Interesting Lab Results On E3.5D From 1 per Week

Pharma TRT
1

I went from 160 mg cyp once per week to 80 mg E3.5D 12 weeks ago. 12 weeks ago some of my labs were (on day 7):

SHBG 32, labcorp range 16.5 -55.9
TT 750, labcorp range 264-916
FT 14.5, labcorp range 6.8-21.5
Estradiol 52, labcorp range 7.6-42.6

My latest lab results with 80mg E3.5D (on day 3)
SHBG 27, labcorp range 16.5 -55.9
TT 1273, labcorp range 264-916
FT 31.5, labcorp range 6.8-21.5
Estradiol 49, labcorp range 7.6-42.6

Obviously the testing on Day 3 vs Day 7 will make a difference, but I was very surprised by the drastic changes. My doctor is concerned and wants me to test again in 6 weeks to determine if it was a poor result. She also said if they remain high (above 25 she’ll remain concerned and change my protocol). I said well, I’m feeling great, which I am, and my numbers we were concerned about before (Estradiol and Hematocrit are both decreasing) – why the concern with numbers and ranges? To which she replied, "because those are supraphysiological numbers and there’s a point of diminishing returns. I admit that these numbers are a little high, but I’d really like to remain at a Free Test around 30 and she made it clear that is not an option.

I could continue with what I’ve been doing and make sure that I leave more than 3 days between my last shot and my lab test; or I could go elsewhere. I’m kind of stuck where I’m at as far as lack of options here though.

2

I’d skip a shot and take the test just before the next one is due to get the numbers down and see where you end up

Worst case you have to find a new, possibly private, doc.

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3

On the same protocol 160 mg E3D 80 mg, but your number are a lot better!

UltaWellness/Quest Diagnostic
TT: 953 ng/dl (250-1100)
FT: 200.1 pg/ml (35.0-155.0) 20 ng/dl
SHBG 27 nmol/l (10-50)

I’ll probably be facing the same issue with my PCP. Guess I’ll just skip a shot before running labs with him.

4

lol @ “poor result”. Your numbers are much better now.

5

Yes there is a point of diminishing returns, except you see those diminishing returns when moving from 600 to 700mg per week.

6

If all your biomarkers look good, then high levels is nothing to fear. Doctors are taught in range is normal, so by being above normal your doctor grows concerned for no other reason that what they were taught, “in range is normal”.

7

I think a fluke is what she said. But yeah, I was thinking it seems like an improvement to me, both in numbers and in terms of how I feel.

8

I would love to work with a physician who has that outlook. But unfortunately feel like I have to take what I can get.

9

I had issues even when I was at 1100 total T so yeah, def wouldn’t just go by the numbers. No clue where I’m at now though

10

I read many studies before I got on trt and from what I read, the formula from the scientists was about 8 x the weekly dose was the AVERAGE ng/dl result over the period. It’s a non-linear decay, so it really peaks, then comes down quickly, so people don’t notice when they’re testing troughs.

so, that lab seems very normal for your dose, to me. Maybe +100 ng/ high or so, but it’ll vary each time you test it.

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