Most of the side effects subsided with me and I’m now taking 1000mg XR at evening with very minimal side effects. I take also 1000mcg B12 with it.
Metformin has done miracles to my appetite. Now I can finally do intermittent fasting, eat only 2-3 times per day in the interval 12-20 and manage to do around 2000 calories per day so weight loss is actually happening now. I’m not hungry all the time and I have almost perfect control on my nutrition. Before metformin when I see something delicous like chocolate, cheese or anything with gluten I was loosing my mind.
Does this mean I have IR? On the blood test with glucose loading it was debatable and not very clear, I did it two times. For sure its not like a strongly clear IR.
Also will this nice side effect of metformin suppressing appetite disappear with time?
I know sub-optimal T can cause IR. Is there a reverse cause-effect connection? Could not find any literature about it.
Cheers
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I took metformin for a while and so did my wife and a few of my friends.
As I recall, there are a few links between hormones and IR. IR can impair thyroid function (or at least T3 conversion) directly and low Thyroid can also lower T production. I think IR also has a more direct role on T production, independent of the Thyroid effect but I don’t recall the mechanism.
Was your glucose tolerance test with multiple insulin tests or only glucose? It’s much better to test insulin too. Blood sugar can be somewhat stable but if it takes a lot of insulin to do the job, then yes, you’d be insulin resistant.
If you didn’t test insulin and metformin helps with sugar cravings, then I would guess Yes, you probably was somewhat IR. Idk if the test was inconclusive with insulin pulls.
| Insulin (hungry) |
S |
|
4.6 |
mU/L |
Оптимални ст.: < 10.0 |
ECLIA |
| Insulin (2) |
S |
|
14.7 |
mU/l |
|
ECLIA |
| Insulin (3) |
S |
|
6.9 |
mU/l |
|
ECLIA |
| Optimal values hungry: < 10.0 mU/L on 60’ - peak values at 120’ : < 50 mU/L |
|
|
|
|
|
|
| Glucose |
S |
|
5.6 |
mmol/l |
2.8 - 6.1 |
HK |
| Glucose (2 ) |
S |
|
3.93 |
mmol/l |
|
HK |
| Glucose (3 ) |
S |
|
2.96 |
mmol/l |
|
HK |
Only one doctor stated this is IR, because the glucose was crashed on the second and third hour
Do you plan on staying on metformin long term?
Does the Dr believe that metformin can “reset” your insulin and then you can get off the metformin?
IR is also determental to SHBG. This is what lowers SHBG quite considerably and why men end up with hormonal issues after they have become obese. Women too ofcourse.
If I have no problems with metformin I dont mind to stay all my life
But my SHBG isnt low at all in fact its quite high
I got off because I don’t need it. It also hurts my stomach pretty bad. I even tried the slow release, as that’s supposed to be a bit easier but no cigar.
Yep, if blood sugar crashed, then that alone would be enough for me to jump on an insulin sensitizer.
Shbg is usually low from high insulin. And can be high from low T production. You could have both (w/ net influence leading to high shbg), or only low T production.
Just making s comment about shbg not you.
So I did not understand - Does metforming working well to control appetite means I have IR?