Newbie 57 Y/O Starting Test C Need Advice on TX and Protocol

Pharma TRT
41

Thanks,
I am pretty sure I was having symptoms of high E2. Very Bitchy, nipples hard, water retention in hands, feet, and shins.

I started back with .1 mg of anastrozole 2 x per week. My old dose was .2mg.

I think I will check my levels with both methods in 2 weeks. I am already feeling a bit better after 2 doses, my third being this evening.

Thanks

42

Guys,
I left my HCG out overnight for about 12-16 hours. I forgot to place it back into the fridge.
Is that long enough to ruin it?

43

Should be fine. May have lost some potency. The refrigeration slows down it losing itā€™s potency.

44

Good idea, let us know what you find out.

45

So,
3 months ago I stopped my AI ( was taking .25 2x/week) cause my E2 crashed to below 5,
then after a month(2 months ago) my numbers were:Testosterone, Serum 618 ng/dL (264-916)
Free Testosterone(Direct) 15.2 pg/mL ( 7.2-24.0)
DHEA-Sulfate 34.7 Low ug/dL (48.9-344.2 CB )
Estradiol 45.7 High pg/mL (7.6-42.6) CB Roche ECLIA methodology
Prostate Specific Ag, Serum 1.4 ng/mL (0.0-4.0 ) CB Roche ECLIA methodology.

So I started back on AI at .1 2x/week( along with my normal HCG 350 2x/week and TestC 30 2x/week.)

Now after about 2 months, I started having painful bumps under my left nipple, with some hand swelling and foot bones popping. I assumed my E2 was getting high causing Gyno, so I got tested in the afternoon anout 28 hours after my last dose series (I take all 3 drugs together) 2x/week
but my E2 was only 13.6 (7.6-64.6)
free T 13.1 (7-24)
Total T 619 ( 264-916)
DHEA 35 (48-344)

I am really confused why I am getting hard nipples with painful nodules and hand/foot swelling if my E2 is not high. Should I trust this lab? I usually test in the am 36 hours after my last evening dose?
Could have sworn my E2 was high, what do you guys think?

46

Guys,
Can anyone please help out with questions from my last post above. I am really confused about my next step.

47

I would double test, your numbers are too low at 28 hours post injection. I would also d/c the anastrozole. Get the next labs done at trough.

48

Last time I stopped my AI, my E2 got up to 45 and I was really bitchy with some gyno. So I started back on it.

49

I was concerned with your extremity symptoms, especially the popping. I wasnā€™t sure what to make of your lab results with blood drawn so close to dosing. Figured it best to start from scratch and see where the labs are a trough. Regardless, your test numbers should be higher so close to injections. I understand some are sensitive to E2, and you may be one of them, so I can see why youā€™d want to stay with anastrozole. Iā€™d at least up the test.

50

Thanks,
I reduced my testosterone dosage from Test C 50 twice a week to 30, because my HCT got up to 53. Also it felt like my chest/heart was racing. I have had four blood clots in the past and donā€™t want to risk having more clots and donā€™t want to give blood that frequently.
I will recheck my labs in a couple wks and see if my E2 is ok.

51

Damn, what is/was your platelet count?

52

Act.was actually 53.8.
Platelets about 193.
I really am trying to grey this fine tuned,
But when my E2 gets high I get gyno and bitchy, if it gets low I get tired and flat feeling.
Just worried that I got html when E2 was 15, if it actually was that number.

53

Highpull,
Can I ask, what lab brand do you use? I have been using Labcorp thru Life Extension.
I was wondering if I should try a different lab.

54

I think I am getting my regimen better tuned.
Changed my doses to:

TestC 40 SubQ 2x / week Sunday am and Wed eve
HCG 333u 2x / week Sun/Wed
Amidex .15 mg 2x/week Sun/Wed

Got labs from Labcore at 8 am Friday last week:

Total Test 841
Free T 18.3
DHEA 34 - low
Estradiol 28 (7-42)
Estradiol Sensitive 16 (8-35)

Vit D 28 -low even after 4 trips to Florida this winter( one last week before test)

I am feeling pretty good. Sleeping well with nighttime erections, Lidido decent, No Gyno, Just some mild fluid retention in ankles/joints.
Energy level is good.

Thanks for any input.

55

Your sensitive E2 is on the low side, I might expect lower libido than usual, you say yours is decent which suggest youā€™ve experienced better. Another case where the sensitive E2 is showing itā€™s strengths and accuracy.

Iā€™m not a fan of the Roche ECLIA methodology E2 testing as I see it overstate E2 often, I would reduce the AI slightly. You need to add 50mg DHEA daily to your TRT protocol which should increase E2 slightly, if you choose to supplement DHEA, you could keep the AI dosing unchanged. You also need to supplement some Vit D.

56

So you are trusting the sensitive test more? (Done by liquid chromatography)
What are the downsides of taking DHEA?
I will either decrease my AI slightly or start DHEA. I need to read about the risks/rewards.
I tend to buy vitamins, but donā€™t stick to taking them. Would be easier to adjust my AI.
I will start Vit D as it has been low in the past.

57

You need DHEA, DHEA is an important hormone. The risk is doing nothing if youā€™re deficient.

58

Sorry, I must have missed this. Quest

59

Feeling pretty good? Iā€™d leave it alone, wouldnā€™t focus on the numbers without obvious symptoms. LC/MS/MS methodology is known to be inconsistent. Add DHEA and VitD.

60

Thanks so much for your help.
I wonder why my DHEA is low?