The thing with compound movements that allow for very heavy loads is that sometimes the target muscle is not stressed as much as it could be. For example: I can do RDLs with over 350 pounds for 6-8 reps but I choose not to. I feel my hamstrings working much more with around 315 (current working weight for the last two sets). My lower back is a strong point so I have to make an effort not to let it take over on a movement that I am doing for my hamstrings.
I guess I do them a bit differently than the others. I do them from a platform about 4" off the ground. The bar stops at my feet and only clears my knees by a few inches.
4-5 sets for 8 reps works well for me. Just keep your scapulae pulled together and there shouldn’t be any problem with going heavy.