low carb/carnivore will absolutely suppress you appetite. that is solid evidence why it does that.
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I agree that low carb diet like keto or carnivore work well. The issue is that those diets are major lifestyle changes. The bigger the lifestyle change the lower the long term compliance. Gatherings with friends and family, or going out to eat are difficult on those diets. The grocery bill is a lot higher.
I agree with @swoops39 take on it. The drug helps with diet compliance.
I also disagree with the notion that everyone will gain the weight all back or mostly back. While I think that is true for many people, I don’t think it is true for those using it more so as a PED. By that I mean the people that are doing the things to get to their goal already, just using it to speed up the process. It might help them go from 0.25 lbs/week lost to 1 lb/wk lost for example. They would eventually get to that goal, just it would take 4X as long.
In BBing or strength sports, being able to effectively cut is pretty important IMO. Someone who can cut at 1 lb/wk isn’t losing a ton of muscle, but is also able to spend 1/4 of the time cutting as the person who only manages to cut at 0.25 lbs/wk. Then they can spend a lot more time in phases where they are building muscle.
reading that people lost ~40% lean mass no exceptions. no idea if they worked out or not.
so it may work…if you make significant lifestyle changes while using it.
unless you are morbidly obese…this stuff is is a clear no
OK, so you only took one dose? How much do you need, or want, to lose?
I’ve seen some of the studies, which seemed kind of pointless and obvious. If you stop doing whatever you did to lose weight, regardless of the method, diet, exercise, medications, a combination of them, most will gain weight back, or at least some of it.
From my perspective, the jury is still out. We started using it about 18 months ago, and only then for those drastically obese, 350+lbs. They’ve lost up to 100lbs, but are still using it. As word got out, more and more have been requesting it. Of those that used it and stopped at their goal weight, many have lost 30-50 lbs, most are keeping it off. Some have gained 10-15 back, but not many of them. Of course, most are on hormones, eating better, and exercising. I’m a big strength training/protein guy, so perhaps that will contribute to better long term outcomes.
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This is also seen in regular caloric restricted diets, or very close to it.
This is a review of studies. The amount of lean tissue loss gets higher the leaner the individuals are.
For lean individuals it may be as much as 50% lean tissue that is lost.
For fit individuals (this section is looking at Army Rangers), the percent lean tissue lost was 40%. My hypothesis is that since the weight loss was so rapid in this study, that more lean tissue was lost compared to a few of the other studies in the paper. Rapid weight loss is common with GLP-1 drugs. People are losing weight at about the same rate as the ranger study. Perhaps lower doses and slower weight loss would preserve more lean tissue?
My conclusion is that the 40% lean tissue loss with GLP-1 drugs would be pretty concerning if that wasn’t also true with regular diets.
All things equal, Obese individuals have more fat and more muscle than normal weight individuals. Losing weight makes the obese individual resemble the normal individual.
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I agree with you on this. I tried it for a few months during my contest prep. I used the typical protocol of .25mg/wk for 4 weeks them bumped up to .5mg/wk. It wasn’t until the second moth when i noticed a difference. I don’t think one dose of any size would make any difference.
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I tried to see how my body would react, it went completely south thats when I stopped.
on diet/lifting alone - i had 2 dexa scans 3 months apart, last one was 1 month ago, so i probably made more progress since then.
i lost 8.6lb fat and gained 1.2lb lean mass in 3 months. i did different diets (anything from keto to carb) while always maintaining a 300-500cal deficit and keeping protein at 1.6-2g/lb weight.
not opposed to this drug (or any drugs), you just need to be very cautious of protein/exercise etc
This is done on diabetics right? Not accounting for protein intake, likely very obese, little to no exercise. Probably means very little for ppl like use using this along with AAS or TRT.
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I havent’ seen any studies on GLP users that are healthy, working out, eating high protein diets while also using AAS/TRT. I’d bet that lean mass loss % would be much lower in that group.
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Not sure if anyone is still following their GLP-1 protocols in this thread, but thought I’d update since it’s been a little while back on Liraglutide. I was taking 1-2mg every morning and feeling like garbage during the day, but losing weight, so I decided to see if I could go back to just .1-.3mg at night like I did in 2021 and lost 20+ lbs. It’s been five days taking .25mg at night when cravings would usually strike and it is working again to block that desire to eat. I am however still very hungry, I can feel it during the day and before bed, but the need to eat is totally gone. It’s like I don’t care that I’m hungry. I’m guessing maybe some sort of leptin response? Maybe GLP helps with leptin sensitivity? Curious how everyone else is doing, if they are still on their protocols
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I started Semaglutide and am to take my seventh shot this week. Nausea, headache and fatigue for me for the first two or so days after the shot then it goes away.
The last shots of .25 didn’t really give me side effects so I believe my body is adjusting to it somewhat and I hope that’s the case with the second half of this round.
I’ve lost 15lbs during that time and haven’t changed my meals, I’m just not eating as much. I’m also not snacking in the evenings like I used to which is nice.
I wasn’t able to get my .5 dose of Wegovy due to it being backordered so I switched to compounded. I have to pay for it now but at least I don’t have to lose any progress. I’ll switch back once supplies are back up and it’s available again since there is no out of pocket for me.
I’ve read the half life is about seven days but I find my appetite increases about five days in, not drastically but it is more.
I wonder if going compounded and splitting the dose would give more consistent results with appetite suppression but I don’t want to try that until I’m confident my body’s adjusted to it and side effects are minimized.
I’ve found I have more energy than I did before other than the initial days after the shot. Im planning on getting back in the gym like I used to starting Monday. Im hoping the Semaglutide and trt will have some synergetic effect but we will see.