shy of Stephen King’s “Carrie.”

573

gnosticjon:
HAHA AWESME!! OHH to act as “carrie” and throw shit with my mind and stuff!! awesome!!\

I will video tape it if my mind does those things,from my nootropics usage, then drop and pray and probably shit all over myself!

575

[quote]roweski wrote:
gnosticjon wrote:
Merlin7777 wrote:
Mixing vinpo and hydergine is neither necessary nor a good idea. Vinpo is one of the few substances specifically advised against mixing with hydergine.

Interesting. Whats the reasoning behind this?
Because of the serotonin and dopamine release it stimulates?

-Rowesk[/quote]

My understanding is that both hydergine and vinpocetine dilate blood vessels, particularly targeting those in the brain. The thinking is that taking both simultaneously could dangerously lower one’s blood pressure or lead to other untoward effects.

My first thought was that by increasing blood flow to the brain, the combined effect of the two would result in something like that guy in “Scanners” and one’s head would explode, but of course, that is not the case.

I cannot definitively confirm or refute your theory, Rowesk, as I simply don’t know. You may be on to an interesting hypothesis worth exploring. So, although I incline to the former answer as being the reason for the cautionary statements, it may be I simply don’t know enough to properly address your question. Let me know what you find out.

576

[quote]j2048b wrote:

gnosticjon:
HAHA AWESME!! OHH to act as “carrie” and throw shit with my mind and stuff!! awesome!!\

I will video tape it if my mind does those things,from my nootropics usage, then drop and pray and probably shit all over myself!

[/quote]

If you start to throw shit with your mind let me know what your ‘stack’ is as I would like to give it a shot.

577

[quote]gnosticjon wrote:
j2048b wrote:

gnosticjon:
HAHA AWESME!! OHH to act as “carrie” and throw shit with my mind and stuff!! awesome!!\

I will video tape it if my mind does those things,from my nootropics usage, then drop and pray and probably shit all over myself!

If you start to throw shit with your mind let me know what your ‘stack’ is as I would like to give it a shot.[/quote]

Some combo or OD is causing me to feel pressure in my neck and sinuses and my left nostril is full of dried blood every morning. Or it could be the sand storms we had the past three days.

I am going to check all the contents and make sure that I am not taking two conflicting substances.

580

hey guys i just got my braine octane and was wondering if it would be a better idea to start with like 4 tablets a day as opposed to 4 (2x’s a day?)

Just wondering due to me never using nootropics at all?

What should i be looking to gain from the brain octane?

582

Oh, that certainly wasn’t MY stack!
Mines bigger! Ha, not really.

Right now I am only taking vinpo, oxy, glutamine, and Power Drive. That list was meant more as a summary for this thread. I am trying to keep it updated.

Here is the new version:

Vinpo
Oxiracetam / Aniracetam
Brain Octane (which has choline)
Adrafinil / Moda (If you can find them)
Huperzine
Hydergine (Don’t use when taking vinpo / maybe use with vinpo, but slowly at first and in small amounts)
Glutamine
GABA (?)

Power Drive (Not so much.)

Note: This list does not specify a “Stack”. Just components that can make up a stack. By no means should you take every single component.

What else should I add?

584

“Glancing at the stack, its size stands out. While there is not necessarily anything wrong with taking several things at once, unless one tests each individually over the course of several weeks one cannot tell which chemicals are doing what. You might be better served by picking one supplement, trying it for a few weeks, and then cease it for a time while you try another in isolation to all others”.

  • This is some REALLY GOOD advice for anyone who is into self-experimentation with these substances. For me, I am just now completely comfortable with Adrafinil. After 2 months or so, I now know what this substance can do for me in a short or longer period of time. I have tried many different dosages, all at once, spaced out, etc.

I have tried periods of time off to see what happens to me, or if there is any sort of withdrawl. I have tried taking a huge dose on one day and then counted the days that I get an after effect, without further supplementation. Only now, I can say that I have tried almost every scenario (within reason), that could apply to my life and this drug.

So for now, the Adrafinil is in the cupboard, only to be used for special outings, or sleep depravation (on the road for work, etc.). I would like to use 300-600mg per day, every day instead of coffee. But for now I am going to stay off so that I can start some new experimentation with Racetams.

Just like the Adrafinil experiments, I would like to have my system as clear of other substances as possible. I intend to see how just 1 racetam effects me, without having to question if the effects come from another substance, or combination.

Question for everyone. What seems to be the consensus on a good SINGLE racetam to start with? I have read on this thread that a combo seems to work for some, others are getting a bit drowsy from one and not the other, etc. I am primarily looking for one that would aid in quickening the thought process, and possibly a small improvment for memory.

My job requires quick decision making (often times 1-2 million dollar decisions in the course of a 15 minute window). My job also requires me to sometimes recite US food law and regulation from memory (I always need a solid working knowlege of it). Anything that could help give me an edge with this type of job, would be greatly appreciated. I would like to stick with Racetams for now (as I am intregued with how they might work with me), but I am open to other suggestions.

As always, thanks for everyone’s imput and stories. This has been a great thread!

Peace,

585

row,

common sense? come on now, someones common sense to something is totally different than someonelses!

i only asked du to the fact the bottle says 1 serving is 8 pills!!!

and it is 2000mg of piracetam with 8 pills, i thought that to be a bit much

i will start with 2 pills, and let everyone know if it has an effect or not?

586

[quote]roweski wrote:
Jon,
After much wikipedia-ing i have found that [sic] “Hydergine stimulates the production of dopamine and seratonin, whilst blocking alpha-andrenoreceptors.”

Meaning that this modulation of the synaptic nuero-system is probably the primary way it acheives any nootropic properties. I’m not saying that it’s dialatory effects don’t contribute, but rather that the evidence given is more likely to produce a noticable effect.

As for hydergine being somewhat-localized brain vasodialator; we know ergoloids pass the b/b barier, and it is, itself, a vasodilator. But whether it actually targets the blood vessels in the brain is unclear. I’d say the majority of its nootropic effects stemmed from the hormone stimulation rather than the increase of bloodflow.
Meaning that both hydergine and vinpo should be fairly suitable, possibly even synergistic, with seratonin and dopamine flowing around the brain with less resistance.

I would lower the doses of both to start out with, increasing the hydergine dose first then adding more vinpo SLOWLY to test tolerance.

-Rowesk[/quote]

Rowesk:
Thanks for the information. Let me reiterate that I did not nor do I now dismiss your interpretation of hydergine’s effects. I agree that I may overestimate the importance of the vasodilatory effects of hydergine. By way of explanation (excuse?) I would say that looking over many of the studies of hydergine, I note that they often studied the vasodilating effects rather than others. I concluded that that particular aspect must be paramount. Also, I reasoned that vinpo also acts as a vasodilator (among other things) and that this must be the reason why some warned against mixing the two–especially as hydergine sometimes carried the warning against mixing with other vasodilators. At any rate, I may be wrong in my thinking and thank you for the added data and differing perspective.

Looking over (again) some of the available resources about hydergine I am struck by the introductory choruses on pubmed to almost every hydergine study: “its mechanism of action is still not clear.” Studies conducted recently do seem to look at some of the other avenues of action that may account for hydergine’s effects, but they are still inconclusive.

Taken by itself, or responsibly taken with other substances according to its guidelines, hydergine is generally considered safe. I find it effective and rather free from sides. I am not sure that I will mix it with vinpo yet, but will wait for your report.

Regarding your experiment, if we don’t hear from you for a few days, should we send an ambulance by?

587

[quote]mc_neumann wrote:
gnosticjon wrote:
j2048b wrote:

gnosticjon:
HAHA AWESME!! OHH to act as “carrie” and throw shit with my mind and stuff!! awesome!!\

I will video tape it if my mind does those things,from my nootropics usage, then drop and pray and probably shit all over myself!

If you start to throw shit with your mind let me know what your ‘stack’ is as I would like to give it a shot.

Some combo or OD is causing me to feel pressure in my neck and sinuses and my left nostril is full of dried blood every morning. Or it could be the sand storms we had the past three days.

I am going to check all the contents and make sure that I am not taking two conflicting substances.[/quote]

Tough break, but it sounds like you have a good plan to sort it out. Let us know how it goes. Good luck.

588

Just some results after 2 weeks of l-tyrosine and DMAE supplementation. Basically 2 out of the 3 ingredients from Power Drive.

I’ve been taking the l-tyrosine first thing in the morning with a tribulus tablet. I seem to be in a good mood all day long. I’m not sure I’m any mroe focused, but feeling good. I know there are some studies out there saying l-tyrosine help with depression, and not that I’m depressed, but it sure seems to elevate mood. I’d recommend this supplement to anyone feeling down or not.

I’ve been taking the DMAE with 2 ZMA capsules before bed. Wicked dreams thanks to the ZMA, but I seem to be having deeper sleep. I usually take a nap after work every other day that lasts around 2 hours and then naturally waking up. I find that I’m sleeping 4 hours and could sleep more.

The main reason I’m trying these supps is to help combat fatigue and improve sleep for recovery purposes as I am training harder than usual for 12 weeks. I’m also taking weekends off, so am on a 5 on 2 day off schedule with these.

In short, the l-tyrosine has helped mood, thus aiding workouts, whereas the DMAE has improved deep sleep quality. I’m going to have to try some of the others on this thread, but am starting off light and slow instead of starting off with the ultimate brain tonic.

589

Huperzine-
Has anyone had any sides with the Hup-a.
I have just started and I seem to get a few aches akin to a flu (I can’t believe I used the word akin). Presently taking Aniracetam and Vinpocetene. I believe in them as I do concentrate better and I don’t get tired or distracted as much. Man I wish I had these back in school.

592

So I’m back with more diet-related (natural, if you will) methods of enhancing brain function. I came across this on Wikipedia for “ketone” and thought it would apply here.

I posted some stuff about intermittent fasting and exercise a while back in relation to enhancing brain function. I figure these three methods are free and likely have a greater long-term effect that would drugs. Plus diet and exercise have been shown to change neural plasticity and morphology to enhance brain function, and I’m not sure if many drugs can claim that.

I’d be curious to see a comparison of diet, exercise, and supplement effectiveness for brain function boosting, but at the same time I’d imagine they all work differently (diet and exercise are different) in their boosting methods. I’m sure a combination of everything would be the best option.