Does someone know a medicine, a vitamin, mineral, a way to up-regulate LH Receptors (leydig cells)?
I was reading that there is evidence that the use of HCG in physiological doses up-regulates the size of leydig cells and therefore the response of them to LH, but i wanna know other ways to upregulate the leydig cells response to LH.
A good read, but nothing there that I can see that you can use other than extrapolation of:
“”“Estrogen and FSH upregulate LHCGR sites in preparation for ovulation.”“”
to the testes via the FSH receptor activation by hCG, which is limited.
HMG would be a better agent than hCG. Might be better to use both. But I think that most sources of HMG might already contain hCG, do some reading.
In rats ginger as been demonstrated to contain chemicals that are extremely efficient at acting as ant-oxidants specifically in the testes. They effect production of testosterone by the leydig cells and as a results testosterone increases by around 40% in two weeks (if my memory serves me correctly). The dose is approx 1g of ginger per 10 kg of body weight. For a 100kg man 2 teaspoons per day.
Ordinary ground ginger should be used. It may or may not work in humans - but it cannot cause any harm.
The link for an overview is below;
On the same site you will find a link for an amino acid D-aspartic acid which (via) a separate mechanism (LH increase) increases testosterone production by a third
I found this article in another page
Leydig cell desensitization from hcg has been shown to be blocked/minimized by Nolvadex. This occurs by supressing hcg’s ability to inhibit the conversion of 17 alpha hydroxyprogesterone to testosterone.
Modulation of Leydig Cell Androgen Biosynthesis and Cytochrome P-450 Levels during Estrogen Treatment and Human Chorionic Gonadotropin induced Desensitization
The similarity of estrogen dependent lesions to those produced by hcg treatment further indicates the involvement of endogenous estrogen in the development of the microsomal enzymatic lesions in gonadotropin-induced desensitization of testicular androgen production.
Tamoxifen suppresses gonadotropin-induced 17 alpha-hydroxyprogesterone aculation in normal men.
Simultaneous administration of hcg and the estrogen antagonist Tamoxifen (20 mg twice daily) almost completely abolished the hcg-induced steroidogenic block localized between 17 OHP and T (17 OHP to T ratio at 24 h, 1.1 +/- 0.1 times baseline; P < 0.01 vs. hcg alone). These data indirectly suggest that, in man, the hcg-induced steroidogenic lesion might be mediated through its estrogen-stimulating effect.
Effect of an antiestrogen on the testicular response to acute and chronic administration of hcg in normal and hypogonadotropic hypogonadic men: Tamoxifen and testicular response to hcg.
17OHP rose with hcg alone, but not with hcg + Tx in both groups. E, sex hormone binding globulin and 17OHP/T ratio did not change after treatments. hcg tests: E increased 24 h following hcg administration in every test. The ratio 17OHP/T rose at 24 h in the first and second test but in the third test it did not change. These results support the role of E in the acute hcg-induced Leydig cell desensitization.
[quote]Cymru wrote:
In rats ginger as been demonstrated to contain chemicals that are extremely efficient at acting as ant-oxidants specifically in the testes. They effect production of testosterone by the leydig cells and as a results testosterone increases by around 40% in two weeks (if my memory serves me correctly). The dose is approx 1g of ginger per 10 kg of body weight. For a 100kg man 2 teaspoons per day.
Ordinary ground ginger should be used. It may or may not work in humans - but it cannot cause any harm.
The link for an overview is below;
On the same site you will find a link for an amino acid D-aspartic acid which (via) a separate mechanism (LH increase) increases testosterone production by a third
[/quote]
Ginger may be a good choice, but the case is this: if someone is producing enough LH in the anterior pituitary, but the leydig cells arent responding to their command (leydig cells desensitization to LH) what is a good way to upregulate leydig cells, medicines, food, vegetables, drinks, supplements to upregulate leydig cells??? anyone.
I read somewhere(sorry I’ll look for it) that proper vit D levels are required for LH to work effectively
Also:
Desensitization
THE LHCGRS BECOME DESENSITIZED WHEN EXPOSED TO LH FOR SOME TIME. A key reaction of this downregulation is the phosphorylation of the intracellular (or cytoplasmic) receptor domain by protein kinases. This process uncouples Gs protein from the LHCGR. Another way to desensitize is to uncouple the regulatory and catalytic units of the cAMP system
MAYBE IF I USE A CYCLE OF STEROIDS AND LET LH SHUT DOWN, THE LHCGRS MAY BECOME SENSITIVE AGAIN? WHEN HPTA RESTARTS AGAIN?
…in this country tney dont sell HMG