Looking for Solution

Pharma TRT
1

Hello All
I just signed up fpr membership thanks for having me and the price is great I would call myself a senior lifter I am 50 look about 35 good genes maybe hard work outs for sure. Have been all over the world ( ask me about Turkey Tonga Russia France Spain Greece China India Thailand Caribbean etc )

I love to travel and consider myself to be an expert at finding super priced plane tickets and places to stay for almost free I recently went to China for $200 round trip from LA and stayed a month spent less than a grand total cost I went out every night came home with a new girl as often as I liked (every night)ate good and saw all the sites. Really have had the travel bug for ever so anyone needs tips on were to go how to get there and do it on budget ask me.

To health I keep fit with 3 days aerobic 3 days weights lift heavy low reps cardio 25 minutes maintaining about 85 to 90% of max for age 150 bbm to 165 bbm for duration. I am 5’10 and 170 12.5% body fat. Have used hgh with little effect in 1996 for a year straight was somewhat disappointed although I did notice a massive increase in tolerance and recovery to alcohol and general partying, other than that not much.

Short cycles with Test Deca and anti estrogens here and there with results good and bad last cycle 2004. I consider myself lucky recently went to see a trt doctor that wrote a book called the male andropause. I had bloodwork and have high total test 779 or conversion 27 for any age but low %free test at 1.19 and high t3 uptake@39 unexplained.

I have no explanation why I have high shbg and high cortisol and elevated t3 uptake I have to shake this as it has knocked my dick in the dirt and if anyone has experienced this it is brutal. The doctor said drink more water less alcohol sleep more and take fish oil, stinging nettle and eat broccoli vit c tea and magnesium. Have been doing these things but looking for as usual a quicker fix!? Thank you to anyone that has ideas or similar experiences that they solved

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Well shit. You originally posted this to SAMA. Now it makes a little more sense…

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[quote]T83 wrote:
Hello All
I just signed up fpr membership thanks for having me and the price is great I would call myself a senior lifter I am 50 look about 35 good genes maybe hard work outs for sure. Have been all over the world ( ask me about Turkey Tonga Russia France Spain Greece China India Thailand Caribbean etc )

I love to travel and consider myself to be an expert at finding super priced plane tickets and places to stay for almost free I recently went to China for $200 round trip from LA and stayed a month spent less than a grand total cost I went out every night came home with a new girl as often as I liked (every night)ate good and saw all the sites. Really have had the travel bug for ever so anyone needs tips on were to go how to get there and do it on budget ask me.

To health I keep fit with 3 days aerobic 3 days weights lift heavy low reps cardio 25 minutes maintaining about 85 to 90% of max for age 150 bbm to 165 bbm for duration. I am 5’10 and 170 12.5% body fat. Have used hgh with little effect in 1996 for a year straight was somewhat disappointed although I did notice a massive increase in tolerance and recovery to alcohol and general partying, other than that not much.

Short cycles with Test Deca and anti estrogens here and there with results good and bad last cycle 2004. I consider myself lucky recently went to see a trt doctor that wrote a book called the male andropause. I had bloodwork and have high total test 779 or conversion 27 for any age but low %free test at 1.19 and high t3 uptake@39 unexplained.

I have no explanation why I have high shbg and high cortisol and elevated t3 uptake I have to shake this as it has knocked my dick in the dirt and if anyone has experienced this it is brutal. The doctor said drink more water less alcohol sleep more and take fish oil, stinging nettle and eat broccoli vit c tea and magnesium. Have been doing these things but looking for as usual a quicker fix!? Thank you to anyone that has ideas or similar experiences that they solved [/quote]

may be it was something in the food that you ate…
I would suspect thyroid imbalnace or malfunctinoing liver.

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Remember, using punctuation can be fun!

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I am looking for solution and the food idea never crossed my mind not sure where to start. The imbalance of the thyroid or liver problem will check it out with doctor. I did a ton of blood work already and liver bun creatine etc looked good
Thanks

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Do the male lab panel at LEF.org
Vitamins and Supplements Rooted in Science - Life Extension
You will have to pay out of pocket. Cheaper to get a membership then order.

When you get results, we can tell you what your next steps are.

Sounds like you may have elevated E2. Factors include waist size, height, %BF, where you carry fat, BP, cholesterol, several nutritional issues, fasting serum glucose

Read the stickies.

If your doc is so great, you must have more lab results.

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your right a lot of lab work here is a scan of it and the Doctors advise

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[quote]T83 wrote:
The doctor said drink more water less alcohol sleep more and take fish oil, stinging nettle and eat broccoli vit c tea and magnesium. Have been doing these things but looking for as usual a quicker fix!? Thank you to anyone that has ideas or similar experiences that they solved [/quote]

Before I stopped drinking and got my diet in order, I was a mess. There are no “quick fixes” for this.

10

Pc dude, I appreciate the advise. I just feel like I fell of a bridge and I have always and still am balanced out pretty good. I eat, work, workout etc. about the same as I ever did. I did have a look at my Labs and E2 is 37, cortisol and shbg is high too. I posted Labs last night as attachment with Doctors advise but I don’t see them today. I wrote to foreman for advise as to why they did not show waiting reply. I hope I can send all to group the Doctors write up and advise may help others too. He advised basically like you said give it time he urged me to sleep well, relax and drink water take supplements, eat broccoli etc. I looking at other posts and my labs see light at the end of the tunnel not sure yet but with my E at 37 and t at 789 and free at just 1.19% some l-dex maybe in order. Because right now I am so out of sorts I can hardly go a minute without feeling massive frustration and it is cutting into every aspect of life

Thank you Pc and everyone for the hand
Tom

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[quote]T83 wrote:
I am looking for solution and the food idea never crossed my mind not sure where to start. The imbalance of the thyroid or liver problem will check it out with doctor. I did a ton of blood work already and liver bun creatine etc looked good
Thanks[/quote]

90% of dr’s miss thyroid because they only look at 20% of the equation.

12

This is what doctor gave me he missed fsh test and i am going to get it otherwise preety complete package with advise it is a few pages I send all
Re: Your test results
Please fmd below and attached your lab and imaging results. Lab and imaging tests playa role in
your health care. But while they are important roles, in most cases these tests don’t provide all
the information your health care professional needs to make a diagnosis or treatment decisions.
As such, a follow up appointment with your health care professional is advised in order to
discuss and understand your results. This will then help you and your health care professional
discuss the next step in your diagnosis and treatment plan.
Comments on lab tests:

  1. High SHBG levels and this leads to:
  2. Low Free Testosterone levels, albeit your Total Testosterone is appropriate for
    age
  3. High Normal Cortisol level, indicative of High Stress
  4. Elevated T3 Uptake
    www.opalmedical.com
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Page 2 of5
Sex hormone-binding globulin (SHBG)
This is a glycoprotein that binds to sex hormones, specifically testosterone and estradiol. Other
~roi ormones such as progesterone,cortisol, and other corticosteroids are bound
( by transcortin.
Testosterone and estradiol circulate in the bloodstream, bound mostly to SHBG and to some
degree bound to serum albumin. Only a small fraction is unbound, or “free,” and thus
biologically active and able to enter a cell and activate its receptor. The SHBG inhibits the
function of these hormones. Thus bioavailability of sex hormones is influenced by the level of
SHBG. SHBG has a higher affmity for Dihydrotestosteronethan for Testosterone or
for Estradiol making it essential in women for regulating the bio-availability
of Dihydrotestosterone.
SHBG is produced most by the liver and is released into the bloodstream. Other sites that
produce SHBG include the brain, uterus, testes, and placenta. Testes-produced SHBG is
called androgen-binding prote0. The gene for SHBG is located onchromosome 17.
Conditions with low SHBG include polycystic ovary syndrome, diabetes, andhypothyroidism.
Conditions with high SHBG include pregnancy, hyperthyroidism, andanorexia nervosa. There
has recently been research to link high SHBG levels with breast and testicular cancer as well.
When determining levels of circulating estradiol or testosterone, either a total measurement
could be done that includes the “free” and the bound tractions, or only the “free” hormone could
be measured. A free androgen index expresses the ratio of testosterone to the sex hormone
binding globulin and can be used to summarize the activity of free testosterone.
Possible ways to lower SHBG:

  1. Drink more water.
  2. Lose weight - this decreases SHBG & losing abdominal fat reduces estrodiollevels …
  3. Reduce excessive alcohol consumption - this also decreases SHBG.
  4. Regular exercise. In one study men who walked daily were far less likely to develop
    _ prostate cancer.
    S. Eat adequate protein
  5. Urtica Urens/Stinging Nettle~
  6. Fish Oil (Omega 3) ~
    Also eat more cooked tomato which contains Iycopene which markedly reduces prostate
    cancer risk. Eat Cruciferous vegetables such as broccoli, cauliflower, cabbage, and b-russel ~routs. These contain Ind Carbinol which increases the conversion of estradiol to
    “weaker” (20HE) estrog . Broccoli also contains quercetin which is beneficial for chronic
    prostatitis.
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Page 3 of5
Cortisol
Cortisol, also known as hydrocortisone, is a corticosteroid hormone or glucocorticoidproduced
by the zona fasciculata of the adrenal cortex, which is one of the two parts oftheadrcnal poh … e",~
gland.ll ] It is released in response to stress, or to a low level of blood glucocorticoids. It is
controlled by hypothalamic secretion of corticotropin-releasing hormone (CRH), which in turn
triggers pituitary secretion of Adrenal Corticotrophic Hormone (ACTH); ACTH is carried by the
blood to the adrenal cortex where it triggers glucocorticoid secretion. Its primary functions are to
increase blood sugar and stores of sugar in the liver as glycogen, aid in fat, protein and
carbohydrate metabolism, and to suppress the immune system (and regulate lymphocytes).
Various synthetic forms of cortisol are used to treat a variety of different illnesses.
The amount of cortisol hormone present in the blood undergoes diurnal variation, with the
highest levels present in the early morning (approximately 8am), and the lowest levels present
around l2-4am, or 3-5 hours after the onset of sleep. Information about the light/dark cycle is
transmitted from the retina to the paired suprachiasmatic nuclei in the hypothalamus. The pattern
is not present at birth (estimates of when it starts vary from two weeks to 9 months).12]
Changed patterns of serum cortisol levels have been observed in connection with
abnormalACTH levels, clinical depression, psychological stress, and such physiological stressors
ashypoglycemia, illness, fever, trauma, surgery, fear, pain, physical exertion or extremes
oftemperature. Cortisol levels may also be different for people with autism or Asperger’s
syndrome.13]
There is also significant individual variation, although a given person tends to have consistent
rhythms.
Factors generally reducing cortisol levels
I. Magnesium supplementation decreases serum cortisol levels after aerobic exercise, but
… … . . — not m resistance trammg. JYJ Omega 3 fatty acids, in a dose dependent manner (but not significantly), can lower
cortisol release influenced by mental stress by suppressing the synthesis of interleukin-l
and 6 and enhance the synthesis of interleukin-2, where the former promote
higher CRHrelease. Omega 6 fatty acids, on the other hand, acts inversely on interleukin
synthesis.
3. Music therapy can reduce cortisol levels in certain situations.
4. Massage therapy can reduce cortisol.
5. Laughing and the experience of humour can lower cortisol levels.
6. One study by a Japanese cosmetics company has asserted that makeup reduces cortisol
___ levels in a mental stress situation .
…:=}. Soy derived Phosphatidylserine interacts with cortisol but the right dosage is still unclear.
8. Vitamin C may slightly blunt cortisol release in response to a mental stressor. IV] l.1 ( ·b’
9. Black tea may speed up recovery from a high cortisol condition.

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Page 4 of5
Factors generally increasing cortisol levels- A VOID
I. Caffeine may increase cortisol levels
2. Sleep deprivation increases cortisol levels.
~ lntense (high V02 max) or prolonged physical exercise stimulate cortisol release in order
~ to increase gluconeogenesis and maintain blood glucose. Proper nutrition and high-level
conditioning can help stabilize cortisol release.
4. ValNal variation of the BDNF gene in men, and the VallMet variation in women is
associated with increased salivary cortisol in a stressful situation.
5. Hypoestrogenism and melatonin supplementation increases cortisol levels in
postmenopausal women.
6. Burnout is associated with higher cortisol levels.
7. Severe trauma or stress events can elevate cortisol levels in the blood for prolonged
periods.
8. Subcutaneous adipose tissue regenerates cortisol from cortisone.
9. Anorexia nervosa may be associated with increased cortisollevels.1711
10. The serotonin receptor gene 5HTR2C is associated with increased cortisol production in
men.
II. Some formulations of combined oral contraceptive pills increase cortisol levels in young
women who perform whole-body resistance exercise training.
8 Commuting increases cortisol levels, related to the length of the trip, the amount of effort
_ involved and the predictability of the trip.

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T3 Uptake ,…—.
Page 5 of5
The Resin T3 Uptake is used to assess the binding capacity of the serum for thyroid hormone.
This is used to help determine if the Total T4 is reflecting the free T4, or if abnormalities in
binding capacity are responsible for changes in T4 values. This test is only useful in conjunction
with Total T4 or Total T3. In the Resin T3 Uptake test, labeled hormone is added to the patient’s
serum. If there is an increase in binding capacity, more labeled hormone will be bound to the
binding proteins and thus less will be left free in the serum. The free labeled hormone in the
serum is measured and usually reported as a percent of the total labeled hormone added.

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Need lab numbers, units and ranges, less talk.

You are not giving us enough information. Put lab work in a list, not hidden inside paragraphs.

Lets see that ton of lab work.

T is low and SHBG is high probably because of your E2=37. You are been told what to do about that. The only effective thing is anastrozole. Your liver may be unable to clear estrogens properly. This can be from alcohol or drugs, Rx and OTC, that compete for clearing.

Your travels may have exposed you to tropical diseases or parasites. You may also have a STD. Many things can lead to hormone imbalances and elevated cortisol. Recent vaccines can increase cortisol for a while.

A liver disease/parasite would increase E and cortisol.

Your TT is high in part because high SHBG leads to high amounts of SHBG bound T [SHBG-T], which is functionally inert. Liver problems could prevent proper SHBG-T clearance.

Your low T and high E2 are causing your libido problems and can cause many of the symptoms of hypogonadism.

Do you use iodized salt? You should. There is no iodine in sea salt unless added.
Do you get a lot of sun exposure? A darker complexion reduces one’s vit-D3 response to sunlight.

If your life style is not stressful, then you need to look at disease as a cause of increased cortisol. After a while, your adrenals can functionally collapse, then you are really incapacitated. You need to monitor DHEA-S as well.

How tall are you?
Waist size and how has this changed. What was your waist size when you were 25?
Any aches and pains? joints? muscles? guts?
Guts working normal?
Urine flow reduced?
Any rashes?
Head aches?
What drugs , alcohol, tobacco, Rx, OTC, recreational?
Do you use iodized salt and eat sea food?
Changes to skin, nails or hair?
Any sign of gyno?
Do you take vitamin D?
Do you take fish oil?
List herbs and supplements that you take - include herbal teas.
Do you have allergies and how has that changed?
Short tempered, frustrated, intolerant, noise now bothers you?
Exposure to workplace chemicals, metals, fire retardants, fumes?
Gum disease or inflammation?
Blood pressure?
High cholesterol? Using a statin drug? -What and how much.
What do you apply to your skin?
Healthy fats in diet?
How much soy in your diet?

What do you do for a living?
Work stress? Financial stress? Injuries? Job loss? Surgeries?

Some of your problems are not unusual for your age. Your high E high T is strange.

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test name in range out of range Reference Range
LIPID PANEL
CHOLESTEROL TOTAL 180 125-200 mg/dl
HDL 58 > OR = 40 mg
triglycerides 33 < 150 mg/dl
LDL-Cholesterol 115 > 130 mg/dl (calc)

 desirable range < 100 mg/dl for patients with CHD or
 diabetis and < 70 mg/dl for diabetic patients with
 known heart disease.

    CHOL/HDLC RATIO         3.1                                   < OR = 5.0 (calc)
    comprehensive metabolic
      panel W/ EGFR
      Glucose               89                                      65-99 mg/dl

                                                                 Fasting Reference interval
      UREA NITROGEN (BUN)   12                                     7-25 mg/dl
      CREATININE            1.09                                   .76-1.46 mg/dl
      eGFR                  >60                                    >60

      SODIUM                145                                    135-146 mmol/L
      POTASSIUM             4.3                                      3.5- 5.3 mmol/L
      CHLORIDE              109                                      98-110
      CARBON DIOXIDE        25                                       21-33 mmol/L
      CALCIUM               9.3                                      8.6-9.2 mg/dl
      PROTEIN, TOTAL        6.8                                      6.2-8.3 g/dl
      ALBLUMIN              4.5                                      3.6-5.1 g/dl
      GLOBULIN              2.3                                      2.1-3.7 g/dl
      ALUUMIN/ GLUBULIN     2.0                                      1.0-2.1
      BILIRUBIN, TOTAL      0.7                                      0.2-1.2 mg/dl
      ALKALINE PHOSPHATE    43                                       40-115 U/L
      AST                   16                                       10-35 U/L
      ALT                   15                                       9-60
   TSH,  3RD GENERATION     1.7                                      0.40-4.5 mIU/L
   T4 (THROXINE) , TOTAL    7.8                                      4.5-12.5 mcg/dl
      FREE T4 INDEX (T7)    3.0                                      1.4-3.8
   T4 FREE                  1.3                                    .08-1.8
   T3, TOTAL                83                                      76-181
   T3 UPTAKE                                  39H                   22-35%
 DIHYDROTESTTOSTERONE       53                                      ng/dL
                                  referance range 25-75
      IGF-I                 157
                                 REFERANCE RANGE 86-220
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Test Name In Range Out Of Range Reference Range:
TESTOSTERONE, FREE AND 250-1100
TOTAL, LC/MS/MS
TESTOSTERONE, TOTAL 779 ng/dL

Total Testo was measured by LCMSMS. The LCMSMS method
correlates well with our extraction/RIA method.sterone
% FREE TESTOSTERONE 1.19 L \

                              Reference Range:
                                  1.5-2.2

TESTOSTERONE, FREE 92.9 pg/ml
Reference Range:
35.0-155.0

C8C (H/H, RBe, INDICES,
WBC, PLT)
WHITE BLOOD CELL COUNT 4.1 3.8-10.8
RED BLOOD CELL COUNT 4.35 4.2-5.8
HEMOGLOBIN 14.3 13.2-17.1
HEMATOCRIT 41.5 38.5 -50.0
MCV 95.5 80-100
MCH 32.9 27-33
MCHC 34.5 32-36g/dl
RDW 12.6 11-15

PLATELET COUNT 179 140-400
CORTISOL, TOTAL 21
Reference Range: For 8 a.m. (7-9 a.m.) Specimen: 4.0-22.0
Reference Range: For 4 p.m. (3-5 p.m.) Specimen: 3.0-17.0

DHEA SULFATE 170 25-240
LH 5.6 1.5-9.3
PROGESTERONE 0.7 <1.4
PROLACTIN 2.7 2.0-18
ESTRADIOL 35 13-54
PSA, TOTAL 1.4 < or = 4

This test was performed using the Siemens
chemiluminescent method. Values obtained from
different assay methods cannot be used
interchangeably. PSA levels, regardless of
value, should not be interpreted as absolute
evidence of the presence or absence of disease.
SEX HORMONE BINDING
GLOBULIN 50 H 18-47 nmol/L

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The only clear issue is elevated E2 and SHBG. Lowering E2 should reduce SHBG over time and FT should increase.

Are you eating much red meat and green veges? RBC seems a bit low and perhaps hematocrit. Improving FT could move these closer to the center.

Lipid panel is excellent. Using a statin drug?