I’m 42. I’m on TRT with HCG and a bit of Cabergoline.
Recently my conversion to E2 suddenly stopped and my E2 stays around 33 (sensitive Labcorp values), which is low for my erections, I need E2 around 40-50. My E2 used to raise at the rate of approximately 12 points per week and I’ve taken Anastrozole when needed.
I didn’t change the TRT protocol, the only thing was that my last Pregnyl bottle was 9 months expired when I started it.
However, recently I’ve discovered that I have methylation issue as well, and after talking to a specialist I started taking:
Folate (around 2,000mg)
Methyl B12 (around 1,000mg)
Active form of B6, Pyridoxine P5P (825mg)
Potassium
Magnesium
NAC (N-Acetyl Cysteine)
Zinc Picolinate increased from 30mg to 60mg (it has 2mg Copper so Copper increased to 4mg).
I’m aware that I can raise E2 by taking more HCG. But what hay have caused this sudden stop in estradiol conversion?
Are ANY of the above listed supplements known for lowering estradiol conversion?
Stop all supplements and stick with your protocol. Its the only way to know. Right? Adding T is not as complicated as everyone makes it out to be. If you eat right and sunbathe, you should live to 85 with a hard dick in some very enthusiastic piece.
My T level didn’t seem to change after I gained weight. Although… It’s hard to notice since it fluctuates with time of blood draw relative to time/date of T injection.
Is your line of though such that weigh gain might have increased demand for T while I didn’t increase T, and thus lowered T slowed conversion to E2?
No clue. My dose went from 180mg/week to 210mg/week too… and it still went down somehow. And my body fat has probably gone up if anything, so I’m really not sure how to explain it.
I’m now sure that my lower estradiol has nothing to do with B vitamins. I stopped all the B vits but my E2 still went from 40 down to 21 within 3 weeks… Have no idea why this is happening, this negatively affects my erections…
I spoke to my TRT doc about it. He said generally carbohydrates and alcohol brings E2 levels up, besides Testosterone. Actually I did cut some carbs trying to loose weight, my beer consumption also fluctuates so there’s a chance it affects my E2. Did anyone notice a correlation between carbs/alcohol and E2 levels???
ncsugrad2002 and everybody else who’s E2 went down: have you cut carbs/alcohol?
Anything is possible, but I’m not sure where you would get E2 exactly. Getting fat and having E2 are not the same thing, and E2 is generated where you need it when you need it, so serum test saren’t even that great of a way to know what your E2 really is.
Lovely, my first doc said the same thing about testosterone. Homeostasis is a wonderful thing - but understand its broken in everyone here hence the need to fiddle with hormones.