Too Much Weight Loss on CJC 1295 / Ipamorelin

Pharma
1

Wondering if anyone else experienced too much weight loss while on this peptide combo.

I’m 7 weeks into my 2nd cycle of CJC 1295 / Ipamorelin (600mcg each) in troche form, taken 5 nights a week.

The first cycle I stopped early because I felt I was losing too much weight. Wasn’t sure that I would bother taking the 2nd cycle, but I had already paid for it (through a men’s health clinic), so i figured I’d give it another shot. The experience is the same this 2nd time around. I’m looking the most ripped that I ever have, almost starting to see abs, but feeling like I am losing too much weight/size. I’d say I’m somewhat lean to begin with. 6’5" 245ish (tiny calves…HA!)

I’ll most likely end this 2nd cycle early, again.

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What is “too much weight”?

You’ve given no quantifiable metrics.

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You’re right. My original post was a bit rushed.

I started TRT and peptides last summer, at age 49. Prior to that I had been natural.

Before starting the TRT & peptides I was about 250#. My TRT dose is 120mg/week and the first peptide I started with was Ibutamoren (for 3 months). Pretty quickly, I shot up to 265#. My arms went from 17.5 to 18 and overall I looked much bigger.

After the ibutamoren 3-month cycle, I switched to the CJC 1295 / Ipamorelin cycle. Within a couple of weeks, I noticed I looked leaner. I started weighing myself once a week and was dropping weight consistently. Ended up stopping the CJC cycle at about 10 weeks, after dropping down to about 245#.

I had signed up for a year of peptide treatment, so I then started the 2nd ibutamoren cycle. I put on a few pounds during that 3-month cycle.

I reluctantly started the 2nd CJC cycle, in late February, but just stopped last week. Bodyweight is now 240#, arms have gone back down to 17.5 (however, I’d argue that they look bigger because of the increased definition).

In hindsight, I’m wondering if I should have just done the TRT and not tried the peptides right away. The men’s health clinic made them sound amazing, though, so I figured I’d give it a shot.

In summary, my body composition has changed quite a lot. I’ve gone from a 36 waist to a 34. XXL shirts now look quite loose on me. These are changes I wasn’t expecting. But with all of this change some great things have occurred in regard to my overall health. My lipids have improved so much that my PCP took me off my statin. I had been on statins for close to 25 years. And my libido has absolutely skyrocketed - this was the main reason I visited the men’s health clinic. Not sure if that’s just from the TRT, or if the peptides are also helping with that.

Before I started lifting, in my mid 20s, I was incredibly skinny. 6’5" and about 165#. I think because of how skinny I was for all of my youth and young adult years, I freak out a bit if the scale isn’t being on my side.

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So to summarize, you look better, feel better, are overall in better health, and you stopped taking CJC because it was helping you with these things?

I think you’re crazy for doing this lol. CJC certainly isn’t “needed”, but if you’re crushing goals, I really don’t see why you would stop until you get there. Just my opinion.

Do what you feel comfortable with, you’re on the path to looking even better so I wouldn’t change a thing.

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At age 49, you improved your lipids so much that you are no longer using statins…your libido skyrocketed…your waist trimmed up 2 entire inches. IMO those are the things you should maybe focus on, instead of some “lost size”. Taking what you have said,…being the most “ripped you’ve ever been”, and you’re just starting to see abs…thats not ripped, that is starting to become lean. Which suggests that the size you lost, wasn’t of high quality to begin with. Good news is, your health improved dramatically, and you’re now in a good spot to improve the quality of your physique over time. JMHO.

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I did 3 months of the same combo peptide, only in subQ. It did nothing for me. I felt like the guy with two same pictures side by side with caption “in 3 months Bob lost $1200”.
Besides OP has anyone had success with the stuff? I’m late 40s, slightly overweight. I was supposed to be the perfect candidate.

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Interesting… what did your diet look like?

What do you suppose the “perfect candidate” looks like for this?

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Great questions.
Not going to lie and tell you my diet was spot on every day. Not the case. I eat 75-80% well. Same then as I do now. I didn’t change anything in that regard.

I was told I was ideal given my age (48 at the time) and the age-associated decrease in GH, with bmi right at 30, so so some fat to lose.

I’m not saying the stuff doesn’t work, but I didn’t have the experience I was hoping for. Yeah, was looking for quick fix by not tightening up my diet…

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I think we identified the problem. No pill or syringe will fix what you’re putting in your mouth. Plenty of resources here to educate/motivate yourself to get moving in the right direction.

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Agree and I’ve been at it long enough t to understand. My point is that the stuff didn’t work for me. All things being equal, same diet, same work effort, but adding something that’s purported to decrease body fat—didn’t happen for me.

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I don’t believe there is any data to support the claim that CJC 1295 ALONE will cause weight loss. In fact, I think you will find almost everything saying the opposite.

CJC 1295/Ipamorelin injections do not guarantee desired results. To experience weight loss and burn body fat, you must also make lifestyle adjustments when it comes to diet and exercise.

For instance, a poor diet and lack of exercise can have negative impacts on your health and lead to weight gain, even if you follow the correct treatment protocol. However, this CJC 1295 peptide therapy can help you achieve health goals more efficiently when combined with proper dieting and exercising!

It might cause a mild increase in metabolism RE increased IGF-1 levels, but we’re talking about a rounding error amount of difference.

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Did you have your IGF-1 tested before/after?

My IGF-1 was 90 prior to starting TRT & Peptides. 6 months later (so after a cycle of Ibutamoren and a cycle of CJC/Ipamorelin) my IGF-1 was 290 - so I definitely got a boost in GH.

Not sure how much it will drop if I stop the peptides.

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What’s strange is your dose. From everything I’ve read; Ipa/CJC have a very low saturation dose (1mcg per kg of body weight). The clinic giving you 500mcg of Ipa pre-bed seems like a huge over-dose for no real benefit and brings the risk of de-sensitization.

Ipa/CJC benefits come from increasing the number of spikes, rather than the size of the spike (Ipa’s half life is ~2 hours). So pre-bed, wake up (esp if you have cardio planned) and post workout would be very effective.

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While 3 months with peps is enough time to see modest to possibly significant increases in bloodwork results, and also a positive impact on sleep quality, and maybe skin appearance … by itself, it’s not likely long enough to see a huge impact in the mirror, all other factors being considered.

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He is taking the peptides orally in troche form, not injecting them. Is that an effective way to dose it? It seems like the stomach would destroy most of the peptides.

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Troches are taken sublingually, so they are absorbed under the tongue and don’t go into the stomach.

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The sleep quality is something I haven’t seen, however, I think it may be due to the TRT. I feel like a teenager again in regard to my libido, which causes me to wake up numerous times throughout the night.

No complaints, though. As I mentioned in my OP, the main reason for going to the men’s health clinic was for diminishing libido.

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Was your 3-month cycle really $1200? Granted, peptides are expensive, but that seems very expensive.

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Then mission accomplished…along with something more significant, no statins. The recomp is a nice added benefit. We’re in the same age bracket. While being yoked is awesome, i think focusing on overall health, while chasing a mature and conditioned physique is the way to go once you get a certain age. Throw the scale away IMO and focus on the mirror, performance in the gym, performance with the sig other, and general health markers.

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I would have to check, but I’m certain was $3-400 per month. This was 2 years ago.
I’m glad it worked well for you. I would’ve been happy with your results!
And I agree, overall health—looking AND feeling better is what it’s about at this point in my life.