Hi guys I’m new here after spending hours looking at posts.
I’m 30 and have been diagnosed with Hypogonadism.
My last 3 test results have been below 7n/mol.
I got started on TRT 4 weeks ago with the standard Nebido protocol, shot then 6 week booster then 12 there after.
So I’m 4 weeks in and have had a few weeks of feeling great, this week though I’ve felt so tired and felt like I’ve crashed, is this normal?
I’m so worried and confused but a few people have said that it takes time to build up in the system and I’ll be ok?
I just don’t want to keep crashing regularly on treatment and as I’ve just started I’m very concerned. Any advice is welcomed, thank you.
I’m afraid it will take a little longer to build up the half lives in your system, it could take a month or a little longer where with sustanon or enanthate would take 6 weeks.
Your natural production is more than likely shut down and now all you have in your system is Nebido which hasn’t had enough time to build up in your system. The first 4 weeks you have your natural production on top of the Nebido where now all you have is the Nebido which is low.
The half life of cypionate is 7-8 days, so 40 days until levels are stable, Nebido has a half life on paper of 90 days, but in studies it shows to have a half life of 21-23 days. An injection duration of 6-8 weeks was found to by optimal for replacing T with Nebido.
The take away from this is no different than if you were on a shorter half life, you would still experience a similar effect at about this time, a shorter half life would have probably shut you down sooner.
Hang in there and give it more time.
A pharmacokinetic study of injectable testosterone undecanoate in hypogonadal men.
The 500-mg dose, when given as the second injection, yielded optimal pharmacokinetics (defined as mean peak T values not exceeding the normal range and persistence of normal levels for at least 7 weeks), suggesting that repeated injections of 500 mg at 6-8-week intervals may provide optimal T replacement. The mean serum levels of estradiol were normalized following the injections, and prolactin levels were normal throughout the study. Significant decrease of serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels was observed, with the decrease in LH levels being more pronounced.