Brain Function Boosters

Nutrition
441

[quote]bushidobadboy wrote:
I’m currently using idebenone (60mg /day I believe).

HOWEVER, something has been missing in my cognition/awareness recently, and I was searching mentally as to what it might be.

Your comment about huperzine is spot on. That is the ingredient that I ran out of last year and so this must be the vital component of my missing mental sharpness.

Thank you! I shall get on and order some NOW.

Bushy[/quote]

          Agreed about the Huperzine Bushy. I recently saw a cheaper end brain supp with just a few ingredients, and the Huperzine was one, and it was quite effective, so I will be adding it to this semesters brain "cocktail".

        I'm going to give the "brain octane" a go from superiornutraceuticals.com, and add the Huperzine/Vinpo/ to the mix, as well as at some point trying a bit of the centrophenoxine to "clean house" too. Should be a solid mix I think. I will probably get some Adra later when the fundage is up a little more.

                 Tonebone
442

Hello All,

This is day #2 for me on the Adrafinil. This time I ingested 1 pill (same as Thursday), but on an empty stomach followed by 8oz of water. In about 20 mins I had the usual breakfast (minus the coffee again), followed by about 12oz of good orange juice.

Things were a bit different than yesterday. For one, the Adrafinil seemed to kick in more quickly. The effects seemed to come on around the 45 minute mark. I was also ready for it this time so I could almost feel it “rolling on” if that makes any sense. Slow waves of energy until It seemed that I hit a peak.

It has now been 8 1/2 hours, and once again there is no feeling of tapering off. I feel like I could go for days, or just lie down and take a nap if I wanted. This chemical seems very strange in this sense.

Speaking of sleep, I slept like a puppy last night. I did not have any issues at all falling asleep. It seems like this stuff is powerful and and gives almost limitless energy when I need it, but mellow when I don’t. It is almost like I am able to mentally turn off the light switch when I feel like a bit of down time. This is really, truely, amazing stuff.

There are a few points and concerns that I would like to touch on.

  1. Has anyone heard of people developing a tolerance to this medication? The concensus seems to be that cycling off for periods of time would be good for the LIVER, but I have not heard any evidence of developing a tolerance. Does anyone have any info about this, personal or otherwise?

  2. Has anyone been able to find studies or hard data as to how hard this might be on the liver? Once again, it seems that prudence dictates that this is cycled off occasionally. I am mainly curious how long I could go before stopping. When I do stop, I would hope that it would not have to be for too long.

I’m thinking that weekends off would be a good idea. But I could also get a lot accomplished at home with this as well. I will try to dig up some more info for this if it can be found.

The reason that I have the above questions, is that I would like to replace coffee with this (after more experimentation of course). As of yet, it is not a scheduled drug in the USA, and it is also relatively cheap. If I could stick with one pill a day as an effective dose (assuming I don’t build up a tolerance), this would be a reasonably priced alternative.

I certainly wouldn’t mind paying a bit extra per month, for better stimulation, word and conversation flow, and no side effects (as of yet anyway). This is something I will need to think about more.

A couple of points and observations: This has seemed to take the edge off the occasional depression I get. More long term study will be required to see if this has a lasting affect. Another point is that it seems to make social interaction all that much easier (for me anyway). I don’t have to stop and collect words before spitting them out. They just flow naturally. I will need to watch what I’m saying in public for a while so something dumb or insulting doesn’t fly out. This hasn’t happened to me yet, but I think that the potential could be there.

As far as the leftover fuzziness from the prior dope smoking is concerned, this seems to slice right through the fog. Something to think about for the prior smokers here. Tone, did you notice this with the Moda at all?

Anyway I think that I will walk away from the keyboard for a bit. I’ve just noticed that I’ve written quite a bit here. I hope this wasn’t too much. See ya next time.

Peace,

444

[quote]D3HT09 wrote:
Hello All,

This is day #2 for me on the Adrafinil. This time I ingested 1 pill (same as Thursday), but on an empty stomach followed by 8oz of water. In about 20 mins I had the usual breakfast (minus the coffee again), followed by about 12oz of good orange juice.

Things were a bit different than yesterday. For one, the Adrafinil seemed to kick in more quickly. The effects seemed to come on around the 45 minute mark. I was also ready for it this time so I could almost feel it “rolling on” if that makes any sense. Slow waves of energy until It seemed that I hit a peak.

It has now been 8 1/2 hours, and once again there is no feeling of tapering off. I feel like I could go for days, or just lie down and take a nap if I wanted. This chemical seems very strange in this sense.

Speaking of sleep, I slept like a puppy last night. I did not have any issues at all falling asleep. It seems like this stuff is powerful and and gives almost limitless energy when I need it, but mellow when I don’t. It is almost like I am able to mentally turn off the light switch when I feel like a bit of down time. This is really, truely, amazing stuff.

There are a few points and concerns that I would like to touch on.

  1. Has anyone heard of people developing a tolerance to this medication? The concensus seems to be that cycling off for periods of time would be good for the LIVER, but I have not heard any evidence of developing a tolerance. Does anyone have any info about this, personal or otherwise?

  2. Has anyone been able to find studies or hard data as to how hard this might be on the liver? Once again, it seems that prudence dictates that this is cycled off occasionally. I am mainly curious how long I could go before stopping. When I do stop, I would hope that it would not have to be for too long.

I’m thinking that weekends off would be a good idea. But I could also get a lot accomplished at home with this as well. I will try to dig up some more info for this if it can be found.

The reason that I have the above questions, is that I would like to replace coffee with this (after more experimentation of course). As of yet, it is not a scheduled drug in the USA, and it is also relatively cheap. If I could stick with one pill a day as an effective dose (assuming I don’t build up a tolerance), this would be a reasonably priced alternative.

I certainly wouldn’t mind paying a bit extra per month, for better stimulation, word and conversation flow, and no side effects (as of yet anyway). This is something I will need to think about more.

A couple of points and observations: This has seemed to take the edge off the occasional depression I get. More long term study will be required to see if this has a lasting affect. Another point is that it seems to make social interaction all that much easier (for me anyway). I don’t have to stop and collect words before spitting them out. They just flow naturally. I will need to watch what I’m saying in public for a while so something dumb or insulting doesn’t fly out. This hasn’t happened to me yet, but I think that the potential could be there.

As far as the leftover fuzziness from the prior dope smoking is concerned, this seems to slice right through the fog. Something to think about for the prior smokers here. Tone, did you notice this with the Moda at all?

Anyway I think that I will walk away from the keyboard for a bit. I’ve just noticed that I’ve written quite a bit here. I hope this wasn’t too much. See ya next time.

Peace,
[/quote]

          Hey buddy,

Yes if one were to go back to the week or so that I was running the Moda, you will find exactly the same thing. It’s just as you said, and hearing this makes the Adra VERY cozy looking for US residents to purchase vs. the scheduled Moda. Not to mention the shit is pennies to the dollar for comparable amounts between the two. I’m very impressed with the accounts you’ve logged down, and again I can verify every last one of the things you mentioned as they all were experienced my myself almost verbatim as you have said they happened to you. That’s it, I’m going to purchase some for my nootropic chemistry set for the upcoming semester. Look out Physiology, cause here I come.

                 ToneBone
445

[quote]bushidobadboy wrote:
Nice log D3HT09!

Yes moda and adra will IMO become increasingly popular once the public cottons onto the idea that stims are nothing like this stuff, and that as you point out, you can have energy when you need it, but can also chill when required too.

Now the reason you notice a quicker response is because (I believe) the adra builds up in your system over time, so the threshold at which you notice the effects will come on earlier, due to residual amounts of the drug in your system.

Unfortunately, you will almost certainly develop some form of tolerance, since that is what the body does. Even if receptor changes do not occur, enzymatic profile changes will likely happen, meaning that you metabolise and excrete the drug more efficiently than before.

Now that you have experienced the benefits of this lovely nootropic, you may want to consider others, since they can give similar benefits, during those periods where you are ‘off’ the adra to allow proper restoration of liver function and drug sensitivity.

I’m glad you are enjoying the adra. Chemistry can be a wonderful thing, when used correctly.

Bushy[/quote]

        Great points and advice as per the norm for you my friend. Thanks from all of us for helping me start this great thread, and for helping us all keep it going!!

        It's going to be a great year for us, once you get through your situation, and yes it will be a bitch, but nevertheless, once you do get through it, then I know something good and very positive is going to happen to you.

          I like to think that Karma exists my friend, and you certainly have a boatload of positive Karma coming your way for all the great help and friendly advice you have given out so freely to everyone on this site.

                  Cheers!

                 ToneBone
447

[quote]bushidobadboy wrote:
Thanks my friend. Hopefully Karma will look favourably on me, however she did shit down a ton of bad luck on me regarding the circumstances of my arrest.

However I am looking at the positive aspects; I’ve never been arrested before ans it was certianly a learning experience.

Also, the cessation of illegal activities has allowed me to destress (paradoxically) and realise tha it just wasn’t worth it.

Barring the occassional breaking of a speed limit here and there, I fully intend to live a law abiding life.

Bushy[/quote]

       But you see that's where the beauty lies my man, since shitting down a ton of bricks on you, she now OWES YOU A TON o' POSITIVE ENERGY!!

You have the right attitude and have centered yourself on priorities and taking care of #1, namely yourself. As you said, even with what is happening right now, being stressful in itself, you’ve unloaded a great deal of self induced stress which had come about from your outporing of help to so many. Now it’s time to take care of Bushy, and let us little birds fly on our own so to speak. You’ve got us all out of the nest, and now we’ll all be happy to see you get to “relax” and take care of your wonderful brain as you continue to destress and set yourself on course once more.

          Cheers again, and take care mate!

             your good buddy,

                  ToneBone
448

Howdy Everyone,

Today is day #3 of the experiment. I took the weekend off from this lovely medication. Until I can find more info on how to cycle this stuff, I will take weekends off. When I run out, I will take that time to be off, until the next delivery arrives (approx 1 month). Anyway, this weekend was interesting. I had after effects from the Adrafinil.

Even without taking a dose Saturday or Sunday, I could still feel an energized effect. This definatley was not as strong as taking a pill, but the effects were pleasant. It was nice to have a bit of extra energy to get some stuff done around the house. I did not experience a letdown or crash of any sort. Once again, this is some pretty cool stuff.

Today I ingested 1 pill with 8oz of Orange juice (crappy concentrated variety). about 10 minutes later I had the usual breakfast (still without coffee)followed by 12oz of ice water. The effects of the pill came on at the 1 1/2 hour mark. This lends credibility to Bushy’s theory about a build up of chemical in the body. My weekend after effects also back up this theory.

I have noticed slightly less of an effect today. Don’t get me wrong, this still works very well (especially helping with work that I may not want to do), but the effect is not quite as pronounced. I may bump up to 2 pills spaced 5 hours apart for tomorrow. It seems that some have a great reaction to this amount, others find it too “speedy”. At 240lbs (weighed this morning after a dump), I don’t think that this amount will be too overwhelming. For the sake of science, I think I will have to try it.

Also for the sake of science, I am curious about bioavailability of this chemical and grapefruit juice. I have always liked grapefruit juice, and am curious if it will increase the effect of the Adrafinil. Something I may try later in the week (or possibly tomorrow instead of taking 2 pills). Or does the grapefruit juice thing not work for this chemical? I guess there is one good way to find out:)

I had posted earlier that I may want to try the Modafinil at a later point to compare and contrast these 2 substances. At this point, I think that the only way that I will do this is if I can get a prescription for it. My reasons for this are price (almost 3 times or more of the cost for Adrafinil), legal issues (I think it is schedule IV, same as AAS, but I’m not completely sure), and availability of Provigil. It seems from reading this thread and others, that there is a difference between generic Moda and Provigil. I don’t see the point in taking the risk for a generic Moda that is too expensive and may not be as good.

I may be able to fenagle a prescription for the Moda here in the states (assuming my insurance covers it, otherwise it will be too expensive). I have some doctor’s appointments later this month, and may be able to push for something like this for fatigue and improvement from depressive moments. Although I am leery of telling my doc that I tried some of this Adrafinil. It works so well for multiple issues, that I should probably swallow my nervousness and just let her know. I will cross that bridge at the end of the month.

Anyway, it has now been 5 1/2 hours since I popped the pill, and I still feel fine. I have to question if this lower effect today has to do with tolerance, or lack of drug built up in my system. the lower effect is not that much lower, it just seems more familiar. Maybe I am just becoming accustomed to this drug faster than I thought. I guess I will see tomorrow. Anyway, see you guys later, thanks for listening and providing responses and theories.

Peace,

449

[quote]D3HT09 wrote:
Howdy Everyone,

Today is day #3 of the experiment. I took the weekend off from this lovely medication. Until I can find more info on how to cycle this stuff, I will take weekends off. When I run out, I will take that time to be off, until the next delivery arrives (approx 1 month). Anyway, this weekend was interesting. I had after effects from the Adrafinil.

Even without taking a dose Saturday or Sunday, I could still feel an energized effect. This definatley was not as strong as taking a pill, but the effects were pleasant. It was nice to have a bit of extra energy to get some stuff done around the house. I did not experience a letdown or crash of any sort. Once again, this is some pretty cool stuff.

Today I ingested 1 pill with 8oz of Orange juice (crappy concentrated variety). about 10 minutes later I had the usual breakfast (still without coffee)followed by 12oz of ice water. The effects of the pill came on at the 1 1/2 hour mark. This lends credibility to Bushy’s theory about a build up of chemical in the body. My weekend after effects also back up this theory.

I have noticed slightly less of an effect today. Don’t get me wrong, this still works very well (especially helping with work that I may not want to do), but the effect is not quite as pronounced. I may bump up to 2 pills spaced 5 hours apart for tomorrow. It seems that some have a great reaction to this amount, others find it too “speedy”. At 240lbs (weighed this morning after a dump), I don’t think that this amount will be too overwhelming. For the sake of science, I think I will have to try it.

Also for the sake of science, I am curious about bioavailability of this chemical and grapefruit juice. I have always liked grapefruit juice, and am curious if it will increase the effect of the Adrafinil. Something I may try later in the week (or possibly tomorrow instead of taking 2 pills). Or does the grapefruit juice thing not work for this chemical? I guess there is one good way to find out:)

I had posted earlier that I may want to try the Modafinil at a later point to compare and contrast these 2 substances. At this point, I think that the only way that I will do this is if I can get a prescription for it. My reasons for this are price (almost 3 times or more of the cost for Adrafinil), legal issues (I think it is schedule IV, same as AAS, but I’m not completely sure), and availability of Provigil. It seems from reading this thread and others, that there is a difference between generic Moda and Provigil. I don’t see the point in taking the risk for a generic Moda that is too expensive and may not be as good.

I may be able to fenagle a prescription for the Moda here in the states (assuming my insurance covers it, otherwise it will be too expensive). I have some doctor’s appointments later this month, and may be able to push for something like this for fatigue and improvement from depressive moments. Although I am leery of telling my doc that I tried some of this Adrafinil. It works so well for multiple issues, that I should probably swallow my nervousness and just let her know. I will cross that bridge at the end of the month.

Anyway, it has now been 5 1/2 hours since I popped the pill, and I still feel fine. I have to question if this lower effect today has to do with tolerance, or lack of drug built up in my system. the lower effect is not that much lower, it just seems more familiar. Maybe I am just becoming accustomed to this drug faster than I thought. I guess I will see tomorrow. Anyway, see you guys later, thanks for listening and providing responses and theories.

Peace,[/quote]

       Excellent posting my friend! I didn't notice quite as much of a difference though the first dose or two certainly seemed to be the "freshest" response of all of them. Looking good and I like your attitude and procedures.

           Keep it coming bro.

                ToneBone
450

Hi Gang,

Today is day #4 with Adrafinil. I stated yesterday that I would either go to 2 pills (spaced 5 hours apart), or stick with one and injest Grapefruit juice for increased bioavailability. Today I decided that the grapefruit juice route would be the way to go, before upping the dose. I popped 1 pill and injested 8 oz of grapefruit juice (crappy concentrated blend is all I could find). I then had the usual breakfast without coffee, followed by another 8oz of grapefruit juice.

I have not noticed a huge difference over yesterday in effects. The onset of effects started around the 50 minute mark. I think that this probably due to Bushy’s theory about a buildup of drug over time. I do not think that the grapefruit juice had any real effect. oh, well live and learn I guess. I have no scientific means to prove this, but my gut tells me that grapefruit juice and Adrafinil do not have an increased effect when taken together. Does anyone else have any info or experiences with this combo?

Because I am leaning toward the “buildup effect” theory with this drug, I am thinking about sticking the week out with one pill a day. Other boards and info about Adrafinil are backing up this theory. Some people have sworn (on other info sites)that this drug needs to be taken consistantly for a period of time (more than a week?)before any real effects can be felt. This was not the case with me as I was able to feel great effects on the first day, and even better on the 2nd day.

I’m curious as to what will happen after 4 days straight at 1 pill per day. Will I get the slight increase in effect? Will the after effects be more intense on the week end when I come off again? I think only time and further experimentation will answer these questions for me.

You may notice that I stated 4 days straight at 1 pill per day. I still want to try 2 pills to see what happens. I think that Friday will be the day for that. I will give the rest of the week to see if I can notice any sort of buildup effect. regardless of what happens (unless things get TOO intense), I will take the 2 pills on Friday.

For a quick summary of the past 4 days, I would say that it has been an interesting ride. I only have positive things to say about Adrafinil, and I would reccommend it to any responsible adult. This stuff is great for increased mental clarity, and focus. please be aware that there appears to be no increase in PHYSICAL energy, only mental. I have noticed that it does have a place in the gym, even without the increase in physical energy.

Increased focus has helped me pay more attention to the mind/ muscle link while lifting. It makes it easier for me to TELL my muscles what to do as opposed to just using sheer force to throw the weights around. I also don’t get as destracted by the soccor moms chatting and idiot teenagers doing curls all day. Of course, more experimentation will be required as far as lifting goes. I imagine that this combined with a strength inducing AAS stack, would be REALLY cool. I will have to try this in the future (when I’m finally ready for it). Anyway, I’ve probably taken up enough space for one day. See ya later.

Peace,

451

Ok I read thru the thread and I’ve learned a lot. I am still confused and I would like a couple of questions answered if possible. If you give me suggestions I will research them on my own. I noticed how thru the thread the best would be replaced and new compounds would appear.

  1. What would a good cocktail be if I was looking for a brain booster that had the least amount of sides.

  2. What would be the best if I were to work the dosages for the best results.

  3. What compounds would work best at increasing neuromuscular junction activity or “cleaning” the acetylcholine receptors.

The last one is really important for me to learn about.

I know I am asking a lot, but I would really appritiate the help.

452

I’ll take a stab at this…

  1. In order of importance I would say:
    -Vinpocetine (dirt cheap, effective)
    -A racetam (Piracetam = cheaper less effective Oxiracetam more costly more effect
    -A choline source (other than Alpha-GPC they all seem similar to me in price and effectiveness with A-GPC being way out of my price range.)
    -Huperzine (pretty cheap and while I notice almost no effects alone it was the substance that brought mystack to the next level)
    FYI none of these have give me any sides.

  2. Dosage:
    Vinpo 10mg 3x day
    Piracetam ~ 3.3g 3X
    Oxi ~ 400mg 2X
    Choline seems variable to me depending on source, look up a a serving of Power Drive and go with that much choline.
    Huperzine 50mcg 2x

3.Centrophenoxine seems to be the concencus chemical for cleaning out the lipofuscin, aka brain crud. No experience with it myself but people here seem to have had success with it. DMAE seems like it could be a poor man’s centro given that half the centro molecule breaks down into DMAE.

  1. Random question to Bushy or other med-nerds. Is lipofuscin in anyway made of the same shtuff as a bezoar?
453

If traveling, by air, how do I take this stuff (and regular supplements as well) with me. If I take it carry on, would they question (or just take em). I guess the question should be has anyone ever traveled with their brain boosters and had problems. Sorry if this has been discussed already.

455

Being the nerd I am I’m currently rereading the Sandman graphic novel and there happens to be one story/plot thread where a magus needs a bezoar. After a little wikipedia-ing I remembered a Nytimes story about a whale bezoar (bizarrely prized for their use in perfumes) and it seemed to be a precipitation of random lipids/aminoes and other stuff.

From what little research I’ve done on lipofuscin it seems to be a pseudo random accumulation of body building blocks that coagulate together, kinda like a bezoar. Pseudoscientific ponderings and was looking for some actual medical input.

456

I am currently taking Paxil (anxiety) and Trazodone (problems sleeping). Does anyone know if there might be a problem with adding Adrafinil.

Thanks.

457

[quote]kingfin4 wrote:
If traveling, by air, how do I take this stuff (and regular supplements as well) with me. If I take it carry on, would they question (or just take em). I guess the question should be has anyone ever traveled with their brain boosters and had problems. Sorry if this has been discussed already.[/quote]

Adra is fine to take on the plane–it is not a scheduled substance. I left mine in the original packaging, and brought it and a bunch of phenylpiracetam in a baggy in my carry-on bag. The stuff did not even elicit a glance or question. Quantity was enough for 2 weeks; if there had been boxes of the stuff perhaps that would have raised some eyebrows.

458

Is there any recommended supplier for vinpocetine?

Like is the Jarrow stuff okay, or is there a better brand?

Same question for the oxiracetam.

459

[quote]coachld wrote:
I am currently taking Paxil (anxiety) and Trazodone (problems sleeping). Does anyone know if there might be a problem with adding Adrafinil.

Thanks. [/quote]

There won’t be a problem, but my advice would be to get off the paxil. SSRI’s gave me a ton of mental fog, and they didn’t help that much with the anxiety anyway.

460

If I can chime in as well. . .SSRI’s suck!

I have anxiety and depressive episodes. After years of experimentation with my doctors (trying prozac, paxil, celexa, wellbutrin, trazadone for sleep and buspar for anxiety at different times over 3 years), we decided on 1 drug that works. This drug is Effexor XR. This stuff is great, but VERY difficult to come off of. It is extremely unplesant if you miss a dose.

The positives are that you don’t get the sides of traditional SSRI’s. This drug works on 3 different substances in the brain (I cannot remember which three though, it has been a long time since I had to research it). Take a look at some of the Adrafinil stuff I have written over the past few days, it works great with Effexor XR.

Also, A word of advice, ditch the trazadone, that stuff is dirty and also sux. There are other medication combos out there that will probably work for you. It sounds like you are on a pretty crappy one right now (I was on that combo myself at one point).

As far as how you will react to Adrafinil, only you will know. For me, it does not aggrivate anxiety, in fact it kind of reduces it. But again, everyone is different, especially when it comes to mind altering or improving substances. If you are a responsible adult, I would reccommend trying it at least.

If you have any other questions about Adrafinil or depression and anxiety medications, let me know. I wish I had someone to help me with this when I was trying things out. I know now that Effexor is the way to go for me, I have been on it for 7 years now, and don’t really see any reason to change it. In combo with the Adrafinil, I feel like a teenager again.

Peace,