TRT Not Working

Yeah but I have more than one lab test and they all indicate similar results:
Total T: 250 to 350 ng/dl
Free test 10pg/ml
SHBG: 15 or 16 nmol/L
Albumin: 4,24g/dl

The total T is super low, so of course free T will be also low even with low SHBG

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Unless you got the units screwed up then something is not right with your reported numbers. I would say lab error or wrong units.

If your units are correct then your Free T is actually 1 ng/nL, which doesn’t sound right.

If this is true and the units for Free T are actually ng/nL (it’s possible that the lab units are reported incorrectly as well…has happened before), then your Free T is actually a little higher than the calculated value…

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As @vonko1988 stated, your total T is in the tank…

Actually, there are a ton of studies on this that have nothing to do with TRT. There is a lot of information linking higher SHBG to longevity and better health. Low SHBG is generally a sign of health issues, not specifically testosterone issues.

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Yes total T is low, however in one blood test that I did after hitting the gym like crazy for a month my total T was around 500ng/dl and free t was still like 12ng/ml

Yes, free t should be ng/dl also right

Keep an eye on your Albumin and make sure you are staying well hydrated.

@dbossa, I’m following the advice given for guys with low shgb since I’ve been frustrated about not feeling anything. The last labs I got that showed free t I was at 1070 total T and 326 Free T. I don’t remember the exact protocol but I know it was probably 100mg per week. So I’m hesitant to do a 200mg per week dose if my free t is already high. Granted that test was March of 2018. It definitely does make sense to increase until it works.

@bantis you were getting 326 pg/mL (32.6 ng/dL) free T with only 100mg per week? Wow! You’re a lucky one in that case. I’m personally at the opposite end of the spectrum: 250mg a week gives me a free T of only 28 ng/dL in comparison, and I have low-ish SHBG (18-20). Funny how these things work sometimes.

@dbossa, that’s why I’m not sure what to do. It’s really frustrating.

If it’s any consolation, I know guys that have to go as high as 60 for all their symptoms to vanish. Not saying this will be your case. Just saying I’ve seeing it rather often.

Holy hell!! That’s a ton.

And I thought my 39 was high. Maybe I need more :man_shrugging: :

Question, is it possible that trt is not working on me on a weekly injection but it does on a 3,5d injection? I have no problem with trying daily injections but in the long term i would prefer less frequent shots

FREE T3 is low if thats out of 4.2 or 5. Very low … a reason for TRT not to be working in men is Thyroid or not enough time on trt or dose.

200mg a week and 4 months 100mg a week . thats a good amount of time. sure you need to give it a couple more months, but by now you should atleast feel something.

i would discuss getting ft3 to top of range with the doctor. just about anyone who knows how the thyroid works will tell you your ft3 is not normal and it is low.

I have 2.68 on free t3 and the lab range is 1.88-3.18
Yes, I mean I have one month with weekly injections, before it was each two weeks, but I agree that I should feel something, cant understand why, is frustrating

I mean I feel sth but very little, like erections are a little bit harder, still not enough. And I feel a little bit more muscle mass, but no mental effects and no energy still

Switch to Daily.

Im surprised. How is free t3 only to 3.18. its 4.2 and 5 and 6 in other labs. i think they are lowering these labs even more. 2.68 is low. check out stop thyroid maddness website and read up on it. free t3 should sit at the top of range even if its 3.18. 3.0 on my lab is 3.0 on yours. the fact that they lowered the top end is a bit frightening.

when i starte thyroid my TRT started to work. thats after several months of TRT dosing. i didnt feel anything at all. i had serious fatigue , depression and etc.

Your thyroid is perfectly fine. No reason to suspect any problems there.

Reference ranges depent to the assay type. The majority of assays are relative and not absolute assays, ie your sample is measured against a standard sample. Different assays show a different response towards the analyte and thats why different assays have different ref ranges. There is no point in taking the outcome of one assay and compare it to the outcome of another assay without taking the individual ref ranges into account.

An absolute assay would be the old fashioned way of determining the hematocrit. Blood is centrifuged and the %of cell volume of the entire volume is determined. Such an assay is comparable between labs without considering the ref ranges because of its absolute nature.

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You are mixing up statistics (probability of one person to develop cancer based on population studies) with mechanistics. Mechanisticly cigarete smoke has been proven to be a carcinogen on a molecular level, ie in those who develop eg lung cancer and smoke there is a high probability that smoking caused the cancer. Smoking increases the risk of cancer becuase of the proven carcinogenic potency of many substances cigaret smoke contains.