Due to androgen deficiency I had the same issue (re looking young), though ever since the age of 14 (or so) I was on the stockier side.
Very soon after initating TRT hair sprouted… Everywhere. Went from hardly growing patchy peach fuzz to being able to grow a beard. I did go through puberty, though the changes regarding the development of secondary sexual characteristics were very significant when I started TRT as opposed to puberty; which started young but progressed very, very, very slowly until development somewhat stagnated during my early teens and to my perception ultimately started regressing during my mid/late teens
I look considerably older than I actually am at this point and receive comments about it regularly. I’d argue it’s a combination of being relatively lean (facial aesthetics), the way I speak to people and facial/body hair exceeding what the majority of those my age sport.
If one wants to bring up a particular lift, is there an optimal frequency one should train said lift?
For my weight I have a fairly respectable deadlift (for my weight/by recreational lifter standards), a sub par bench, a respectable OHP and a poverty squat.
The latter is a result of me substituting leg press/hack squats for barbell squats. How can I bring up my back squat/front squat to be more aligned to that of my deadlift? My bench/squat 1RM’s are roughly the same… It’s that terrible…
Was wondering whether squatting say 3x/wk (and putting a lesser emphasis on other lifts for the next 3 months or so) might be able to (somewhat) even things out.
Yes. I built my squat by focusing on it and squatting every work out. Yes this was taxing but my CNS eventually learned not to freak out about the heavier weight.
Mn has a ton of trees and lakes. Much more than those states, but our mountains are only up north and really small in comparison (they do classify as mountains though, and a few have goodish skiing). There is more opportunity for mountain stuff in those states for sure, but we do also have cliffs. I’ve done climbs that require multi pitch due to being over 60 meters long. It surprises some people as they think the state is flat.
I have an uncle in Jackson wy, and it is a great spot. Very expensive though. I’ve camped in his yard before, and it’s nice enough for me.
Damn that lockdown sounds like the worst one I heard of. That was what I meant above with Aussie is even more restrictive than other westernized states.
I saw another one attributed to him where alcohol was the highest over heroin. Probably different set of variables. I would agree largely with the one you posted.
Didn’t mean to put you down. I think this type of rack is a good cheap choice.
Do you know actual figures and measured risk of psychosis from LSD use for example?
Risk of psychosis is far higher in both alcohol and cannabis, i know this from studying it for years, and know it from my partner who is a consultant psychiatrist that specialises in addiction.
The issue is that as you say while under the influence someone can be diagnosed as having psychosis, your statement that taking a trip dose reliably induces it is, im sorry a nonsense. Ive been doing so in the presence of a consultant psychiatrist for over a decade at no point was i certifiable.
Regardless, i wasnt actually pointing the finger at you and it’s not a discussion im going to get into further online.
The fact is the old propoganda about these drugs being highly dangerous remains when they a re a a magnitude less so than painkillers etc that are often handed out all too easily.
You didn’t discredit a word he wrote. It just seems you didn’t understand the nuance of his post. Under the influence of LSD someone has an acute psychosis, as one of the hallmarks of psychosis is hallucination. The 5-HT2A theory of psychosis is built on this observation (and on the one that second generation antipsychotics antagonize the receptor).
I agree that psychedelics are one of the least harmful drugs one can take. They have nearly no risk of dependency for example, while alcohol, cannabis and tobacco have that. The acute risk is also extremely low.
The discussion here was also not about psychedelics.
The studies I based my statements on cannabis on are studies from 2018 and 2019.
I’m well read in the new studies about LSD and I know the therapeutic value of it. Many come from a lab not far from where I live. I can back up my claims.
Use is self regulating. Tolerance builds up from the second one takes the first dose.
Whats more I’d tend to disagree with this scale. Crack cocaine is a hell of a lot more addictive than ethyl alcohol. We don’t have crack in Aus, but methamphetamine abuse is a HUGE problem. If crystal methamphetamine reached the proportion alcohol abuse has within our society we’d have an even bigger problem on our hands. Roughly 5-6% of Australian’s have used methamphetamine at some point, roughly 1% use on a monthly basis and 0.4% use on a weekly basis (all stats taken from different sources). The vast majority of Australians drink alcohol, with some 35-40% (ish) consuming weekly, though statistics for illicit drug use within youth demographics are skyrocketing as people are seeking out booze replacements. One recent source appears to state the average Australian gets drunk 31 days out of the year. Binge drinking is very common amongst college aged/high school students and middle aged adults, and significant psychosocial ramifications are associated with these patterns of alcohol consumption.
That being said, flip the statistics re methamphetamine usage to that of our current alcohol stats and we would have a far bigger problem on our hands. Methamphetamine and crack cocaine are unequivocally more harmful than booze. I’m on the fence about opiates/heroin; they have a penchant for inducing addiction/dependence well above that of alcohol. But provided a reliable, sustainable source is available to the addict I’m not sure if it results in the same antisocial behaviour in comparison to the societal detriment mediated from binge drinking. Physical harms mediated from opiate abuse can be fairly extensive. Osteoporosis, endocrine abnormalities (and secondary co-morbidities mediated from untreated hypogonadism), brain damage mediated from hypoxia during overdose, transmission of blood Bourne disease if sharing needles, immunosuppression and more.
and… buprenorphine being LESS harmful than ketamine, weed, E, Khat, LSD? Nope… no way…
True, however you require escalating dosages to produce the same effect. Within 2-3 days it’d become unfeasible to take such an arduous dose of X psychedelic following recurrent, daily use.
Imagine going out for a drink, the next day you do the same however you now require six drinks to get where one drink got you yesterday, the day after it’d take 36 drinks and so on. It’s simply not feasible
After which it takes weeks for tolerance to fall back to baseline. Aside from the fact psychedelics don’t have a penchant for producing addiction/dependence, it’d be quite difficult to become addicted to something of which you literally can’t continue to use regularly for it won’t produce the same desired effect.
There is a differention between opiate/benzo tolerance and tolerance to psychedelics. For opiates like heroin, tolerance begins to develop after a couple of days. For psychedelics this effect is literally immediate and extensive. Take 10mg oxycodone (or whatever opiate substitute) post surgery for pain relief, take the same dose the next day for the same purpose and a therapeutic effect will still be elicited, hell acute use of opiates (up to 12 weeks) at non-escalating dosages have been documented to be efficacious for pain relief. Take 100ug LSD for… whatever reason, do the same the next day and zilch… nothing…
You’d probably require well over 1000x the initial dose to elicit a similar effect to day 1 following continual use of psychedelics for weeks on end. That being said you are correct in that tolerance doesn’t correlate to the addictiveness of a specific compound. I don’t believe LSD/psilocybin/mescaline alter delta fos B expression amongst other things like opiates, nicotine etc do.
I should also note I don’t believe most heroin users end up using 100x the initial dose following a few weeks of use. I think you are referring to hypothetical scenarios/escalating dosages following daily use in effort to replicate the same elicited effect. In Australia for reference heroin is rather expensive. Many who are unfortunate enough to start using/get hooked tend to by and large use to ward of withdrawal symptoms
There’s a difference between heroin and oxycodone and it is not small. People generally don’t take heroin for pain relief (besides in America).
In humans, mental tolerance to LSD substantially manifests 24 h after its first administration and reaches a maximum by around the fourth day. Once established, tolerance cannot be overcome even if the initial dose is quadrupled. Mental tolerance to LSD generalizes to psilocybin and mescaline but not to tetrahydrocannabinol or amphetamine. As to LSD’s somatic effects, mental tolerance most reliably is accompanied by tolerance to mydriasis. Five days of abstinence is sufficient for tolerance to be reversed; symptoms of withdrawal are not encountered.
I think this sums it up pretty well and shows the clear differences to opiates.
I think you got my point wrong. You said, substances that build tolerance fast don’t get abused and I just gave an example. Yes, it’s not possible with LSD probably but nearly nobody does or would do it with LSD anyways, it’s just not even comparable.
Nope. That’s how overdose happens in heroin. People often overestimate how fast it builds. I maybe exaggerated a bit but for a good amount of people 100x is true.
In the UK/certain countries from my recollection diacetylmorphine can be/is used to treat pain within an acute environment following myocardial infarction/childbirth and/or for end stage cancer pain and post operative pain.
I thought diacetylmorphine was a schedule I controlled substance in America? In which case if people were to use it for pain relief it’d encompass recreational use or self medication.
Plenty of substances that build tolerance rapidly are abused (benzodiazepines come to mind, and as you’ve stated certain opiates). Rather I’ve yet to find literature covering any other psychoactive substance of which tolerance builds faster than that of classical psychedelics.
Overdose also occurs due to fentanyl contamination (or contamination re more potent analogues/substitutes) and/or people overestimating tolerance following prolonged breaks.
Really? I thought they were more/less the same thing/just as risky as one another; rather route of administration heavily dictates addictive potential. Could you link literature for me to read regarding this?
Yes that’s what I meant. People in America get addicted through overuse of opiates and then switch to heroin self medication apparently.
Yes it’s extreme.
Oxycodon as a substance is not much different if you meant that, then you are right. The exact receptor affinity is not the same but that doesn’t matter. Rather oxycodon in its prescription form oxycontin has a very different application form. Oxycontin is an oral slow release system which takes off the “kick” from the substance. For the classical opioid euphoria a rush into the CNS of substantial amounts is required. Oxycontin doesn’t rush into the CNS but slowly increases plasma levels and therefore CNS levels. Oxycontin therefore makes patients dependent but not addicted. The problem arises when dependent patients don’t get good help for coming off. Then they resort to recreational use.
In Australia we have both. Targin is OxyContin, this is slow release Oxycodone paired with naloxone in effort to deter abuse. That being said the rate of release relates to the coating they have on the pill that delays release. The pill can still be crushed and swallowed orally (in which case release is IR). As you know Nalaxone acts as a non selective opiate receptor antagonist, and is active instantaneously if the drug is injected or insufflated. Though to my knowledge from oral dosing naloxone only has an oral bioavailability of like 1%, the naloxone only becomes significantly active (to an extent required to reverse respiratory depression/percieved euphoria) if the pill is crushed and insufflated, smoked or injected.
Then we have endone, this is Oxycodone IR. I’ve taken both (for pain, not rec use). Both feel fairly similar to me, the duration of action regarding OxyContin is longer, and side effects like nausea, gastrointestinal irritation etc are less pronounced (presumably due to the effect naloxone has regarding opiate receptors within the gastrointestinal tract). I’ve always been extremely hesitant to take OxyContin/Oxycodone, even for post surgical use due to fear of addiction. I don’t appear to have an addictive personality, but I can’t help but keep thinking Oxycodone =/= heroin, and I’d never take heroin. Also know people who started with painkillers, progressed to heroin. It’s a scary thought to end up like them (dead and/or irrevocably screwing up my entire life).
Anecdotally Oxycodone is my least favourite pain med. Whenever I have surgery I’ve actually come to ask those in charge of post operative pain management “please don’t give me Oxycodone”. Tapentadol for the win… Less nausea, no itching, no constipation etc.
Both formulations (IR/ER) give me a relaxed, spacy (albeit nauseous/sick) feeling.
I don’t like opiates… They’re some of the most side effect ridden medications I’ve ever taken. I recall after one operation I didn’t shit for a week thanks for Oxycodone.
Back during the heydey of the opiate epidemic within the USA these medications were dished out like candy under the pretence they weren’t addictive. There’s a decent book on this called dreamland.
People also resort to rec use when they’re given a 180 day script of OxyContin for post operative pain management wherein use is only indicated/appropriate for say… Ten days. The individual kind of likes how “relaxed” the OxyContin makes them feel and subsequently the patient keeps taking them after pain subsides because “hey, the doctor clearly says it’s okay… Look at my script”, perhaps they start escalating the dose.
They run out, the doctor either gives them a refill OR they’re cutoff. If option A occurs they have a sustainable supply for a few months, then they’re cut off. Under both scenarios the patient now resorts to recreational use.
