Not sure if this belongs here, but have any of you guys had the DNA test for pharmaceutical issues? I just had it done, and discovered that I have issues with tons of meds, that thankfully, I haven’t tried. And I found out why codeine has no effect on me.
I have never even heard of this but that sounds really interesting. Can you give any more details on it, such as what it is, what it costs, what it tests for? Thanks
I got it through a company called GeneSight Psychotropic. I’ve got a shrink for ADD recently, just to see what’s changed both in me and in treatment. He wanted this right off the bat before considering any srcips or anythin. The company started off dealing with MTHFR stuff but is now doing a “Combinatorial Pharmacogenomic Test”. It is apparently usually covered by insurance, but they have pragrams to cut cost as well, and I think it’s only $300 anyway. I found out all kinds of stuff based on my genome. Like antipsychotics wouldn’t do anything to me either, and SSRI’s would be a really huge mistake.
That looks interesting. I don’t really take prescription meds at all, other than albuterol as needed. It would be really cool if someone designed something like this for AAS.
It should have an effect as a cough suppressant but shouldn’t work as a pain medication if my assumption is correct that you’re a CYP2D6 poor metabolizer.
Pharmacogenomic testing will in the future be a very valuable tool but at the moment it’s not advanced enough. From over 200000 drugs in Germany only 40 need a genomic test beforehand to minimize risk. That doesn’t mean the information is not valuable you’re getting now. Metabolism is in my opinion one of the most important aspects of drug use.
But the information is severely lacking. The research isn’t advanced enough to predict too many things. We don’t know which receptor mutations cause what or even which genes affect which disease oftentimes. That will take a long time till we get there.
What I’m saying is, take this test for what it’s worth. It gives you important information on your body but it won’t explain your body to you.
What would be the basis for these assumptions?
I am a hypermetabolizer of antipsychotics. Which would be exacerbated by eating grilled foods or smoking, apparently. I know that they don’t work on my brother, now I know why. SSRI’s would accumulate in my system and quickly achieve a toxic level, so they say. The test encompasses not only CYP’s but also some transport systems like UGT2B15. The ones that are somewhat researched as of right now are in my report, with a comprehensive list of drugs that would specifically be affected by my genomic makeup. I am weird enough that the lab has requested an interview with me for research. Several of my lists are the polar opposite of most of the population, and very unique. I’m sure that will change over time as more people are tested, but right now I’m an outlier genetically.
It doesn’t work as a pain med for me at all, and the results break down several sub-types of CYP2D6. Some of mine are normal, some are not. The test was really mostly to find out that bit, I have a stupid tolerance for things like Adderall, but it seems that those drugs are actually a bad idea for me and my ADD anyway.
cyp2d6 polymorphism, you’re probably a poor cyp2d6 metaboliser, thus you don’t convert enough codeine to morphine. I’m the opposite (ultra-rapid). I need to be careful if taking antitussives and/or painkillers containing codeine.
So you are a CYP1A2 extensive metabolizer which isn’t a polymorphism which means its rare. But beware, that doesn’t hold up for all antipsychotics.
Yes UGTs have great variation too, but only a few are relevant in a few cases.
Why wouldn’t it work as a cough suppressant? Do you have a mutation in your opioid receptors in the cough center of your brain? Note that the active compound for cough suppression IS CODEINE so it doesn’t matter how you metabolize it. For pain it’s the active metabolite morphine which in many people (>1% of the population) doesn’t work for this reason.
I don’t say the test is not worth the money. I’m just underwhelmed by the things I could learn by doing it. If I’d do it, I’d wanna know which receptor has which mutation which causes me to be prone to X.
Still, if you’re a real outlier, the test was good for you. You can make your own conclusions now which steroids to use at which doses (half true, dynamics are missing) which gives you an edge.
Edit: same holds true for SSRIs, they are all different and not metabolized by the same enzymes, so don’t think every SSRI would be a “huge mistake” if you need one, I hope you never will but still.
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I don’t know if it does or doesn’t, I never had it for cough, I’ve never had cough as an issue that required medication. Insurance covers the test, so cost isn’t a factor.
That’s actually quite nice. You now know Clopidogrel probably won’t work for you and the serotonin transporter read is very nice. You really are ill equipped for a lot of anti depressants. Reduced metabolism combined with reduced response in some cases. There a still a lot of options left.
The most common reason to get a prescription for codeine is for severe cases of dry cough that’s why it is important in regard to the compound.
I had a bottle of liquid codeine after my tonsillectomy when I was 16. I started at the bottle dose, did zero. I took more. Zero. I finally turned the bottle up and chugged it. All I got was relief for a minute or so because it coated my throat. I had assumed that Tylenol with codeine didn’t work because I didn’t take enough of them, but now I have a reason.
Haha nice story, we often learn through trial and error
Guess you had to eat more ice cream then
Fudgesicles are king for this. Just sayin…