Anxiety and Irritability Getting Worse on TRT

My SHBG was 40 before and now has dropped to about 30.

When I was in the 400s I felt horrendous, as well as when I tried 100mg a week for a while. Going back up to 150 got me feeling a lot better. Hard to describe, but I’ve slowly been feeling better and better but the negatives have been increasing parallel to it.

I will stress that the negatives did seem present prior to TRT but much less obviously.

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Also true. This is why the only thing I’m changing is adding HCG again which I wanted to do anyways for fertility reasons.

The best I’ve felt is when I’ve stuck closest to Dr Sayas plan (and he currently seems to suspect my thyroid is up to something).

Then the TRT is amplifying what’s already present and TRT is no cure for your mental issues.

You still should try lowering the dosage as I don’t think you even gave each protocol a chance.

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I’ve been considering this too. I’d hate to give up on the benefits of TRT just to “tone” myself down versus fixing the root problem.

Update with your thyroid results. Would like to see why your TSH is what it is. If you can try getting adrenals checked as well. If you’re super lucky try and get a Dutch test

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Just reading about that test now.

I’ll update once my thyroid panel comes back too. I had them add RBC magnesium as well as it feels like there’s a connection there, to me.

Its these studies that i know of. Maybe just wait for the results of the blood test.

https://onlinelibrary.wiley.com/doi/abs/10.1111/and.12862

https://www.nature.com/articles/pr1988160

Id go with more magnesium. If the glycinate give you insomnia take it in the morning. Or up your citrate. When I was having anxiety and negative ruminating physio put me to 600mg and it fixed it. He said some guys go as high as 1200.

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Yea adding this back in to see if it helps. If it does I’m down to find another form of magnesium that won’t give me diarrhea like citrate too

Yeah…glycinate does NOT do that to me. Other types definitely did affect my stomach.

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I wish glycinate and I were a better match. I just don’t seem to sleep as well and the next day I’m jittery as fuck. Oddly makes me really productive but isn’t very comfortable.

Also I’ve been reading that magnesium deficiency will cause a drop in thyroid hormones and thus increase TSH.

600mg of glycinate or citrate ?

I used glycinate

I use glycinate as well. Good stuff

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I am using glycinate too and i thought it was best to take before bed as it ensures better sleep.

@systemlord
How long did it take you to see such a low dosage worked for you?

I’d actually prefer to start lower and work my way up.

My TRT was derailed do to an iron deficiency. I started TRT in the beginning of 2017 and found daily dosing to provide excellent results by the end of 2018 at which point I discovered I was severely iron deficient the entire time and have stopped TRT for awhile until I figure things out.

Treating the iron deficiency is providing challenging, but have had erections and a libido for four months off TRT with 97-119 ng/dL, FT 3.15 ng/dL and learning I don’t need very much TT and FT levels to function normally which my previous 7mg (49mg weekly) daily protocol backs up.

Following up here to hopefully help others.

After 2 days on my old (i.e. year ago) 400mg dose of magnesium citrate, I’m feeling quite a bit better.

Going to keep it up and see how it goes. Fingers crossed that’s all it was.

Thanks for the replies guys.

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Funny how magnesium can work like that. I experienced the same thing. As a matter of fact when I went on vacation with my wife and kids over the summer I forgot to bring my magnesium and thought nothing of it. I was biting heads off and miserable 3 days in. Finally one day I figured it out and bought some citrate at a pharmacy (all they had). I was better within hours. Back to normal the next day.

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I really wonder why it makes such a huge difference for some people man.

I’ve got a lot going on in my life right now, but without the magnesium, it’s at the point I fear I’m going to get myself arrested or something lol.

I’m scratching my head as to how a supplement could do so much.