IGF-1 LR3 and GHRP-6 Run

Pharma
21

My mileage is lower i suspect. Hmm - the trouble with IGF and anecdotal evidence (what else is there really??) is that it is likely to provide benefits - in the long term, not immediate, so the immediate dosing protocols come up with very little.

The BEST run i have read about used just 40mcg over 4 weeks - and i have read account suggesting the best results seem to START at 80-100mcg… So i am thinking of a compromise of 60mcg. Incidentally, he uses daily - what do you do Bill? Daily or otherwise?

Did you think you got any results AFTER the IGF run the first time, did a cycle ran afterwards illicit more for you than it may have otherwise - i understand it is near impossible to know.
I mean have you begun to stagnate in gains - even with AAS, and if so did you gain in the time between the IGF runs?

This is the account that has the best results immediately (i am not particularly looking for immediate results, although they are always nice. I am looking for satellite cell differentiation so i can grow more in furute months. Everything i have read suggests this may well be the case.

I am also going to be buying some MGF in the near future, i think this has more effect than IGF for muscle - especially the non-Peg compound. I will inject 200mcg bi’laterally PWO in lagging muscle groups for a couple of months, i may do a year with one month on MGF/one month on IGF…

Anyone have any ideas about the dosing of these peptides i have suggested - i am leaning towards 60mcg of the IGF and 500mcg of the G6.

Also - does anyone have a link to Gerdy’s GHRP run, it doesnt show up on a search - i wonder if he deleted it?

22

thanks, that link to that journal was really insightful!

23

[quote] Brook wrote:
My mileage is lower i suspect. Hmm - the trouble with IGF and anecdotal evidence (what else is there really??) is that it is likely to provide benefits - in the long term, not immediate, so the immediate dosing protocols come up with very little.

The BEST run i have read about used just 40mcg over 4 weeks - and i have read account suggesting the best results seem to START at 80-100mcg… So i am thinking of a compromise of 60mcg. Incidentally, he uses daily - what do you do Bill? Daily or otherwise?[/quote]

B.i.d. for the IGF-1LR3.

Only a little over a week to go for the 2 mg divided over 28 days, which is 71 mcg/day.

On whether there was a result after the 100 mcg b.i.d. use – not in the first several months thereafter.

EDIT: No, it was once daily. The above is mistaken.

24

b.i.d - is that Bi-Lateral Injections Daily?

25

Sorry, it is lingo for twice per day.

26

Also - those who have used it so far here… what did you mix it with, and did you add BA on injecting? I ask simply because i am trying to find a ‘common ground’ between those who got decent results, and those who got below par results.

:wink:

27

The higher dose IGF-1LR3, I drew from the provided benzyl alcohol solution and diluted in the syringe with saline at time of injection.

The current lower dose, since the volume of draw would be so small – an alternate solution would be obtaining some 50 IU insulin needles – I diluted with bacteriostatic water. This exceeds the solubility of BA in water however. So prior to drawing I shake thoroughly till milky, insert needle and invert, shake some more, and draw. This probably results in slightly unequal dosing injection to injection as the mixture isn’t perfectly homogenous, but I am guessing the variation is less than if I were drawing so little of the BA solution into such a relatively large syringe. Next time I won’t do this though.

The GHRP-6, I used sterile saline, but the vials only had to last one week. Probably better to have used bacteriostatic.

In principle I don’t think these differences can make a difference, sole exception being whether bacteria can grow in it or not.

Not sure what you meant by adding BA on injecting: actually waiting till moment of injection and adding some BA into the syringe would accomplish nothing. BA does not kill bacteria, at least not at any concentration that would be tolerable for injection. It only stops them from multiplying.

28

Sorry, it was a typo i meant prepare the IGF with BA and add some BW in the barrel on use… for a larger volume to work with.

Thanks for your reply, the thing is there are a lot of varying accounts on IGF in particular.

I received mine today, and i think i now know the answer… I got 20 x 0.1mg IGF and 7 x 5mg GHRP. The powder in the GHRP vial is 50x the dose of the IGF – BUT the IGF is significantly larger in volume… i assume due to fillers.
The point is, if i were so inclined i could quite easily sell each of my 20 x 100mcg vials as 20 x 1000mcg vials. I think this has occurred to a vast extent, considering the vast price from some vendors and resulting in many very poor reports of results from IGF.

Anyway i made up some Bacteriostatic Water today - i may do a week or so of the peptides before adding the AAS…

we’ll see what my self-control is like (proven very poor in this regard i’m afraid).

29

Your IGF-1LR3 is only 0.1 mg per vial?

Mine says it is 1 mg per vial.

It would not at all be the case that 1 mg of one lyophilized powder could not be greater in volume than 5 mg of another. There would be no reason for fillers except fraud.

30

I trust this supplier implicitly - and yes, they are 0.1mg per vial. The cost was no different, even though technically production costs are significantly higher (18 extra vials).

As for fillers, i only mentioned it (as i wouldn’t have thought it likely as fillers have no need in anything other than caps and tabs) because i read somewhere that the chinese sourced IGF can have fillers in that require AA to fully dissolve, rather than just BA/BW.

I will be using BA regardless.

31

On thinking about it again, I was wrong saying I had used IGF-1LR3 at 100 mcg twice daily.

It was once daily, positively.

32


The Blue is the IGF, and the Green is the G-6… I have started, and they are good. The GHRP will be dosed around 250-500mcg/shot.
The IGF i have settled at 40mcg/day split bi-laterally into 2x20mcg shots.

The IGF will be used on training days only, which is 4-5x/wk. The GHRP will be used daily.

33

I am wondering (that is, because I do not know) whether it makes sense to use IGF-1 and GH-release-stimulating peptides on the same day, as high IGF-1 level is suppressive on GH production.

Additionally and mostly unrelated, it’s a known fact that high glucose intake suppresses GH in the short period thereafter, so quite possibly if one takes in a lot of carbs post-workout that may not be the best time to use a GH-release-stimulating peptide. Or ditto for pre-workout injection if taking in a lot of carbs then.

34

awesome to hear that the run is underway comrade, pls do keep a detailed log as i’ll be running mine right after yours and i’m hoping yours will drop me some insights :wink: all the best!

35

[quote]Bill Roberts wrote:
I am wondering (that is, because I do not know) whether it makes sense to use IGF-1 and GH-release-stimulating peptides on the same day, as high IGF-1 level is suppressive on GH production.

Additionally and mostly unrelated, it’s a known fact that high glucose intake suppresses GH in the short period thereafter, so quite possibly if one takes in a lot of carbs post-workout that may not be the best time to use a GH-release-stimulating peptide. Or ditto for pre-workout injection if taking in a lot of carbs then.[/quote]

This is somthing i have been thinking about too… however i was thinking about it in a different line of thought;

It is suggested that exo-insulin increases the GH response to GHRP (can’t remember where i read that - but sadly it wasn’t in depth) - so i am hoping that the increased food intake after my larger shots of GHRP will assist in this (500mcg doses - i take a 250mcg dose before bed where i do not eat). Also… it should be noted, i do not eat glucose… and while i am bulking and eating less wholegrains in favour for slightly more processed grains, i am also adding plenty of protein and fat - significantly reducing an insulin response.

Not only that, but i was hoping that the GH lowering effect of exo-IGF due to the negative feedback, will be reduced by the G-6 and the insulin like effects of the IGF will also assist in the GHRP effects on GH secretion. Of course, the opposite may be true… but all in all i am happy to risk that for the advancement of science :wink: lol!
I will run this as planned, and next time i will be running either MGF(non-peg) and IGFLR3 or GHRP and GHRH.

At the moment (this first two weeks is a bit of a trial dosing period) i am dosing 40mcg IGF immediately PWO, in one muscle group, in one to two heads. This will continue throughout the run.
I am dosing the GHRP in the AM around 1-2 hours before training, PWO around 1-2 hours after the IGF (which is used directly PWO) and before bed in a lower dose to assist sleep and GH release.
I am going to need to use around 1-1.5mg of GHRP for the best appetite stimulation… i only get appetite stimulation at or around 4-500mcg in a shot, and 250mcg is not noticeable (in that regard).
So i will be dosing 4-500mcg in the AM AND PWO and ~250mcg before bed. I believe this is a high dose for this compound, but it is cheap as fuck! :wink:

JJ

36

[quote]warriorathlete wrote:
awesome to hear that the run is underway comrade, pls do keep a detailed log as i’ll be running mine right after yours and i’m hoping yours will drop me some insights :wink: all the best![/quote]

OK… in that case:

GHRP-6

Injected daily Sub-cut in the stomach.
500mcg AM 1-2hrs before training.
500mcg PM 1-2hrs PWO.
250mcg PM before bed. No food following.

IGF-1 LR3

Injected PWO only (4-5x/wk) IM.
10mcg lower Pectoralis Major, 10mcg Pectoralis Major - Bi-lat. Total 40mcg.
20mcg Lattisumus Dorsi - Bi-lat. Total 40mcg.
10mcg Vastus Lateralis, 10mcg Vastus Medialis - Bi-lat. Total 40mcg.
10mcg Biceps Brachii; Long Head, 10mcg Biceps Brachii; Short Head - Bi-lat. Total 40mcg.

Minimum of 1 hour given between IGF and following GHRP shot.

Steroids

ATM i am using just 200mg of Test Enanthate a week… and will continue to do so for another 10 days - to finish my 3 week cruise.

Then i will be frontloading the following cycle:

Wk1-6 Test 1000mg/wk
Wk1-6 Tren 525mg/wk
Wk1-6 Dbol 350mg/wk

I will be dosing the injectables according to their ester length… but i will only be dosing the Dbol post workout and in the PM. The reason is because i dislike training on Dbol and have dose for some time, it reduces my energy - BUT i know that IGF is supported with this drug… likely due to the extra estrogen, so will be dosing around 15mg 3x/day ONLY after training, with the first dose directly PWO.
I will be supplementing ZMA in the evening, as zinc is beneficial to IGF levels also, as well as sleeping anabolic hormone levels and this is IME the best zinc compound available.

I am currently;

206lbs, 94kg (Fasted)
5’8"
12%

My numbers are educated guesses based on higher rep lifts:

Bench 315, 140kg. (to chest)
Squat 315, 140kg. (Below Parallel)
Deadlift 405, 180kg. (straps only)

Don’t expect too accurate number logs… as i simply don’t concentrate on max effort lifts.

Thats all for now i think.

B

37

[quote] Brook wrote:
Bill Roberts wrote:
I am wondering (that is, because I do not know) whether it makes sense to use IGF-1 and GH-release-stimulating peptides on the same day, as high IGF-1 level is suppressive on GH production.

Additionally and mostly unrelated, it’s a known fact that high glucose intake suppresses GH in the short period thereafter, so quite possibly if one takes in a lot of carbs post-workout that may not be the best time to use a GH-release-stimulating peptide. Or ditto for pre-workout injection if taking in a lot of carbs then.

This is somthing i have been thinking about too… however i was thinking about it in a different line of thought;

It is suggested that exo-insulin increases the GH response to GHRP (can’t remember where i read that - but sadly it wasn’t in depth) - so i am hoping that the increased food intake after my larger shots of GHRP will assist in this (500mcg doses - i take a 250mcg dose before bed where i do not eat). Also… it should be noted, i do not eat glucose… and while i am bulking and eating less wholegrains in favour for slightly more processed grains, i am also adding plenty of protein and fat - significantly reducing an insulin response.[/quote]

However whole grains are converted to glucose by the time of reaching the blood. The pituitary cannot know whether the glucose was eaten as glucose or as complex carbs.

On insulin increasing response, it may be that this is from lowering blood glucose levels. I wouldn’t be surprised that if you prevent your blood glucose levels from rising despite high carb intake due to the insulin use, that you would avoid any effect of glucose on GH release. Actually I’d think that probably would be the case, as you are thinking.

38

Very cool - thankyou.

So it is actually Glucose that is blunting to GH release, and NOT insulin (as i previously believed)?

39

I’ll look into it further this evening. The alternate idea you suggest, that it really could be insulin level that causes the effect seen after administration of glucose, certainly on the face of it could be the right one. Hopefully the data is out there in the literature to establish the point – I’d be surprised if not.

At the moment, your explanation seems better than mine so I won’t be surprised if the literature backs the insulin explanation. (Better because it’s exceedingly common for tissues to have responses to insulin, but not so common for them to measure, so to speak, blood glucose and respond to that.)

40

Previous post hasn’t appeared, so can’t add directly to that

But on the other hand if it is correct that exogenous insulin increases GH release, the fact that glucose administration (which yields insulin increase) decreases GH wouldn’t fit in with that.

So it’s an interesting question: I’m looking forward to seeing what there is on this. I really don’t know a whole lot on the peptides – never said I did, either! :slight_smile: