On TRT - Testosterone Drop after Reducing SSRI's?

Pharma TRT
1

Hi All,

I was wondering if anyone who has come off of SSRI’s aftering starting/being on TRT for a while and noticed that their testosterone levels dropped as they reduced the levels down?

I’ve been on a stable dose of 85mg E4D with 0.25mg Anastrazole E12D which has kept everything nicely in range.

However, I’ve been titrating my Sertraline down as I don’t feel like I need it anymore. This was all going fine - I’d gone from 150mg ED to 50mg ED. Then when I dropped to 25mg ED I started to feel slower/tired/hungry. I left this for a while before getting a blood test, but then went and got one. What it showed was my testosterone levels had dropped approx 33%, everything else was exactly where it should be (E2, SHBG, Free Test etc) but for some reason, my levels had dropped from around 30nm/dl to 22nm/dl.

Initially, I thought this was just an odd one off result - so left it another 6 weeks - continued my usual regime and tested again - same result.

I’ve now increased to 100mg E4D from 85mg and after my 3rd injection I am now feeling more like myself again.

So - my question is, has anyone else had anything like this happen? No changes in dose and no changes in anything other than reducing SSRI’s…?

2

There is no connection to stopping your SSRI and decreasing testosterone.

TRT is not a set and forget therapy.

This happens quite frequently to some men on TRT who aren’t on SSRI’s.

3

Thanks - I just found it odd that it started to drop off. I get that it’s not a set and forget, but it just seemed an odd co-incidence that it would drop. Shame there’s no quick and easy way to test daily! Would love to have that level of data!

Now that I’m back to how I was before, I can pinpoint when I last felt “good”/like this and that was just before I came down with COVID…

4

Given the half-lives of cypionate, testing testosterone daily is pointless as is takes about 4 weeks to start seeing changes in levels.

5

I have a somewhat similar issue since dropping clonazepam completely after a long taper. I’m currently off trt 16 weeks now, but I went from having energy and feeling physically good to having super dry popping joints and fatigue after stopping. Almost like my T and or E just plummeted.

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6

I had the same symptoms, only they never went away even after more than 2 years.

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