I think an Axle is great for presses and curls, since it distributes the load over the hand better and can help with reducing/eliminating pain at the wrist and elbows. The only form adjustments I’d make are ones you’d normally make… just figuring out where your body works best.
For deadlifting and grip work, the axle can be great, but you’ll be limited by your grip. If you use the axle in conjunction with the barbell (or even with straps), you can get a mix of both worlds. Use the axle to train your grip and forearms, and use the barbell or straps to train everything else.
You can also put it high/on-top-of a rack and use it for pullups.