Bill, I know you probably don’t have a high opinion of transdermal when injecting is more efficient but here goes: Do you think (discussing Fina) Phlojel is as effective as DMSO? I’ve used both and in the first week of my new cycle, using Phlojel, it seems to have less of an immediate effect than did the DMSO cycle. Thanks for any help or opinions you can give regarding transdermal delivery.
Bump this for info
Let’s bump this again! Any ideas Bill?
By the way, started putting a little DMSO (I hate that shit) over the area I applied with Phlojel (after it dried) and have noticed some difference. Of course it could be a coincidence and just related to the fact I’ve had Tren in my system for a week.
Another question when you have time: Does Tren, despite the short half-life build up in your system? Would there be a cumulative effect over time that would occur as far as blood levels?
I don’t have the information on how Phlojel
compares to DMSO for this purpose.
In the usual transdermal situation, steroid
esters after passing through the skin come
through as the free steroid, the ester group
having been cleaved by enzymes in the skin.
Whether this also occurs with DMSO or Phlojel
use, I don’t know. It’s possible that the
large amount of steroid per unit area overwhelms the amount of enzyme available, or possible that the DMSO interferes with the enzyme acting properly. It’s also possible that the cleavage does occur. So I don’t know
if levels can build up in the body as the ester or not.
Also, it’s not clear to me that what happens
isn’t that the TA, upon entering the aqueous
regions of the skin where the DMSO is then diluted, doesn’t just “oil out” in lymphatic and blood vessels, and mostly get wasted, taken up quickly by the liver (just as injecting straight into a vein or artery mostly wastes the steroid.)
Thanks for the expert opinion! I’m not sure either how effect these are, I think transdermal delivery has a great deal of promise considering the success of Androsol & the differen’t Fina transdermal concoctions (all of which have appeared to work to some degree). I know you weren’t very excited about this when asked in the past but what do you think of adding Isopropryl Myristate on the area of skin first, let dry, than apply other transdermal methods - ie Phlojel/DMSO/etc - of course I’m referring to applying Fina only as Androsol doesn’t need any help in doing it’s job.
The IPM would be useless as a penetration
enhancer in the treatment modality you describe. The way IPM works as a penetration
enahncer, when it does work, is when a relatively large amount (at least a substantial
film) of IPM is in place for a substantial
length of time and draws out endogenous skin lipids from the stratum corneum, increasing its permeability (and damaging and irritating the skin.) This is a slow process. For example, in
the experiments we do with mice, even at the 48 hour point the penetration enhancement effect
is nowhere near complete.
Applying IPM briefly before applying DMSO could
not be expected to accomplish anything.
Applying IPM after applying DMSO/Fina could
have a beneficial moisturizing effect though,
provided the amount of IPM was small and did
not leave a film on the skin once removed.
But that would much better be done with
a cream preparation rather than straight IPM
itself.