As some of you know I have been on TRT for over 2 years and recently have had a hard time getting dialed in. I crashed my E2 a few months ago at 180 mg test cyp, twice a week with 0.5 mg of Anazastrol once a week. My test was at 330-ish and my E2 was <5 (Roche).
Since then I upped my test back to 200mg split twice a week and quit the AI altogether. And I have felt like absolute crap. Never felt worse in my life. Fatigue. Headaches. You name it. Well here are the results. Test is through the roof at 966 and E2 is at 65.8 (roche).
Keep in mind I ordered bloodwork including detailed thyroid labs as well as e2 sensitive so I will post those in a couple days when they become available.
It’s just crazy how much me levels fluctuate and I’m not quite sure what to do. Barely adjust my test and I dropped over 500. Took small dose of AI and crashed E2. Now I’m not on an AI and my E2 is through the roof.
Ugh. Any feedback is appreciated. Thanks everyone. I almost want to go back to 200mg test cyp split twice a week and 0.5 mg of AI once a week. I felt fine like that. Was dumb to try and lower test dose on my own. Can tell I’m holding water weight now. My test just doesn’t need to be that high I feel like. But I tried to alter it and it went down to levels that were low as when I was never on TRT.
Test Name Result Flag Reference Range Lab
CBC With Differential/Platelet
WBC 4.6 NORMAL 3.4-10.8 x10E3/uL 01
RBC 5.66 NORMAL 4.14-5.80 x10E6/uL 01
Hemoglobin 15.4 NORMAL 13.0-17.7 g/dL 01
Hematocrit 46.9 NORMAL 37.5-51.0 % 01
MCV 83 NORMAL 79-97 fL 01
MCH 27.2 NORMAL 26.6-33.0 pg 01
MCHC 32.8 NORMAL 31.5-35.7 g/dL 01
RDW 14.1 NORMAL 12.3-15.4 % 01
Platelets 331 NORMAL 150-379 x10E3/uL 01
Neutrophils 57 NORMAL Not Estab. % 01
Lymphs 35 NORMAL Not Estab. % 01
Monocytes 7 NORMAL Not Estab. % 01
Eos 1 NORMAL Not Estab. % 01
Basos 0 NORMAL Not Estab. % 01
Neutrophils (Absolute) 2.6 NORMAL 1.4-7.0 x10E3/uL 01
Lymphs (Absolute) 1.6 NORMAL 0.7-3.1 x10E3/uL 01
Monocytes(Absolute) 0.3 NORMAL 0.1-0.9 x10E3/uL 01
Eos (Absolute) 0.1 NORMAL 0.0-0.4 x10E3/uL 01
Baso (Absolute) 0.0 NORMAL 0.0-0.2 x10E3/uL 01
Immature Granulocytes 0 NORMAL Not Estab. % 01
Immature Grans (Abs) 0.0 NORMAL 0.0-0.1 x10E3/uL 01
Comp. Metabolic Panel (14)
Glucose 89 NORMAL 65-99 mg/dL 01
BUN 13 NORMAL 6-20 mg/dL 01
Creatinine 1.00 NORMAL 0.76-1.27 mg/dL 01
eGFR If NonAfricn Am 100 NORMAL >59 mL/min/1.73 01
eGFR If Africn Am 115 NORMAL >59 mL/min/1.73 01
BUN/Creatinine Ratio 13 NORMAL 9-20 01
Sodium 138 NORMAL 134-144 mmol/L 01
Potassium 4.5 NORMAL 3.5-5.2 mmol/L 01
Chloride 100 NORMAL 96-106 mmol/L 01
Carbon Dioxide, Total 23 NORMAL 20-29 mmol/L 01
Calcium 9.4 NORMAL 8.7-10.2 mg/dL 01
Protein, Total 7.0 NORMAL 6.0-8.5 g/dL 01
Albumin 4.5 NORMAL 3.5-5.5 g/dL 01
Globulin, Total 2.5 NORMAL 1.5-4.5 g/dL 01
A/G Ratio 1.8 NORMAL 1.2-2.2 01
Bilirubin, Total 0.4 NORMAL 0.0-1.2 mg/dL 01
Alkaline Phosphatase 47 NORMAL 39-117 IU/L 01
AST (SGOT) 28 NORMAL 0-40 IU/L 01
ALT (SGPT) 43 NORMAL 0-44 IU/L 01
Testosterone, Free+Total LC/MS Testosterone, Total, LC/MS 966.3 HIGH 264.0-916.0 ng/dL 02
This LabCorp LC/MS-MS method is currently certified by the CDC
Hormone Standardization Program (HoSt). Adult male reference
interval is based on a population of healthy nonobese males
(BMI <30) between 19 and 39 years old. Travison, et.al. JCEM
2017,102;1161-1173. PMID: 28324103.
This test was developed and its performance characteristics
determined by LabCorp. It has not been cleared or approved
by the Food and Drug Administration.
1 of 2 Free Testosterone(Direct) 30.3 HIGH 8.7-25.1 pg/mL 02
TSH
TSH 2.640 NORMAL 0.450-4.500 uIU/mL 01
Luteinizing Hormone(LH), S
LH <0.2 LOW 1.7-8.6 mIU/mL 01
FSH, Serum
FSH <0.2 LOW 1.5-12.4 mIU/mL 01 Estradiol Estradiol 65.8 HIGH 7.6-42.6 pg/mL 01 Roche ECLIA methodology
Thyroxine (T4)
Thyroxine (T4) 5.5 NORMAL 4.5-12.0 ug/dL 01
Triiodothyronine (T3)
Triiodothyronine (T3) 113 NORMAL 71-180 ng/dL 01
Triiodothyronine (T3), Free
Triiodothyronine (T3), Free 3.3 NORMAL 2.0-4.4 pg/mL 01
Sex Horm Binding Glob, Serum
Sex Horm Binding Glob, Serum 12.7 LOW 16.5-55.9 nmol/L 01
Your protocol is a better fit for someone with midrange SHBG, not super low SHBG.
Low SHBG men do better on more frequent smaller doses since we low SHBG men have a ton of free hormones. You should be injecting smaller doses EOD or ED and E2 will come down and be more stable instead of the large swings you must be experiencing.
You are also an AI over-responder like myself, half of a .125 AI is enough to knock estrogen low. Dissolve AI in vodka and dose using graduated pipettes, I dissolve 0.050 mg anastrozole in 5mls of vodka and dose .2mls.
I have read about the EOD injections and I’m fine with doing that. Should I take a tiny dose of the AI to knock the E2 down immediately, or just start spacing out my test shots and see if it lowers by itself?
And again I really don’t feel like my test has to be in the upper 900’s. My libido has never had any problems whatsoever or any area of sex at all. Has always been good. But I would rather see if I can get in the 600-700 range instead of being so dang high. I’ve been in the 300’s and my sex stuff was all good.
I’m on 20mg EOD and my Total T is 496 ng/dL, Free T 20.8 which is at the top of the range. You should be targeting Free T do to the fact that low SHBG men have quite a bit more than men with middle and high SHBG, these men need higher Total T to achieve the equivalent Free T of low SHBG men.
The estrogen will lower on its own without a doubt, it may take about a week for you to notice.
It’s basically an educated guess, I don’t know if you are a hyper excreter as well as low SHBG, but I would recommend something similar to my own protocol. Probably even an every day protocol which I like to recommend when SHBG gets below 15.
Your current protocol would send my levels much higher (1500+) do to my SHBG being a little higher.
20-25mg EOD or 10-14mg ED with the latter giving you lower more controlled estrogen which is your primary goal. It would be best if you could get by without the AI and an everyday protocol is your best chance.
Injections everyday requires commitment, use 29 gauge insulin syringes in the shoulders and outer quads and rotate sites.
Also my brain hurts from all this stuff. Need some basic math help. If 5 ML is 100 mg of test per injection, how many ML’s is going to get me at 25 mg per injection? Humor me! I like the sound of 25 mg every other day. Edit: 1.25 ML every other day if my brain is working.
Something is not adding up here. I will guess this first blood test with the 330 is full of lab errors.
Yes labs screw up all the time. With your low SHGB(if we can trust that is not a lab error) your TT and FT should be thru the roof on 180mg/wk of T cyp.
Totally agreed. It was mainly my fault though. I tested at a trough and missed a dose. These recent tests are 1 day after injecting 100mg and being off AI for 2 weeks.
Really appreciate the feedback. I just need to determine what T dosage I should go with every other day. 25mg EOD would still be significantly less T per week than I’m currently on (200 mg). But as we know that’s too much for me anyway. If I cut T dose in half, maybe my free T will cut in half from 30 to 15, which would be optimal.
I also completely left out my HCG. Have been using twice a week for the entire 2 years to keep the jewels working. 300 IU twice I week on the days I inject. Is it cool if I keep the HCG twice a week?
These were my levels back in the day (year and a half ago) when I was doing 0.4 ML twice per week. I need to get back to these numbers and never should have changed!
So that was at 180 mg. If I do 40 mg EOD that will get me to 160 MG per week. Which sounds decent and similar to the numbers that got me to the good balance above (that my doctor never should have changed me off of)
Thank you for helping this simple math illiterate dummy with the breakdown. If you tell me what those equate to in ML to go in the syringe per dose i’ll send you Tiff’s Treats for your bday.