As a chemist who did that type of analysis for some years professionally I respectfully disagree. There is a reason why prefilled syringes are mostly made of glass and not of cheap polymers like for example disposable insulin syringes are made of. Especially when its a formulation based on oil.
Storing T in a cheap disposable syringe for weeks at the conditions you describe might set you up for troubles long term.
I would not feel comfortable as I have seen enough highly toxic substances leaching out of ‘cheap plastic’ syringes within weeks at 30°C.
We did a study with syringes from a ‘cost efficient’ supplier located in asia. Extractables studies identified more then a dozen really nasty hydrophobic chemicals above the NOEL level, conditions were accelerated conditions at 40°C using isopropanol as solvent for 6 months. Thats not too far away from storing a oily solution for a couple of weeks at the temperatures you are living at.
What about hours? I prefill for at most 12 hours. Is that an issue?
I would not equate isopropanol for 6 months with vegetable oil for less than 6 weeks, but you go ahead. I will repeat myself, an overblown worry for the anxious at heart.
Its the difference between science based and emotion based decission making rather then anxiety. But fair enough.
Many toxic chemicals have higher solubility in lipids then in eg isopropanol. Whether the oil is plant based or not doesnt play any role. And the main problem with these lipophilic substances is that they accumulate in your fat tissue.
And below the degradation kinetics of T exposed to natural light.
There is a saying among Health Care Professionals and Drug Developer that the biggest risk during therapy is the patient because they think that they know everything better.
I am confident that it does not compare in any way to what we get from the plastic in plumbing systems, in the coffee coming from plastic coffee makers, and a myriad of other sources that are around us. Sure, ideally everyone would use a glass syringe and not store things, and we would eliminate plastic altogether from the world. Realistically, what is likely to leech out of the rubber on the plunger is at best negligible and not going to cause anyone any actual harm. It’s overblown worry for people that like to be anxious.
When it says “iradiation time” is that just exposing to normal light or something stronger to speed things up?
Agreed. But keep in mind the different routes of application. Orally ingested substances have a much lower bioavailability then when im or subq applied. Calculating the NOEL (no observed effect level) for many toxic substances typically uses a factor of 100 between oral and im/subq/iv.
An extrem example is elemental mercury. Eat a couple of grams and you wont feel anything. Inject or breath some half a gram and you gonna suffer big time.
But again i respect your opinion.
Normal day light (ncluding exposure to sun light).
Interesting. I’m really surprised it degrades that quickly. Good to know though.
Yes, but keep in mind that day light can provide between 10000 and 120000 lux. In a normal room you might have 500 lux. The message is, T is photosensitive therefore keep it protected from light during storage as stated on the carton.