I think the TRT has a tendency to decrease certain hormones, vitamins, and minerals to supplementation becomes very important (obviously).
I felt my irritability and aggression increase when I was on once a week shots. Have felt basically nothing of the sort since settling into my twice a week protocol.
After a long while of feeling good with zero anxiety, but with some huge cystic acne and a libido that is not particularly prominent, I decided to slightly reduce my dose and have now been getting sudden panics, too. It’s really weird and scary but I’ve realized it’s 99% the TRT change. There is zero going on in my life that should be causing panics or anxiety. In fact quite the opposite. I am learning that I am extremely sensitive to both T and the dose I am on.
So it’s back to exactly .25ml every shot and I’m not changing that unless I have to. Wish you luck.
It sounds like changes in T and E2 effect you big time, maybe what you need is daily dosing, this would provide baby steps in T and E2 changes.
This is where daily dosing is perfect.
I wish I could. I think the most I would do is e3d. Aside from libido which is not really ideal at this point, I can’t imagine feeling better than I did for a full five weeks before I mucked with my dose. I basically woke up feeling like Superman every day.
I don’t want to go to sub-q and I have eight different injection sites on my quad that I am comfortable injecting into. So e3D or e3.5D is about all I can do. If I ever get stuck (so to speak) it’s at least an option.
Amazing that now along with my anxiety, which has quelled since yesterday morning’s shot, I am now a little depressed. I’ve had no depression to speak of for a couple months at least. You are right I am definitely sensitive to these small changes.
Thyroid get that fixed. It made a world of difference in my depression and anxiety (if you wanna call it that).
Also that e2 30 to 20 is horrid. Your brain needs estrogen. There is zero medical studies showing estrogen should be kept low. Zero. Even dr saya and Nelson Virgil have said e2 doesn’t need to be controlled. Only in rare cases.
Hormones of balance causes mood issues.
I see @systemlord continues to dish out the bro science.
High E2 means lower your T dose? It’s nonsense and the last thing you should be doing. Ensure you are doing as close to daily shots as you can or EOD. Many guys with your symptoms have improved by adding pregnenelone to their protocol.
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The OP has stated small dosage changes affect him big time, read his post. All he needs to do is increase injections frequencies to alter the T to E2 ratio, sure lowering the dosage would work, but more frequent dosing will more than likely lower E2, push TT higher and give him higher trough levels.
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When guys start exhibiting symptoms after being steady for a while it’s worth doing full labs again.
Total and free t
Thyroid panel
Lipid panel
Estradiol
Prolactin
Iron panel
Vit b 12 and folate
Cbc
Metabolic panel
And if u think other hormones are affected like adrenal
Do
Am cortisol
Acth
Dhea-s
And monitor blood pressure.
@systemlord I read the post and understood it. In your mind his issue is E2. If he lowers his dose E2 will go down. If he increases injection frequency, E2 will go down. I can’t believe you guys are still this obsessive about E2. All the men I am dealing with are trying to find ways to RAISE E2, since it is responsible for most of the benefits they are looking for, yet men here are trying to lower it. It boggles the mind. It literally boggles the mind. You are trying to lower the one thing that provides you the benefits, and then make posts about the benefits you are lacking. How long are you guys going to keep this up? Will you still be blocking E2 if I come back to visit this site in two years?
The following be benefits are obtained by E2. A heathy level to have these benefits is 60 pg/mL:
Improved libido
Improved erection strength
Improved cognition
Improved cardiovascular health
Improved mood and well being
Improved bone mineral density
Lowered risk of cardiovascular disease
Lowered risk of Alzheimer’s
Lowered risk of diabetes
Reduction in visceral fat
Reduction in brain fog
Those are just a few off the top of my head.
I ask all of you: why would you possibly want to REDUCE these benefits when the rest of us are RAISING E2 to get these benefits? What possible reason do you have? None. You have no reason. Thinking you have a reason and actually having a reason are two different things. NO MAN needs an AI on TRT. It is the LAST thing you want to be taking considering you’re trying to obtain the benefits listed above.
Optimized levels of BOTH testosterone and estrogen are KEY to being optimized. They work hand in hand. Until you understand this you will never feel as good or be as healthy as you could be. If the number scares you, stop measuring it. Optimize free T, eat well, get exercise, and get enough sleep. That’s it. That’s your magic formula.
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@dbossa what’s the thinking taking metformin for non diabetics?
Many swear by it. Some have had incredible results taking it and others don’t feel well on it. It’s one of those things you need to try for yourself and see how you react to it.
Was concerned with safety and concerns with long-term use. All you hear is good stuff about it was wondering what you and your drs think.
Thanks @dbossa
I have not heard of any detrimental long term use to date. Only people who do not tolerate it well.
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They find no reason not to take it. They give metformin to jsut about anyone that asks
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It’s almost like you joined a cult, you mind has been molded by someone else and you are incapable of seeing estrogen in two different ways, a deficiency which has consequences and excess which also has consequences.
If someone mentions something you have been conditioned to rebuke and then you ban that member from the group for thinking differently. You basically ban them when they don’t agree with you and that is a person who is narrow minded.
Demonstrate your evidence of consequences of ‘excess’ estrogen paired with optimized T levels. I’ll wait patiently for your answer. We have found none. There are only benefits.
Again, this is demonstrable. It has nothing to do with a view or opinion. I see it twenty times a day, every single day, with my inbox flooded with men who finally weaned themselves off the AI.
I don’t know how much more simply I can explain this. I can demonstrate this to anyone willing to wean off and allow their body to adjust over time, all while having optimized free T levels. If you don’t wish to try it, don’t say it doesn’t work, because that would be an argument from ignorance.
Is your position that there is no such thing as “too much” estradiol?
If so, then why aren’t we adding estrogen as well? Surely we could do that the same way we do testosterone and other hormones
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Explain what level is considered “too much”.
You raise estrogen by raising testosterone. They work together. There are some men that actually need to supplement with estrogen due to very low aromatase.
During the last hour, this is what I was doing:
Interviewing Dr Eric Seranno.
He didn’t answer the question, instead he went off on a tangent about men with low aromatase enzymes.
If estrogen is so important why are all men injecting exogenous estrogen?
Why not 400 pg/mL, why stop there? I mean if high levels of estrogen is of no consequence and healthy, it would be no different than having DHT at 5000.
Why not have an estrogen of 5000?
I expected more from you.
The benefits come from the conversion of testosterone to estrogen. They both need to be optimized. Now calculate how much testosterone you would need to attain 400. Are you being serious right now? This is your argument? How the hell would you want anybody to achieve a level of 400? Only 3 to 4% of testosterone gets converted. You do know how this works, don’t you?