[quote]Whisper9999 wrote:
Dandalex wrote:
My point is this: the Masai, turn-of-the-century Americans, the French, the Eskimos and other cultures have proven that there is a healthy lifestyle where you can have your saturated fat and cholesterol w/o having risk factors. There?s nothing really to argue about that, is there? They?ve laid the ground work for us ? all we have to do is figure out what they did.
But, more to the point, you keep making an assertion that, at least in my case, I basically agree with and then calling me a ?flat earther?. I agree that for the typical American, which is who comprises the great majority of studies, that cholesterol is a risk factor.
But that?s not what I?m getting at. Here?s what I?m trying to get everyone to think about:
–Is cholesterol a risk factor for TOTAL mortality? I don?t believe that this been solidly established at all.
–Does there exist a ?healthy? lifestyle that negates the risk factors of medium cholesterol? (The Masai, the French, tun-of-the-century Americans and the Eskimos all say a resounding ?yes? if you ask me.)
And please don?t tell me saturated fat and cholesterol are not important here on T-Nation. I have read the studies that show the ration of SFA/PUFA is directly related to baseline T-levels. Everyone on T-Nation, esp. those over the age of 35, should be very interested in the subject.
Imo, their T depends on it?
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Whisper, the objective is not to discuss wheter or not you can negate the risk factor with other things. Of course you can negate the influences through various means.
The topic here is on cholesterol as a risk/benefit factor.
For example, we know that elevated levels of cholesterol are associated with cardiovascular mortality. Is it associated with total mortality? I haven’t checked that out yet, but it is bound to be more difficult to prove by the simple definition of total mortality and the size-of-effect dilution that comes in.
As for the healthy lifestyle your are talking about, lets not compare apples and oranges. Yep the French have a good amount of fat in their diet, mostly of a relatively beneficial kind. But it kinda helps that they take in like a third less calories and have higher energy expenditure.
As for the Eskimos, by 50-55 years of age, around 25% of them have CHD even with there high consumption of n-3 FA. Now how do we know that it was not lower total calories and increased energy expenditure that might accout for positive factors.
As for the Masai, they have advanced atherosclerosis, but do not suffer the consequence. Lucky for them. That is like arguing that my grand-father is proof that cigarettes don’t kill people he smoked 2 packs a day since he was 13 and lived healthy until 97 when he died in a car crash…(My real Grand-dad died during a bypass op, shouldn’t have been smoking). So they have atherosclerosis, what we don’t understand is why they don’t die from it like the rest of the world. Are they then what you wish to base your assertions?
The point is, just because we don’t know exactly why X, Y, Z populational subgroups is not as affected as another does not imply in anyway that established links do not exist.
You can smoke and be a marathoner, and maintain a healthy lung capacity. How does that change the fact that smoking reduces lung capacity, for exemple.
You can negate something but you would probably be alot better if you didn’t do the negative thing in the first place. You can be overweight and active, and have almost the same risk profile of a normal weight and sedentary individual. Your risk profile would be much better if your were normal weight and active. You can drink 4 gallons of Pespi a day if you run 20 miles a day…
I am failling to see the point here. In most nutrional based instances of risk factors, the size of effect is often small. Cholesterol also has a moderate effect, but such effect is probably moderated (influenced by) other factors.
Some people are prone to atherosclerosis even with low level of serum cholesterol, but for these people, the higher the cholesterol, the worst the prognosis is.
On the other hand, some people don’t seem to develop significant atherosclerosis even in the presence of high level of cholesterol.
What does that imply? Nothing beyond that some people are genetically ‘‘superior’’. Hell, my sendentary best friend who eats mayonaise by the tablespoon to put on his full-fat mergez and french fries with the 2 liter of sugary fruit juice is an example of this.
There I was, a cocky confident bastard, training for a marathon, hitting the weights 4 times a week and eating cleaner than Berardi himself, so convinced that I would show him the errors of his ways when the blood tests came in, saying how bad his results would look.
Of course, he humiliated me on blood tests. He had lower glucose levels, lower glycated hemoglobin, lower triglycerides, above range HDL and below range LDL. My numbers were good compared to the average popopulation, but damn I was maxing out on all variables and he wasn’t doing squat…
Personal aparte aside, we have not yet figured out who will respond to cholesterol and who will not, just like we don’t know exactly why some poeple just never get lung cancer even after having smoked like coal plants for 70 year straight. What we do know is that a lot of people out there respond to high levels of cholesterol, which is one of the reasons why statins work well at reducing mortality/morbidity in this group of patient. We also know that statins as primary prevention are really not that good, but hey, not many things are.
How many of you guys know the size of your arteries, anyone had an echo or an angiogram lately?
End point, you don’t know if your are ‘‘immune to cholestorol/atherosclerosis’’, normal or prone. Most people belonging to the normal group, it would simply be wise to trie to maintain ‘‘normal’’ levels of cholesterol.
As for saturated fats and cholesterol and T, I understand these might be interesting research venues and are topics that are important to you, if I remember our previous exchange correctly, but this represents too large an undertaking at this late hour. Then again, this was not a point with which I had beef in my earlier rant.
For example, this belongs in an area of research that I might want to look into as it is more cutting edge and intellecutally challenging. As opposed to other proposed opinions.
For Zeb, I appreciate the comment on my post if it was not being sarcastic, but in the words of Conan the Barbarian, if your were, ‘‘Then to Hell with you!’’.
I hope that you realize what a huge undertaking it is to mount a rebuttal to an article like the one you have submitted, or to any of Dr Mercola’s article for that matter. The first because it requires inspecting all the cited studies for their infered conclusion in the text. The second because he simply twists the truth on so many issues that explaining them all becomes so tedious you want to stop.
As for Dr Ravnskov, its interesting, and expert on cholesterol but hasn’t published a single article on it execpt for comments againts the conclusion about statins/dietary fat and cholesterol.
Now I don’t like to refer to Experts but I am wondering why he’s the only guy who seems to think this way about cholesterol. Where is everybody else? The pharm companies haven’t bought the whole world, especially not all university/institution based researcher, who quite often, just don’t like them.
I hope this was not a too incoherent/typo ridden message for you too read, but I was a bit tired as I wrote this.
AlexH.