Like me, she’s 55 and, like most women, suffering the effects of age in a multitude of ways.
The dose is 0.25mg test twice a day.
A couple of medical articles I found showed “significant” increases in test levels within 15 minutes of consumption lasting for a few hours before returning to baseline.
Anyone have any experience/knowledge with this?
Thank you for the reply. I seriously doubt that my wife will agree to increasing her dose. She is terrified about virilization.
She is willing to give this an initial try but I think I’d like to see her on something that prevents the peaks and valleys and releases at a slower rate.
That seems like a way to take peaks and valleys to an extreme. I dunno, I’m curious to see how it turns out though, seems like it would be super up and down
Are you saying they’re all over the place anyways or the measurements are difficult to make? You got me on this one, I’m missing your point, lol
Well, I guess I got your point after all, haha. I got the comparison between normal vs. PCOS part, which is pretty interesting, I’m still reading through the study.
I’ve been trying to get my wife to get some hormone testing done. She had a little bit of testing done a year or so ago and her total T and free T were well above the normal range for females. Whether it’s related to PCOS or not, I have no idea… but she doesn’t like to listen to me when it comes to hormone stuff. She thinks all of this is crazy.
I just looked it up… both total and free T were double the high end of “normal” on her last test.
From my perspective you couldn’t have done much better. You provided directly relevant research without spamming 20 “somewhat related” papers, and you gave your own opinion/interpretation concisely without trying to make it seem as if it was anything more than your opinion.
I always find your posts highly informative and very valuable; for example I learned a lot from the posts from @unreal24278 on heart health you linked in a reply to another poster in my thread.
Her total T was 100ng/dL via LC-MS/MS. No results to compare to the other two charts.
The info you provided was great. Thank you again.
It also provided others to comment (like they have) which is always welcome.
I’m not too crazy about transdermal. Those receptor sites can become non responsive over time and they are not 100% efficient. I’d like to see her on subQ myself. There is a hormone clinic that is opening near us and she has mentioned checking them out. Maybe they would consider injectables to give that slower release. We’ll see.
This seems to be universal among women. Luckily, my wife recognized that she was changing and mentioned it to her Dr. They didnt even do any bloodwork, just prescribed the troche and said “see you in 8 weeks” or something.
Hey stud did you factor in the diurnal variations in testosterone levels in women?
@anon18050987 and i had a short discussion about this some time ago. The spikes throughout the day can be very beneficial compared to a slow release with stable levels.
In my estimation I wouldn’t discount the buccal tablets because of the spikes and falls but I would actually be inclined to try it for a good amount of time.
Another thing @anon18050987 did you see the discussion I had with @mnben87 on boldenone?
Also, always good to have your testosterone therapy optimization and outlooks here. You’re really specializing there I see.
@anon18050987 mind if I ask- what are your credentials? I’m assuming you are either qualified or a med student of some sort?
I am interested too. Always seemed like an engineer to me (just based on how he approaches questions, and the way he writes).
I did not. As previously mentioned, wife told the Doc about some issues related to desire, dryness, etc and presto, here’s a script. We are flying by the seat of our pants right now
I figured this after I posted. That would involve trying to cut the troches into smaller portions, which I’m sure the wife would tell me to stop messing with her meds!
Maybe I missed it above, but was it just the testosterone troches or did they prescribe progesterone or estrogen, etc?
I’d be very open and appreciative of a grammatically correct unqualified evidence based opinion every now and then helping me to try and get dialled in.
You’re clearly exceptionally well read.
Ok, I like the suggestion of readalot to take a small amount sub q just for some baseline T and then add the troches 2 times a day, preferentially at the time her natural test levels would spike.
The part of the study readalot provided is the interesting part. In pre menopausal as well as in post menopausal women diurnal rhythm of T secretion is present. There’s benefits to having a pulse of T instead of a continuous dose but you’ll have to make the determination through blood work how it works with buccal troshes.
Then there’s this graph from the first study:
It shows that T supplementation increases E2 the most (looks physiological to me) and:
The transbuccal route is a novel approach to administering sex hormones to postmenopausal women. Pharmacokinetic profiles of hormones suggest that physiological patterns of the concentrations of all natural hormones can be readily achieved by this route.
Id give it a shot for a few months before jumping to sub q T.
We’ve used them, barely, with just a few guys, in and out fairly quickly.
Had a woman use them, unknown to me, on top of her cream. She would take it prior to a workout. Once she went for her follow-up labs after a workout and, busted, her testosterone was mid range, for a guy.
Has she given any thought to a transdermal cream? If I recall correctly, troches are more expensive than the cream.
Just test
Definitely. Not going to rock the boat for a while.
