[quote]Defekt wrote:
I ask because I am wondering about the effects of l-tyrosine on these processes. This seems counter intuitive because I was under the impression that l-tyrosine increased the production of Thyroid-stimulating hormone, which is a glycoprotein.
[/quote]
I think all that extra tyrosine (raw material for T3 and T4) available to the thyroid gland has a bigger effect than any possible effect tyrosine has on TSH.
Just curious to hear your comments on this recent short article on the Kurzweil site:
A super-memory smart drug?
December 15, 2011 by Amara D. Angelica.
Suppression of the PKR molecule in mutant mice enhances learning and memory by lowering GABA release, compared to the process in “wild type” mice.
Could this be the “Limitless” breakthrough we’ve been looking for?
Researchers at Baylor College of Medicine (BCM) have discovered that when the activity of PKR - a molecule normally elevated during viral infections - is inhibited in the brain, mice learn and remember dramatically better.
“The molecule PKR (the double-stranded RNA-activated protein kinase) was originally described as a sensor of viral infections, but its function in the brain was totally unknown,” said Dr. Mauro Costa-Mattioli, assistant professor of neuroscience at BCM. But the activity of PKR is altered in a variety of cognitive disorders, so Costa-Mattioli and colleagues decided to take a closer look.
Super memory
“We found that when we genetically inhibited PKR, we increased the excitability of brain cells and enhanced learning and memory in a variety of behavioral tests,” said Costa-Mattioli.
For instance, they tested the mice ability to use visual cues for finding a hidden platform in a circular pool. Normal mice had to repeat the task multiple times over many days to remember the platform?s location. Mice lacking PKR learned the task after only one training session.
Memory-enhancing drug
The BCM researchers also found that this process could be mimicked by a PKR inhibitor ? a small molecule that blocks PKR activity and thus acts as a “memory-enhancing drug.” The next step is to use what we have learned in mice and to try to improve brain function in people suffering from memory loss, said Costa-Mattioli.
There are roughly 6 million Americans and 35 million people world-wide with Alzheimer?s disease and more than 70 million Americans over the age of 60 who may suffer from aged-associated impairment of memory. (Not counting the millions who just want to be smarter, which would be just about everybody.)
Unfortunately, there’s a secret government conspiracy to keep this drug out of your hands. OK, I made that part up.
But note the figure above: in mice that have been genetically engineering to inhibit PKR (right), the result is to lower GABA release. We know that GABA, the brain’s major inhibitory neurotransmitter, has an anti-anxiety or calming effect, which is why tranquilizers increase GABA production. So could using the PKR inhibitor drug also lead to increased anxiety?
Also, PKR is not just elevated during viral infections. PKR is thought to be a key player in cellular response to different kinds of stress: PKR activation leads to inhibited protein synthesis and transcription of genes involved in an inflammatory response. So you get smarter, but also get sicker if you have the flu or some other stressor? Or maybe just take it when you?re not under stress?
I have an email into Dr. Costa-Mattioli find out more.
Ref.: Ping Jun Zhu et al. Suppression of PKR Promotes Network Excitability and Enhanced Cognition by Interferon-γ-Mediated Disinhibition, Cell, 2011 [DOI: 10.1016/j.cell.2011.11.029]
^ Cool, thanks
anyone has any experience stacking aniracetam and piracetam?
I am at day 2 of my stack and while it’s early to draw conclusions it seems to have quite a definite effect on me.
Hey Guys, thanks for the informative disscussion. I started running a stack of noops 12 days ago, and I’m loving it. I’m a third year chemical engineering student, and I’m looking for a cognitive boost. My daily doses are:
Vinpo: 20mg X2
DMAE: 500mg X2
Aniracetam: 750mg X2
I’ve noticed an increased ability to “connect the dots” with new concepts, and an increased ability to retain information.
whould it be worth it to start taking a ‘racetam’ now?
i currently take vinpo and DMAE but was wondering if the ‘racetams’ had long term benefits as well… cost is an issue so i was going to just start next semester (finals just ended)…
[quote]MAF14 wrote:
whould it be worth it to start taking a ‘racetam’ now?
i currently take vinpo and DMAE but was wondering if the ‘racetams’ had long term benefits as well… cost is an issue so i was going to just start next semester (finals just ended)…[/quote]
piracetam is a use-every-day type thing, more effect the longer you’re on it; I have no experience of oxi or ani, but according to reports on these here threads (BBB and others) they are more of a use-as-needed for studying or test taking.
Aniracetam is also a use every day thing. I have been trying different dosages daily and have found that dosing twice at 600-700mg with ach precursors is the best way to go. I had tried upwards of 2500mg a day but it just left me feeling like this o.O, so I would say keep it lower.
Your brain is already a powerhouse, it just needs a little bit of a kick start to reach its highest potential. 700mg is both effective, and sustainable.
Be liberal with the ach precursors, especially the higher the dose of ani.
i see. thanks guys. i’ve been looking around for piracetam but only found one bulk supplier, theyre in australia and shipping is like $15 for 1 kilo…
so would $60 for product and shipping be a good price for 1 kilo piracetam?
[quote]bushidobadboy wrote:
Piracetam is now outlawed in the US, whilst other, more effective racetams are not.
If you want to fully reap the effects of neuroplasticity, you will take your noops continuously and for a long time.
BBB[/quote]
god dammit…
i’ve just started with the beginner stack you mentioned in the beginning of the first thread, IIRC. DMAE, Vinpo, B complex, Huperzine A, etc ED for the last few months. has helped but it seems like the racetams are best…
considering my current ^^^ supps, im guessing i should go with ani then?
EDIT: also use ALCAR, up to 5 grams at a time, and didnt seem to do much for me
Just finished my first semester of university.
Got a B in physics(did poor in the lab section and the final exam(63%) compared to the midterm(75%)).
Got an A in chemistry(final exam 82%), and biology(final exam 89%).
GPA 3.67 out of a 4.5 maximum(81.5% for reference)
Got a good taste of what uni is like now, so I’m expecting a better 2nd semester as I’ll be able to be better prepared as I have a better understanding of what I’m dealing with, test prep and all that.
[quote]bushidobadboy wrote:
[quote]MAF14 wrote:
i see. thanks guys. i’ve been looking around for piracetam but only found one bulk supplier, theyre in australia and shipping is like $15 for 1 kilo…
so would $60 for product and shipping be a good price for 1 kilo piracetam?[/quote]
Piracetam is now outlawed in the US, whilst other, more effective racetams are not.
If you want to fully reap the effects of neuroplasticity, you will take your noops continuously and for a long time.
BBB[/quote]
Any word on whether or not they are trying to outlaw ani? If they are I’m going to buy pounds of this stuff and stick it in a freezer…
[quote]bushidobadboy wrote:
[quote]MattyG35 wrote:
Just finished my first semester of university.
Got a B in physics(did poor in the lab section and the final exam(63%) compared to the midterm(75%)).
Got an A in chemistry(final exam 82%), and biology(final exam 89%).
GPA 3.67 out of a 4.5 maximum(81.5% for reference)
Got a good taste of what uni is like now, so I’m expecting a better 2nd semester as I’ll be able to be better prepared as I have a better understanding of what I’m dealing with, test prep and all that.[/quote]
The best bit is that as you continue with your study AND nootropics, the effects will begin to compound, due to neuroplasticity facilitated by the noops. You may find (as I did) that you become genuinely awed by your cognitive abilities and memory retention. I know I sound like a bighead saying that (see what I did there? ;), but it really is true and actually quite humbling when you realise the true potential of the mind. Or even just the bit of it I experienced 
If you are not class brainiac by the end of your final year, I’ll eat my copy of ‘Human Anatomy’ by Frank Netter - assuming you kept up the noop regimen, of course.
BBB[/quote]
I have about 300 x 500mg caps of oxi left, probably about 500 x 600mg ani left, and lots of other goodies. I’ll be sure to restock at the end of the semester.
I’ll be continuing the doses that you’ve recommended for my 2nd semester, and will update with those grades.
Instead of physics this term I’ll be taking calculus. Back in HS, my pre-calculus grade(~55%) was even worse than my physics(~63%) IIRC. So I’m looking forward to the upcoming challenge.
[quote]Defekt wrote:
Be liberal with the ach precursors, especially the higher the dose of ani. [/quote]
about to buy 180g ANI. running low on DMAE, but just wondering exactly how liberal you really mean?
[quote]bushidobadboy wrote:
Piracetam is now outlawed in the US, whilst other, more effective racetams are not.
If you want to fully reap the effects of neuroplasticity, you will take your noops continuously and for a long time.
BBB[/quote]
?
I just received an order for piracetam last month! From a U.S. company nonetheless.
Reading this right now spurred me into a quick internet search for “piracetam” and “banned” and I see alot of chatter regarding some believing it is banned and some saying “no its not”. Right now, I’ve got to side with the second group…it is still available it seems. Maybe it is being sold illegally?
What a shame. I know the opinion that the other racetams are better, but not for me. Piracetam is most excellent for me. Really sad if it is really true this is outlawed. Can’t get confirmation though.
^i’ve seen a few US companies selling too
It is strange countries don’t publish a comprihensive list of nationally banned substances. I know it would be ridiculously long, but thats not stopping people downloading it and using a search function. I am guessing they don’t do this because it would reveal a lot of substances people do not know exist, and the black labs might get a bit excited… hmmm…