Well, dopamine is an important one because itās associated with seeking behaviour. Feeling the need, the drive to accomplish or do something. Sexual arousal is linked to dopamine in that fashion.
Noradrenaline and adrenaline also increase (some dopamine is converted to produce these neurotransmitters) to enhance focus and readiness as a means to be able to āperformā.
These NTās are upregulated before and during sex. Serotonin and oxytocin (which is a hormone that also acts as a neurotransmitter) are released after ejaculation (oxytocin also helps move sperm) to calm down.
There is also a connection with low serotonin and premature ejaculation (in fact, short-acting SSRIs are used for the treatment of premature ejaculation). Serotonin playing a role (in general, not just with sex) in being able to delay gratification.
Itās NOT you raise dopamine = you increase sex drive. Rather itās the opposite. You have sex, you release dopamine, it gives you a pleasure response and over time you will crave that satisfaction more.
So itās not like you can take a supplement that raises dopamine and BOOM increased libido (although there might be an increase due to overall feeling more positive, better and more confident).
Furthermore, any supplement that raises dopamine will also decrease serotonin (and vice versa). So playing with neurotransmitters is kinda complex.
Plus the main issue of someone with low dopamine activity can just as much be an issue with dopamine receptor resistance. Basically your dopamine receptors have a VERY low response to dopamine even though you are releasing it.
This can be genetic but you can easily desensitize your receptors when you bombard you stimulate those receptors with a stimulus that far exceeds the natural release you can produce.
This is the case of blue light: smartphones, laptop, TV, video games, etc. Too much of these (even a moderate amount) will make you less and less responsive to your own natural dopamine release.
Drugs like nicotine, large doses of caffeine, extacy, amphetamines can also āburn outā those receptors.
I think my dopamine is messed up from prior SSRI use. I have sex 5+ times a week so I doubt having more would help.
Thank you for the detailed response!
What is your opinion on citicoline (CDP choline) supplementation to raise acetylcholine levels?
I would normally choose alpha-gpc but there was an interesting discount on one of my go-to webshops. I did some research and found out that, apparently, bioavailability of citicoline is much better than choline bitartrate.
Iām not sure though if citicoline (or itās derivatives) is able to pass the blood brain barrier like alpha gpc does.
I want to use it pre-workout and pre-work (used sparingly at times when I need to put in a lot of work for my business) to maximize focus, retention of information and improve learning capabilities.
I currently train 3-4x per week and I was planning to only use citicoline on training days to allow my brain some rest on off days.
Is CDP choline something that you would recommend for this purpose? In other words, is it a decent alternative for alpha gpc? What daily dose would you recommend (or start with)?
Now, you also mentioned the importance of receptor sensitivity, methylation efficiency and enzyme activity in your courses so plan B for me would be to mess around with Huperzine A if raising acetylcholine levels doesnāt improve my cognitive performance.