Peder, you need to do more research. Yes local inflammations DO in fact cause systemic rises in inflammatory compounds. In fact, just the other day I was using this phenomenon to track the progress of a patient’s LOCAL infection. You are right that wholebody release of inflammatory cytokines can lead to sepsis/death by high output heart failure. But that is at an absolutely massive level.
To understand why inflammatory molecules might be elevated systemically at relatively low, but clinically significant levels, you need a decent understanding of biochem and immunology. The reason omega 3s work so well is because the body produces four classes of eicosanoids which exert various effects from omega 3 and omega 6 fats. The omega 6 fats lead to pro-inflammatory compounds and the omega 3 fats lead to anti-inflammatory compounds. The ‘healthy’ ratio is 1:1. The typical industrialized nation ratio is 8:1 omega 6 to omega 3 or more. It’s been shown that to be reasonably healthy, you need to achieve an intake ratio of 4:1, but won’t see most effects until 2:1. Unfortunately most omega 3 studies dont use those ratios. But when they do you see startling results. This has been backed up by cross-sectional studies as well, where contrary to expectation, poor asians have lower rates of chronic degenerative disease and cancer than rich asians. Which is because they actually have much closer to natural ratios of n6:n3 intake.
Cytokines on the other hand are produced by cells that exist throughout the body. They are produced throughout are endothelium (like the lining of blood vessels), as well as the macrophages that live there. Not to mention by the circulating immune cells that are everywhere in our blood. Cytokine production can be stimulated by high stress, infection, or pretty much anything that disturbs our homeostasis. There are a couple of different mechanisms by which this might happen, which you can read about in a basic immunology book if you’re interested. In addition, the immune system is held in balance by a number of different systems, one of which is the Th2 cell system. When T suppressor cells are inhibited, you can have elevated levels of circulating (i.e. whole body) inflammatory agents. But suffice it to say that there are very real differences in circulating cytokines between groups. For an example of how this can affect health, google the JUPITER trial, which used the anti-inflammatory properties of statins to show that even in people with normal cholesterol, you can improve heart health by treating those with high levels of circulating inflammatory compounds. There’s also a lot of research on this and diabetes, cancer, skin conditions, allergy/asthma, and mental health. There is even more interesting research on levels of inflammatory compounds in women when pregnant and how their children turn out: autism, asthma/allergy, schizophrenia, and even obesity.
Regarding the OP’s question, no there is nothing to be concerned about. These supplements, while excellent for maintaining health, are not powerful enough to completely shut off the good effects of inflammation. In fact, taking all these supplements probably only restores you to the level of health of our ancestors who had much better diets prior to the industrialization of food production. The resveratrol, omega-3, and curcumin stack would pretty much put you on the same diet as for instance a pre-westernization South or southeast asian. And I’m not sure you know about this or not, but when you control for the effects of modern medicine, south and southeast asians on traditional diets have the lowest rates of chronic illness and disability in the world.
As for COX-1, NSAIDs are a bit different than supplements. The problem with NSAIDs is that they reduce COX-1 function WITHIN MUSCLE. The other compounds will not do this as they won’t be taken into the muscle to any significant degree.
). I was only questioning that wrong nutrition and/or habits can lead to such a significant increase of inflammatory mediators that you would get a quantifiable global effect.