I was just reading comments on a FB page about preloading syringes and the risk of rubber leaching from the stopper into the the test. I’ve preloaded my entire time on TRT and loaded up two weeks worth of shots (eod) that I then place in my bedside drawer for use as needed.
Anyone else do this? Anyone know if there’s a real risk associated with doing so?
I do not, but some do.
It has happened so I suppose the risk is real. There is also a risk you could be struck by lightning today.
I think if you pay attention you will be fine.
A thing a friend of mine is doing - he transfers the ampule contents into a multidose vial just because of that risk
I’m fixing to switch my TRT protocol to twice a week vs my current once weekly and had planned on loading a months worth of shots at a time. Good time for this thread to pop up!
Wait what? Rubber is leaching into the test?
And if it does happen , what do you think would be the outcome?
I would be more worried about UFO’s coming. Its oil suspension, not alcohol. People just have too much time on their hands so they invent stuff to frighten people. It’s a thing now, the existence of Fox News proves my point.
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I saw it in CNN first lol
Fake news bro. Fake news
Way off topic, but I just wanted to clarify I don’t watch the news, from any source. I just saw it as one of their headlines before anybody else.
Doesn’t take long to load a syringe and shoot.
I find it
Funny ppl are really loading up a months worth of
Shots like it’s some
Crazy long process. Less time
Than brushing your teeth.
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I load up a few weeks at a time. But I can only get glass amps, so I have no choice but to load at least a few. Can’t leave it laying about in an open amp.
I typed the craziest thing I could think of, and behold!
I would feel more comfortable to transfer the ampules to multidose vials. Seems more safe to me.
@highpull @hardartery @dextermorgan @oz_dude
Extractable and leachable studies are an essential part of every prefilled syringe presentation seeking for approval and marketing authorization.
Especially insuline syringes are designed for formulations on an aqueous (water) basis and not for formulations containing oil (such as your T). For example these syringes frequently contain silicon oil to reduce gliding force. Every hydrophobil (oil) will extract this oil from the syringe.
You are right that alcohols such as methanol or ethanol are the best substances when it comes to the extraction ‘power’ of substances from the syringe. This is simply because these chemicals have a high solubility of hydrophilic (watersoluble) and hydrophobic (soluble in oil) substances.
Anyhow the oil in your T formulation will extract every hydrophobic chemical from the parts of the syringe to which it gets in contact with. The kinetics is determined by factors such as length of exposure, temperature and also light intensity.
Its impossible to say whether your exact syringe and the storage condition will result in relevant (toxic) levels of chemicals to be extracted but I recommend to keep the time that the T sits in the syringe to a minimum.
Testosterone is also light sensitive, thats why the primary package (vial or ampulle) is brownish and not clear.
I headed an extractable and leachable lab in pharma for some years and you wont believe what you find when you do this.
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Interesting, I know a few guys who get their testosterone shipped to them in preloaded syringes. I don’t understand the clinic/pharmacy rationale for doing that.
Money. I guess the price per mg T is higher then. But this is only speculation.
But i know that its common practice in the US that the content of single use vials intended for one patient is split into two or more syringes for two or more applications.
Eylea (a biologic for certain eye disease injected into the eye) for example comes in a single dose vials. Volume is 50ul per dose but the vial contains enough overfill to get 4 syringes a 50ul out of it. The clinic than charges 4x the costs of equivalent of 1 vial. Its off label but increases profit.
The tricky part is the legal aspect. In the Eylea example the product comes with only 1 syringe which is designed and tested for the product. The product is highly sensitive to aggregation and your Eyes are very sensitive to product aggregates. If patients suffer from this practice of aliquoting into non tested syringers then is the health care provider/clinic liability because of off label usage.
I would agree that the risks from prefilling T is low, but if you can avoid this unknown easily than thats worth the little effort.
The amps are clear, I have never had one that isn’t. Overblown problem invented by nervous people who enjoy worry.
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I give you the perspective of a biochemist with 12 years experience in drug discovery and research. You are free to do with it whatever you like.
In the US the vial is clear but prescribing info reads:
Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Protect from light.
On the carton you can read in bold:
Store product in the carton to protect
contents from light.
I’m not in the US, just offering that the amps have always been clear, not brown as you posited. I am sure in some places they are in tinted glass, as B12 is. The test is also never at less than 85 F here. Ever. That’s the normal temperature, not a hot day but in the winter. Could there be some leaching? Maybe, but I doubt it’s of any significance unless people are storing prefilled syringes for years at a time.