Hey gang. I’m wondering if Proviron can be used as an AI? I dont have out of range E2, but I have some Proviron on hand and thought maybe it could be used as an AI so I dont have to buy some. Any thoughts on this.
Love the knowledge here, Im eternally grateful for you all.
The New England Journal of Medicine says estrogen may be the main benefit of TRT, and you want to lower a “normal” estrogen level?
Estrogen is responsible for libido, fat loss, strong bones, etc.
As far as out of range estrogen →
https://journals.sagepub.com/doi/10.1177/1557988314539000
Our study did not link high estradiol levels with diminished sexual performance. Paradoxically, patients with low estradiol below 42.6 pg/ml had more patients complaining of low libido as defined by ICD-9 of 799.81 in the problem list. Patients with higher estradiol levels above 42.6 pg/ml had less sexual dysfunction problems identified by their providers. Of those that providers had identified as having low libido, 2,726 of 7,332 patients (31%) had higher estradiol levels and 4,606 patients (69%) had normal estradiol levels.
You should really have a proper AI on hand if your estrogen gets out of control and not rely solely on proviron.
This is what I found Bill Roberts has to say on Proviron as an AI:
Proviron (mesterolone) is an interesting anabolic steroid, though it is not of much value to bodybuilding. It seems that the most common reason for many to consider including it in a steroid stack is for anti-estrogenic activity. In the days before anti-aromatases and the use of SERMs (selective estrogen receptor modulators) such as Clomid and Nolvadex, there was some merit to this.
An amount of aromatizing steroid marginally over the amount that would be tolerable without Proviron became tolerable with the inclusion of it. However, the effect is indeed only marginal, and much better anti-estrogenic agents now exist. When these are used, there is no need for Proviron as an anti-estrogen.
The mechanism by which it has some effectiveness in this regard is from binding weakly to the estrogen receptor without activating it, and to the aromatase enzyme. In the first case, this partially reduces the number of receptor sites momentarily available to bind estrogen, thus reducing estrogenic activity. In the second case, some fraction of aromatase molecules at any given moment are unavailable to bind and convert testosterone, their binding sites being occupied with mesterolone.
Are you talking about TRT or a cycle?
I wouldn’t go that route personally. If your E2 is in range, I really doubt you are having issues. If it is pretty high, and you have high E2 symptoms, I’d rather figure out a low dose of an AI to figure out how little I could use to not have symptoms. For me, a tiny bit goes a long way.
If high E2 symptoms are suspected, first try a water pill to rule out testosterone’s influence on aldosterone, which changes the way kidneys re-absorb sodium and therefore water.
Believe it or not, fluid retention mimics symptoms of what people believe are high estrogen, bloating, anxiety and ED.
Great info. Thanks. I’ve heard this before and I’m happy to keep my E2 in the high range. Im not having negative symptoms at all. Should have mentioned that.
Thanks for this. I’m curious, if mest has the dual function of decreasing E2 and increasing Free T, why isnt it a better choice than an AI? If mest only marginally limits estrogen and I want to keep my E2 at the higher end of the range, then it seems a better choice for not crashing E2.
Ya, I’m not having issues with E2. My reading is higher end 40 pg/mL, but like syslord indicated, Im happy to keep it high for sex function, etc reasons. I’m just curious if i should get an AI, to keep on hand, in case E2 starts to fly, or if i can take proviron in that case, which i already have.
Thanks. No neg. symptoms to speak of at 200ml/wk, e3d, TT 997 ng/dL at trough, E2 40 pg/mL. Prolactin 13.
You’ll be happy to know I took ur advise and I started taking iron and TT rose from 605 to 997 over 4 months without having to up my Test dose much. Could be other factors, but thats the only change I really made. Amazing.
How long have you been on Testosterone? Why do you think E2 will start to rise? I am guessing if you have been stable for awhile, and on a set protocol, I don’t see the probability of E2 going up significantly as very likely. Getting a small amount of Adex isn’t a terrible idea. Just be careful. Adex is strong stuff. I trust myself to use it, but I have experimented with it and gotten blood work, so I know what X amount does to my E2.
I’ve been on for 10 months. E2 has been 60pg/mL to 48pg/mL to 40pg/mL… so going down… probably as i get leaner and i changed diet significantly and commited more to jiu jitsu training.
As an AI it has mild activity, but the lowering of SHBG could be a problem.
Read an old post of you, you still think clomid is bad?
I dislike toxins, chemicals, I want to be as natural as possible. With drugs there’s always side effects to benefit ratio, it fixes one problem, creating others. If you’re not past the point of no return, TRT will provide only benefits and no side effects.
I think TRT is to optimal therapy, treats multiple disease processes and the most natural treatment you could ever be on.
TRT is king of efficiency, as well as having a high satisfaction rate.