Letro is difficult to dose - and i dont necessarily mean physically.
It is unpredictable in that in some it causes near total suppression of aromatase in doses of <100mcg. In others it takes more.
I use it so i can tell you what works for me but in all honesty it does not mean it will be a correct dosing practice for you. Trial and error will have to be your guide, and i hope you are adept at recognising the symptoms of both high estrogen and low estrogen in order to evaluate your dosing correctly… 
I find that on a moderate-heavy cycle (for me means 500-1000mg/wk aromatisable AAS) that 0.15mg to 0.25mg EOD seems to do the job. I would take more probably but i find if i dose above 0.2mg ED i have a severe reduction in sex drive.
I use a liquid product and i seriously could not deal with a pill form in the doses i need to use it. I believe BR (Bill Roberts) uses Letro regularly in a pill form - maybe you could ask him about the logistics of that.
BTW… it takes weeks to attain a stable blood level - which IME is noticeable once achieved - but before that i would say dosing would be best daily in order to achieve the stable levels as soon as possible.
It does have a long half life but not long enough for E5D whilst using (relatively large doses of) aromatisable AAS IMO.
Brook