Hey guys, I have some questions on this topic. I will try to be concrete with my questions and try to ask them correctly. (Please understand that English is not my native language.)
On a side note: I’m asking for possible future information, not because I’m experiencing sides right now, however I did on previous cycle. As for now I’m clean and happy with it.
High Blood pressure during cycle/TRT or B&C is caused by high RBC, this causes the blood thickening and circulatory system must pump that thick blood harder which causes high BP.
Also water retention can cause BP to increase? Solution: don’t let RBC count get very high by donating blood every 60-90 days and monitor BP? Also make your cycles/blasts shorter?
Out of range estrogen also can cause high BP because of water retention? Solution: control estrogen to be in range (20-30 for most men)?
Acne is caused by overproduction of oil which is caused by excess of androgen hormones?
Elevated estrogen it is unknown whether it causes acne or not, some believe it does
but it’s more or less anecdotal? Solution: low dose accutane/isotretinoin cycle ~6 weeks (10-20mg daily or eod) and again control the estrogen?
Bonus question: proteinuria caused by high BP, can it be reversed assuming the cause (BP) is eliminated?
HBP is caused by excess sodium retention (11 HSD inhibition, other mechanisms) aside from that, the exact mechanism behind androgen induced increase in BP is unknown.
No, estrogen should be kept within adequate range based in proportion to androgen concentrations. Estrogen is very important with regard to maintaining neurotransmitter balance, increasing NO production (which aids in vasodilation), cholesterol and glucose management, maintaining and increasing BMD. The 20-30 optimum range is BS, even non aromatising androgens can cause water retention, look at methasterone and methylstenbolone. Yes, estrogen can increase bloating especially in areas around the face which reduces overall aesthetics, however dietary modification can reduce a fair bit of bloat, furthermore many issues with estrogen are linked to impaired hepatic function, as the liver is responsible for the clearance of excess hormonal buildup.
Acne is caused by increased sebum production, hypertrophy of the sebaceous glands is caused primarily by compounds with affinity to 5-a reductase enzyme or compounds with high levels of androgenicity (cough, tren cough cough). T-bol isn’t well known for causing acne, no affinity to 5AR and low androgenicity.
Depends if there’s significant damage to the kidney or not. If there is then no. You do know intensive exercise can lead to a false positive for proteinuria right?
You should be more worried about the cardiovascular complications stemming from HBP, high blood pressure is no joke, don’t mess around with it
Thank you, as always quality response. But I do have some questions.
How can high BP be prevented on cycle or blast? Assuming not high dosages are taken
(600mg testosterone enanthate), BP monitored and diet in check, but eating moderate excess of calories to gain muscle.
I don’t really understand estrogen should be based in proportion to androgen concentrations part. Like is there a reference on T to E ratio, for example 2500ng/dl testosterone, so where should estrogen be at?
I don’t think there is significant damage to my kidneys, however there is foam in urine all the time, aside from that maybe a bit more frequent urination. Reading on google made me think I have kidney failure or focal segmental glomerulosclerosis, which I don’t believe judging by other symptoms. I will do tests to check it just in case once I’m back and have free time (due to my profession).