TRT Hasn't Worked for 2 Years. Help?

Defy wanted to start me at 120 a week even after they knew my previous clinic had 200mg a week on paper.

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Hey guys,

So a little update, I have been off TRT and man… lesson learned. If I thought my erections were bad before… this is something else. I essentially cannot get hard right now… at all… complete loss of morning wood too… delightful! No idea where I am sat numbers wise but I would imagine bottomed out T & E2… not fun.

I have been thinking about my TRT journey and 95% of it was sat in the 80-125mg relm (aside from a brief 6 weeks experiment with 175mg), and ALWAYS daily administration. I am now thinking, as a way to cover all bases to see if anything truly makes a difference, is to start low, with a variety of dosing protocols, and work my way up gradully until I find what works best for me. However making sure I leave enough time on each, as I am looking specifically at erections, and I know this can take time on a protocol to show its effects.

Inspired by @dextermorgan (shout out) for this one, as I believe I have read somewhere he tried this successfully for himself. So the idea being something like…

125mg once a week - 8-12 weeks
125mg twice a week - 8-12 weeks
125mg EOD/daily- 8-12 weeks

If no joy there go up to…

150mg once a week - 8-12 weeks…

Etc etc. It will take time, but my thought process is exactly that, take time to see what works and using this method I wont ā€˜skip’ past any protocol that might work, so to speak. I think once, twice and then dailys are enough for this experiment. I could add 3 x per week and EOD etc, but that will take a very long time and to be honest, not sure such a small change would make such a difference.

If one of these seems to be working or promising, I would likely continue it for longer than the 12 weeks, I have heard some say it takes 4 months or longer on the same protocol for a positive impact on erections. This WILL take time, but I guess its the best way for me to find what works, instead of me going from a low a dose, that not working then trying a high dose etc, this is a way to test all the doses and frequencies. I can always lean more on PDE5s throughout the rough patches early in a protocol change to get me through.

I guess looking for feedback and thought’s on this? Also, do you guys think ive got this the right way round, low to high? Or think I should start at say 200mg and go down?

Thanks guys, really appreciate it.

Not a bad idea. I’ve thought of doing this at times. Dropping it altogether for a few weeks first and then starting low dose and building up. Nothing more than twice a week at most though for frequency.

Yeah to be fair I am a little nervous to try once a week, especially on 125mgs a week. What will my trough reading be, maybe 500, 600 etc but ive got to remember, this is designed for well being and sexual function, and I cant get tunnel visioned chasing numbers. Plus, plenty out there on once a week doing just great, I need to try what ive never done before

I would definitely start with once per week.

And a trough of 500-600 isn’t all that bad. You may feel best at trough.

I always tend to feel better at trough regardless of the dose or frequency

The above idea sounds great and interesting.

500-600 trough is no problem, that is literally the average test levels of 21 year olds. Only muppets like dr nichols run around screaming that high-school kids have test levels of 2000 or ā€œback in the day 200 years ago the average T levels among men was 1300ng/dl!!ā€ - yeah, right bro.

Anyway, regarding:

ā€œI have heard some say it takes 4 months or longer on the same protocol for a positive impact on erections.ā€

I see that shit from time to time and to me it sounds like pure BS. I dont know where the heck guys come up with their shit. I notice changes within a few weeks, IF EVEN THAT, I can notice changes in two damn weeks (ā€œMuuh it takes 3 months for ur androgen receptors blablaā€ SHUT UP, NO).

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ive read a lot of people do. I hypothesize that it’s because your testosterone is lower at trough, but estrogen is still a bit higher at that point. Again, just my thoughts because estrogen kinda follows test.

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In theory that makes sense. Less frequent injections may be beneficial if that’s what’s happening, although I wonder if something like daily injections would help maintain the e2 levels without the bigger spike in test after one large shot and throwing off that balance. Then again it could backfire in the exact opposite direction. Just thinking (or attempting to) out loud.

Actually this is not a bad idea at all. It cant hurt worse come to worse you just get rite back on testosterone. I my self have been off for over 6 months now and have better erections then when i was on testosterone. I refuse to go back on no matter what. So If i was you I would stay open minded to different ideas.

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As much as I like certain things TRT did for me. Erections and libido is definitely not one of ā€˜em.

Sadly this is starting to become more and more of a reality for me. Did you ever try to severely reduce dose???

How I wish I can be one of those ā€œI need to keep my dose at 120mg otherwise my gf/wife just can’t keep up if I go higherā€

The thing is in my case erections took a nose dive PRE TRT, all of a sudden. This is what led me to start investigating, which led me to Testosterone and then TRT. My levels were frightening low, from memory a total T of 190 NG/DL at age 29. Its just that the TRT hasnt helped in that department. Had my erections of been okay pre TRT, jumped on TRT and they got worse, I 100% would have tried coming off by now

Your levels sound like mine. On Week 4 of TRT and my libido/morning wood etc has all been ā€œfixedā€. Still have 2 more weeks before I get blood tests done, but I imagine my Test no longer resembles an 80 year old.

Based on feedback here I do 2* 60mg week injections following the TRT doctors 120mg (who recommended 1* a week) starting dose.

I notice this too actually lol no matter the dose. Also in that sense is why I don’t like super high frequency because there is no real trough.

Hey man - not sure if you resolved this, but I see in my work, that a small subset of individuals (but maybe larger than we think) firstly, respond poorly to long esters, but secondly, only get erections back when doing hybrid fast acting protocols (like Prop/Cream), in HIGH doses.

Unfortunately, not a lot is known about the uptake of exogenous testosterone into TISSUES, where it matters (IE: penile tissues, triggering vasodilation, NO signaling, and optimal endothelial function). And high doses of Prop/Cream together, seem to add enough FREE testosterone to the mix, which fixes this issue for folks.

Additional health management might be in order to tolerate such doses, but this is the fix for non-responders, particularly with erection issues. 70MG Prop/3 pumps transcrotal cream every day, or every other day would be a good starting point.

Source: I do this for a living, and have seen the craziest cases of non-responders to exogenous test. They all always need to peak at 2500-3500NG/DL, with free test in the 500-1000PG/ML range.

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Hey man,

No, unfortunately. Nothing really works. Not that ive tried anyway, and ive tried all I can (no access to cream, but tried everything else).

Likely going to come off T as its made me feel asexual. Everything was better with hormone levels in the gutter.