[quote]Schmazz wrote:
Let me see if I can give this one more try… Here’s my theory:
You said that you used Letro during your PCT. My best guess is that you’re experiencing an estrogen rebound from the letro. GHRP-6’s prolactin release abilities is believed to be mediated by Estrogen (E2) in the study: “these GHRP-6 actions may be modulated by E2 at both hypothalamic and pituitary sites.”
My best guess is that because the prolactin is mediated by E2, and you’re probably on a letro rebound, I’d say you were in the wrong place, at the wrong time, injecting the wrong stuff. You’re E2 levels got high because of the rebound, and this mediated the prolactin release from the GHRP-6.
Now call me crazy - but here’s my idea. Try the Bromo you have, but you may also want to try running an AI with it. If the release of prolactin is TRULY mediated by E2, then an AI would cut back the E2 levels, and thus relieving the mediation of prolactin release by the GHRP-6.
Schmazz–remarkable thinking there! Even if the article cited is about mice (and humans–at least some humans–are not murines), this may underscore how E or T or DHT act at more than one site and are permissive of excretion of other hormones. (I am not sure “AI rebound” occurs, but that is not important to your idea.)
But I am going to play The Old Fart here, and suggest to the OP and that maybe it is time to stop everything and reassess: or does he want to look not like the Lactating Venus?
In one article I read that following a 100mcg dose of GHRP-6 the body will react with a 10x increase in GH secretion. How does this compare to the levels provided by a moderate GH cycle, lets say 10iu/day? If someone were to inject 100mcg, 3x a day of GHRP-6 in an attempt to keep GH levels high would the gains be similar to a GH cycle. I am not sure how much higher ones GH levels are after injecting 10iu or how long their levels stay elevated. The low cost of GHRP-6 compared to the high cost of GH made me think of this. But then the results may be very different.
[quote]2thepain wrote:
How is the gyno situation coming Sota? Did the bromo work?[/quote]
Bromo pulled through, redness and lactation subsided 100% back to normal now.I am finished with my cycle now, overall i was happy with what gains i achieved from it,although dunno if i would do it again but for the price it was well worth it.I think i will stick with aas and igf/mgf for now,no more experimental drugs for me.
Now i have to finally make my decision for my next cycle, i was either going to stick with the regular heavy test base/slow ester cycle or try out smaller faster ester cycle which i am completely new to, i was interested in those 3weekers that a few people were doing in here.
Now that you are off the GHRP-6 how well have your gains been retained? Have you noticed any fall off since stopping your use? Are your overall thoughts still rather high of GHRP-6 and its use during off cycle times?
I know it is probably still to soon to tell but was just wondering if you have noticed anything yet.
[quote]2thepain wrote:
Now that you are off the GHRP-6 how well have your gains been retained? Have you noticed any fall off since stopping your use? Are your overall thoughts still rather high of GHRP-6 and its use during off cycle times?
I know it is probably still to soon to tell but was just wondering if you have noticed anything yet.[/quote]
Overall im still standing high with ghrp. I lost a few pounds of water the last week, which actually made me feel/look a lot better. Thru the taper strength was slightly progressive,although nothing very impressive.pumps also stuck around for a while, even now being on NOTHING i still get a pretty impressive workout pump here and there.
My order of sachets was seized so now my next aas cycle has been delayed even longer,BS.
In a past post Sota mentioned that he didn’t shoot GHRP-6 in the morning because it made him lethargic for most of the day. I have been on for about a week now (shooting PWO and pre bed) and notice that I am having a hard time getting up in the morning. I am not a morning person anyway but I feel sleepy even if I get 8 hours of sleep. On my days off I will get 10 hours of sleep and still feel out of it. I guess this is one of the sides but since I am in PCT I think the more sleep I get the better my body will recover, I hope.
[quote]2thepain wrote:
In one article I read that following a 100mcg dose of GHRP-6 the body will react with a 10x increase in GH secretion. How does this compare to the levels provided by a moderate GH cycle, lets say 10iu/day? If someone were to inject 100mcg, 3x a day of GHRP-6 in an attempt to keep GH levels high would the gains be similar to a GH cycle. I am not sure how much higher ones GH levels are after injecting 10iu or how long their levels stay elevated. The low cost of GHRP-6 compared to the high cost of GH made me think of this. But then the results may be very different.[/quote]
Even at 300mcgm shot PWO (usually around 8:00pm for me) and no second shot, I was pretty damn lethargic at times while on GHRP-6. I never felt rested in the morning, and was pretty much dragging ass when I wasn’t in the gym for the last two weeks while on. I also had a lot of trouble falling asleep during those weeks, and felt like the slightest noise woke me up.
I finished tapering off a couple days ago and all of those sides have passed. I was also on about 800mg test during the four weeks I ran the GHRP-6, so at the time I didn’t know which sides to attribute to what, but now it seems like the GHRP-6 was the culprit.
That being said, the re-compositioning effects I experienced were well worth the sides.
Now that you mention it I have been having trouble falling asleep. Normally I can just lay down and be out in minutes. A couple nights ago it took me an hour to pass out. It is the mornings that I can’t seem to get enough sleep.
[quote]Dr.PowerClean wrote:
bushidobadboy wrote:
I have tried to find the evidence that GHRP-6 inhibits somatostatin, and to be truthful, I can’t.
Shame.
Anyway there are a couple of articles on pubmed that suggest an antagonistic reaction between the two peptides, but there also appears to be evidence that somatostatin can actually displace GHRP-6 from receptor sites.
In a lot of the literature, GHRP-6 seems to be freely interchangeable (in terms of equivalency of action) with ghrelin, which is a gastric peptide associated with hunger and gut motility.
Some studies show that a high (400mcg/kg bodyweight) dose of GHRP6 during/post MI, allow for up to a 78% reduction in infarct size. Great.
So, I’ve been looking into what compounds might inhibit trhe release of somatostatin, and GABA seems to be about the only freely available product.
Anyone got any ideas?
Bushy
Interesting that as a shrink, looking for compounds that work on the GABA site (other than benzos) was like looking for the holy grail. Really, there have only been two Gabatril and Neurontin. Gabatril was supposed to be the superior one, more receptore specific, but Neurontin in clinical doses ended up better (I know, it helped my radiculopathy pain prior to diskectomy.
Anyway, I googled Neurontin, unlcear if it will inhibit Somatostatin but it might, and its a pretty harmless compound. Doc
[/quote]
Alcohol and i believe Barbs act on the GABA pathway… useless here obviously!
back to normal now.I am finished with my cycle now, overall i was happy with what gains i achieved from it,although dunno if i would do it again but for the price it was well worth it.I think i will stick with aas and igf/mgf for now,no more experimental drugs for me.