The label on the leucine bottle says not to exceed 20grams per day. Does anyone have any more information on the potential problems of taking larger dose of leucine?
Nothing to worry about.
Excess leucine would probably just be converted to glucose (some amino acids do this). The only possible thing that I could find online is excess levels of ammonia in the body (which is a hell of a lot more likely with excess protein consumption, and you know how frequent that is /sarcasm) and that leucine also interferes with de novo conversion of tryptophan to niacin.
So if you ingest 50g leucine per day and have no dietary source of niacin, then it may be a problem. 
[quote]silverhydra wrote:
Nothing to worry about.
Excess leucine would probably just be converted to glucose (some amino acids do this). The only possible thing that I could find online is excess levels of ammonia in the body (which is a hell of a lot more likely with excess protein consumption, and you know how frequent that is /sarcasm) and that leucine also interferes with de novo conversion of tryptophan to niacin.
So if you ingest 50g leucine per day and have no dietary source of niacin, then it may be a problem. :)[/quote]
actually leucine is one of the only amino acids that arent used in gluconeogenesis (lysine being the other one)
My bad, thanks for the correction. (Edit: Seems I was thinking of ketogenic AAs, and not glucogenic)
Also found ‘Maple syrup urine disease’, which is pretty much BCAA toxicity, but seems to be genetic.
And it also wins the award for ‘worst name for a disease’.
haha yeah imagine explaining that one
“so what the doctor say”
“its maple syrup urine disease…”
but yeah, its genetic and usually starts pretty early after birth
At some point of leucine intake, which would probably be extreme, taurine transport might become overly limited as they use the same transporter.
It is not that 21 g represents such a point, but a line has to be drawn somewhere and should be drawn with conservatism.
More to the point really though is that total dosing higher than this is we think unlikely to give better results.
Maple syrup urine disease also has a very low life expectancy rate.