More Science-Based “Low Normal” Testosterone Facts
“Low normal” total testosterone concentrations are associated with reductions in motivation, initiative, self-confidence, concentration and memory, sleep quality, muscle bulk and strength, diminished physical or work performance, feeling sad or blue, depressed mood, mild anemia, and increased body fat and body mass index.
Low normal serum testosterone concentrations are associated with reduced male sexual desire, function, performance and potency.
Low normal serum testosterone concentrations increase the risk for premature death from any cause.
Low normal serum testosterone concentrations increase the risk for death from cardiovascular disease, and increase the combined risk for suffering a first stroke or first transient ischemic attack.
Low normal serum testosterone concentrations increase the risk for both memory loss31 and developing clinical depression.
Low normal serum testosterone concentrations increase the risk of developing an increased level of systemic inflammation.
Defining “Healthy” Testosterone
Multiple peer-reviewed papers state that “testosterone deficiencies” are more prevalent and “desirable testosterone” levels in men are actually much higher than what is currently being considered as “normal” in doctors’ practices across the country. Case in point: A cross-sectional study of Swedish men ages 69 to 80 years showed the risk for premature death from any cause and the risk for suffering a major cardiovascular event were inversely correlated with the total serum testosterone concentration (i.e., the higher the testosterone levels, the lower the risk of death).
Specifically with regards to cardiovascular events, men in the highest quartile of testosterone (at or higher than 550 ng/dL) had a lower risk of cardiovascular events compared with men with lower testosterone.
More importantly, details from this study show that it did not matter if a man’s total testosterone was very low (below 340 ng/dL ) or moderately low (up to 549 ng/dL ) – all men with T levels below 549 ng/dL had a similar increased risk for suffering a cardiovascular event. Only when total testosterone exceeded 550 ng/dL did cardiovascular risk drop.
This is truly alarming, as cardiovascular disease is the No. 1 killer of men in the United States and even more – this study was published in the Journal of the American College of Cardiology.
These researchers documented a 30 percent reduction in cardiovascular events as well as a decrease in cerebrovascular disease incidence.
Men with the highest total testosterone had a 24 percent reduced risk of transient ischemic attack or full-blown stroke. Clearly, based on this study, the only target for “healthy testosterone” is to maintain total testosterone at or above 550 ng/dL.
As a health care practitioner, please note the following:
According to LabCorp, the “healthy reference range” for total testosterone is 348–1,197 ng/dL.
So, the lower part of this range completely ignores recent science that shows total testosterone levels need to be maintained above 550 ng/dL.
Subjectively, this broad range is ridiculous. As any 45-year-old man who has suffered with low normal testosterone knows, there is a world of difference in how a man feels and performs (both mentally and physically) when testosterone is “low normal” versus higher up the healthy “normal” reference range.