Asking for labs check. 37yo male, 207lb; dad, husband, etc. Lifting for 10+ years; I lift four days a week and run, ride my bike or murph in Z2 two days a week. Currently bulking at ~600 kcal surplus per day; not on creatine at the time. I was struggling with knee lesions for ~12 months when an ortho tested my test (along with a lot of other labs); tested was 267 ng/dl in August. Dr suggested start 200 mg/week of test cyp. I didn’t know I had low T symptoms (mainly low late day energy) until going on TRT took care of them; it’s made a big difference. After 8 weeks I was at 800 ng/dl Dr. upped me to 225 mg/week to try and push estrogen up for cartilage healing. I’ve been on it ~14 weeks with daily injections. Its honestly so hard to see the fine numbers on the syringe that I’m pretty sure I was over injecting. I ordered labs myself last week (LabCorp) and now my test and estradiol are concerningly high. I’m switching to every other day injections so I can tell what I’m injecting better and reducing back to 200 mg a week. I wanted legit srs thoughts on the following.
Currently concerns:
-how do I reduce estrogen?
-TRT increased by blood pressure by 10 mmHG systoliclly
-high ALT/AST
CMP
Glucose 98
BUN 17
Creatinine 1.11
eGFR 88
BUN/Creatinine Ratio 15
Sodium 137
Potassium 4.8
Chloride 100
CO2 25
Calcium 9.9
Protein 6.6
Albumin 4.7
Globulin 1.9
A/G Ratio 2.5 HIGH (1.2-2.2)
Bilirubin .6
Alkaline Phosphatase 76
AST 56 HIGH (0-40)
ALT 51 HIGH (0-44)
Thyroid
TSH 1.57 (.45-4.5)
Thyroxine 5.3 (4.5-12)
T3 Update 25 (24-39)
Free Thyroxine Index 1.3 (1.2-4.9)
Test
Total >1500 ng/dl HIGH (264-915)
Free 26.8 pg/ml HIGH (8.7-25.1)
The ranges for estrogen are not for men on TRT. Men on TRT with estrogen over 42.5 report less problems with erections and higher libido. If you’re going to run very high testosterone, you need appropriate levels of estrogen to function normally.
You’re taking more than the amount of Testosterone you likely need hence above range T levels and E2 levels. Lower your dose to lower your E2 otherwise if you feel fine don’t do anything.
Optimal E2 is different for everybody. Sometimes tenderness and puffiness happens around the nips with new hormonal swings. Often times it subsides on its own. If the lumps are more firm it would be time to take it serious and lower E2 or take a SERM.
I am in no way medical / doctor but I would think an aromatase inhibitor like anastrozole would be beneficial and I would start asap. Get your Dr to prescribe it or another equivalent solution as gyno isn’t something you want to mess with
I would agree with @swoops39. I’m not giving medical advice but would simply go back to your doc with your concerns. Thats enough AI to quickly flip flop your condition from high to low E2. If it were me, I would baby step the AI and add a SERM to block the gyno as I mentioned.
Ive just been put on anastrozole and its a 1/4 of a tab once a week. Maybe start there also. My estrogen is quite high so hopefully this dose brings it down to desired levels. Not crash it