I’ve used both every other day and twice weekly schedules and did not notice a difference. In fact, I noticed no difference from once a week. That does not mean no one else does.
Most of my patients use weekly dosing. Those that use twice weekly notice a difference between that and once a week, obviously. Some, not many, use three times a week injections.
Honestly, I think this is often the case. But, if a guy tells me he want to try every other day, or daily for that matter, I’m not saying no. Whatever you do, I’d keep your doctor in the loop.
For the most part, I’d say no. But for those very sensitive to hormone fluctuations, it seems there are some. You can lower the (accumulative weekly) dose with more frequent injections, which may lower E2 for some guys. I’ve seen it go up in some cases and they feel better.
I have not seen a correlation between SHBG and injection frequency. For every guy with low SHBG levels using multiple injections per week, I can point to one with single digit SHBG taking once a week and doing great.
If you you are not happy with the results, by all means try something different.
While I think it is fine to play around with different doses and frequencies and “dialing in”, I think the constant obsession with feeling better can be counter productive.
It turns into a kid with a mouth full of candy holding his hand out for more. Reminds me of the guy who, on follow-up, told me his libido could be better. Turned out he and his wife were have sex twice daily.